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Re: Rejuvant?
@JGC What is your rationale for taking AKG in the evening? FWIW I take it first thing in the morning , on an empty stomach. Reason being, better absorption.
- aribadabar
- 4 yrs ago
- General Discussion
- Reported - view
Re: Rejuvant?
@JGC I also have reports from people taking Kirkman's Ca-AKG product along with berberine who reported reduced methylation age as per their Trume results. So Jimmy2's results are not undisputed.
- aribadabar
- 4 yrs ago
- General Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Andrew Whitfield Fairly certain you have received Berberine then. Saturated yellow, VERY bitter powder - checks out.
- aribadabar
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Andrew Whitfield Don't know which one is Doctor's Best but the upper, slightly lighter, non-glowing under UV one, seems like the Fisetin I have come across.…
- aribadabar
- 4 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Fred Cloud You must be either extremely sensitive to it or weigh 150lb or less. Make a proper biodistribution calculation at fisetin's un-assisted bioavailability and see how unlikely it is to do…
- aribadabar
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Andrew Whitfield So crappy extraction i.e. high level of residual solvents it is. Your call but I would not consume it as it markedly deviates from a known good sample.
- aribadabar
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Mick IsSick You are wasting your time and money doing 100mg/d of something as poorly bioavailable as fisetin IMHO. 3 days of 2-3g/d would yield a more meaningful result.…
- aribadabar
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Andrew Whitfield As to why it is written as bitter in a chemical datasheet, perhaps in chemistry speak bitter means anything "not sweet" ?
- aribadabar
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Andrew Whitfield I only used this bulk source: https://www.ebay.com/itm/293083396786
- aribadabar
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Andrew Whitfield I have tried both Quercetin and Fisetin from 3 different sources - they ALL tasted very similarly and none were bitter at all. I also tried Berberine which was vile bitter yellow…
- aribadabar
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Andrew Whitfield You have a known good sample from Doctor's Best which you stated yourself is not bitter at all. If you still have any doubts about my statements,…
- aribadabar
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Andrew Whitfield If I have to guess, bitter yellow powder points to Berberine.
- aribadabar
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Andrew Whitfield Fisetin is NOT bitter. It is VERY similar yo taste and appearance to the more popular and more widely available Quercetin ( differing by only a single -OH group) - light yellow…
- aribadabar
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: GlyNAC
@Qimin You PAH= Pulmonary arterial hypertension.
- aribadabar
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: GlyNAC
@Allen Glycine is very pleasant but cysteine isn't. You need to overwhelm it with something sweet and dilute substantially.
- aribadabar
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: GlyNAC
@JGC I don't see the point of overpaying for a designer product if we are talking about simple amino acids. Just buying their Ajipure version is sufficient if one is concerned about quality.…
- aribadabar
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet?
@aribadabar Michael Lustgarten posted a good overview of the various epigenetic clocks: https://youtu.be/iNnvF1Eh7VE
- aribadabar
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet?
@Brin Chikovski I see what happened - you used a short-hand for the LEF's offering - it includes a pretty comprehensive metabolic panel of which CBC (Complete Blood Count) is only the last section…
- aribadabar
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet?
@aribadabar rough*
- aribadabar
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet?
@Brin Chikovski Besides CRP and CBC, you also need the following analytes for the Phenotypic age calculator: albumin, creatinine, glucose, alkaline phosphatase.…
- aribadabar
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Peter H. Howe It's a tradeoff. Frailty vs. inflammation/oncogenesis/oncoproliferation. One has to decide what's more important for them. For myself, frailty is of lower priority to the other issues.…
- aribadabar
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Peter H. Howe And I don't reject that point, I just go further into its nuanced understanding i.e. the mTOR activation needs to be pulsatile, not continuous,…
- aribadabar
- 4 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Peter H. Howe For overall health , it is best to have short mTOR bursts during muscle building exercises as opposed to constant strong mTOR signalling which is unquestionably deleterious.
- aribadabar
- 4 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Peter H. Howe They hypothesize that Omega-e FFAs increase mTOR and that's how they try to explain the anabolic effect. Looking at the papers they base that HYPOTHESIS on,…
- aribadabar
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Peter H. Howe Hey Peter, the opposite is true about the mTOR signal - it increases with age and thus needs to be suppressed more which is why senior people have been taking higher Rapamycin doses…
- aribadabar
- 4 yrs ago
- Senolytics Discussion
- Reported - view

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