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Re: Metformin's effects on sex hormones?
Thank you Peter. Yes a lot of studies come up but they're all very small and short-term. I am unable to find an answer to the question of whether there are adverse hormonal effects in healthy…
- Adrian_M
- 4 yrs ago
- General Discussion
- Reported - view
Metformin's effects on sex hormones?

Hi all, Wondering if any of you can point me to information on the effects of metformin on estrogen and testosterone, esp in females. Asking since taking any exogenous hormones can raise your risk…
- Adrian_M
- updated 4 yrs ago
- 4replies
- 206
- General Discussion
Preventive Genetic Testing

What genetics tests would you recommend for the purpose of understanding your vulnerabilities - i.e. risks for conditions that might impact your lifespan or healthspan?…
- Adrian_M
- 4 yrs ago
- 24
- General Discussion
Re: Paul's self experimentation
@David H Thanks a million David for all the information and apologies for taking so long to respond. Hope you're well, keep us updated.
- Adrian_M
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Paul's self experimentation
@Moshe M. Hi Moshe, can you get it without a prescription? And any idea if they ship overseas? All the sources mentioned here are US based and I live in Europe.…
- Adrian_M
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Paul's self experimentation
@David H said: Adrian M YMMV, but I don't believe that hypoglycemia is a problem with metformin. Metformin works by reducing absorption of carbohydrates and by reducing the amount of fat converted…
- Adrian_M
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Paul's self experimentation
@David H Many thanks for this fascinating information, David! Yes, in the British Isles. That is great to hear, you had no side effects. I often have mildly upset stomach as is (I suffer from…
- Adrian_M
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Paul's self experimentation
@David H Thanks very much for the quick response. Isn't David Sinclair taking 1000 a day also? Pretty sure I've heard him say he takes 500 twice a day.…
- Adrian_M
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Paul's self experimentation
Hello, Paul, thanks so much for sharing. I'm very interested in taking metformin. I'm only in my mid-30's, avg body weight, but have a strong history of cancer (albeit not at particularly young…
- Adrian_M
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view

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