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Re: Turn-around in eosinophil counts after fisetin
My white cell count dropped from a high of 7.6 late last year (still within normal range) to 5.4 recently. My RC count didn't change.
- Koo
- 5 yrs ago
- Test Results Discussions
- Reported - view
Re: Turn-around in eosinophil counts after fisetin
@Karl Unfortunately my CRP hasn't been measured for many years - I know, it's weird! My last 3 blood tests for ESR were around the end of last year, there was a 4 year gap before this.…
- Koo
- 5 yrs ago
- Test Results Discussions
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Paul Beauchemin If you're taking them in oil and on an empty stomach, this can be a cause of diarrhea, as I found out the hard way 🙂 When I took senolytics in milk there were no negative side…
- Koo
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Mel Hi Mel, I'm new to this, but my feeling is that you should wait longer, at least a month before you have a blood test. This will give the fisetin time to have noticeable effects.…
- Koo
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Koo I've posted some interesting inflammatory cell count results from a blood test recently, which credit to fisetin. Have a look at my post in the "Test results" category.
- Koo
- 5 yrs ago
- Self-Experimentation
- Reported - view
Turn-around in eosinophil counts after fisetin

Here is an update on my experience taking fisetin, but first some background. I have fibrosis in one knee, it's a chronic low-grade inflammatory condition that involves the formation of excessive…
- Koo
- 5 yrs ago
- 5replies
- 443
- 1
- Test Results Discussions
Re: Fisetin to Clear Senescent Cells
@Ajax Thanks very much, that's good to know.
- Koo
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Ajax I would love to hear from anybody who dissolves fisetin in oil. How much oil are you using? I want to know if I was using way too much, it was around 60 mL,…
- Koo
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Ajax Thanks again for your feedback on having salicylate sensitivity. I finally plucked up the courage to try the coconut oil on its own yesterday, about 1/4 cup, and it wasn’t pleasant hehe.…
- Koo
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Trehalose

Has anybody researched or tried trehalose to kill senescent cells? I have just come across it in the literature, apparently it stimulates AMPK like Metformin does,…
- Koo
- 5 yrs ago
- 1reply
- 97
- Self-Experimentation
Re: Intro to rapamycin
@Laurence R I'm a newbie to this field of research, and I'm sure there are others that could answer you better. It seems to me that there are quite a lot of papers that demonstrate that rapamycin…
- Koo
- 5 yrs ago
- 3
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin
Another study on rapamycin his hit the news today, see https://www.eurekalert.org/pub_releases/2019-11/uoth-srp110619.php It shows that young mice given a daily dose of rapamycin preserve their good…
- Koo
- 5 yrs ago
- 2
- Rapamycin Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells
Thanks for the feedback, I really like the idea of trying fisetin in cream, I'll give that a try next week :-) I might also try the coconut oil on its own at some point,…
- Koo
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
Another thought, I wasn't paying any attention to my coffee drinking, so maybe there was an interaction between the fisetin and caffeine, which caused the heart effects.…
- Koo
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
Thanks Dan, that's interesting about milk. It's also 90% water, so probably a lot of the fisetin doesn't dissolve. Yes, it seems that I'm unusually sensitive to fisetin.…
- Koo
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
That's a good question! If I remember correctly other people have taken fisetin in coconut oil and not noticed significant side effects, maybe a burning throat was mentioned.…
- Koo
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
Regarding the availability of fisetin in oil, see my recent posts on the "Fiestin to Clear Senescent Cells" section. I can say with certainty that fisetin in coconut oil (MCT) has powerful and rapid…
- Koo
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
An update on my fisetin trial (above). This week I tried 300 mg of fisetin (Dr's Best) in warm milk, after a protein shake. There were no effects. The next day I decided to see what would happen if…
- Koo
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
Hi, Thanks for all the great posts and research, they have been very useful! I have some age-related conditions even although I'm not 60 yet and have always had a healthy diet and been very active.…
- Koo
- 5 yrs ago
- Self-Experimentation
- Reported - view

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