Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet?
I've been reading the research on how low-dose lithium looks to be helpful in age mitigation as outlined in links below. I want to try it at the level of 5mg to 10mg a day. I want to use the medication Lithium Chloride that is used in the studies (not Lithium orate that is sold over the counter, but for which little data is available on).
Typically Lithium is used in medical applications for mood disorders, and the pills are typically in the range of 250mg to 450mg.
Can anyone recommend a good way of somehow getting a reliable 5mg to 10mg dose of Lithium from these larger dose pills. I could pulverize the pills and try to divide the powder to get 1/20th or 1/30th of the amount. That seems very difficult to do. Another way would be to dissolve the Lithium pill into some sort of liquid that could more easily be measured out volumetrically.
Can anyone suggest a good way to do this?
Lithium Microdosing:
Research on Lithium and Aging:
A triple drug combination targeting components of the nutrient-sensing network maximizes longevity
https://pubmed.ncbi.nlm.nih.gov/31570569/
Low-dose lithium uptake promotes longevity in humans and metazoans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151375/
Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis
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aribadabar said:
the correlation to biological age is about 65% , not 94%, as Michael posted, so it is a very tough estimateThanks - I Believe the LifeExtension tests cover those:
Where did you get the info that the correlation for biological age is 65%?
Yes - I was going off of Michael's postings
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Brin Chikovski I see what happened - you used a short-hand for the LEF's offering - it includes a pretty comprehensive metabolic panel of which CBC (Complete Blood Count) is only the last section of the list of analytes. But yes, this package covers all the required numbers you need for Phenotypic Age calculation.
As to the correlation being only 65%, see SUPPLEMENTARY FIG. S5 in Supplement 1 of the main DNAm paper:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111/bin/aging-10-101414-s001.pdf
(cor=0.65)
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aribadabar Michael Lustgarten posted a good overview of the various epigenetic clocks: https://youtu.be/iNnvF1Eh7VE
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