Cell Death Mechanisms Behind D+Q and Fisetin Senolytics

I don't seem to get as much reaction to D+Q as others.  While I've gotten a mild reaction several times, other times simply nothing.  Since I frequently take 3 grams of Lyposomal C, perhaps the C is clearing the reaction enough that I don't even notice.  So the question for me is whether the C is preventing symptoms, or preventing the senolytic action.  Next time I take D+Q I think I'll specifically avoid the C for a few days.

I only got a mild headache the day after D&Q and nothing from Fisetin. 

I have not tried D+Q yet. When I do Fisetin as single treatment I don’t feel any negative effects. But when I have tried Fisetin in combination with other substances I have felt unwell and had Headache and pain in muscles. (Different ombinations with Piperine/piperlongumines/tocotrienols/quercetin).

Yes it could be that fisetin starts a “cleaner” process. But I also speculate that the fluelike symptoms that is reported by D+Q users are a sign of effectiveness. And that kind of effect is also a common side effect of many anticancer treatments, (when an hopefully effective substance attacks unwanted cells).

The immune system cleans up the dead cells anyway no matter what senolytics you use. 

I get flu-like symptoms about 12 hours after taking D+Q, but I have no symptoms after taking fisetin. My guess is that D+Q kills more zombie cells than fisetin in my case.

I'm not a doctor, don't want to get in trouble. Consider this non-professional observation and guesswork. 

I researched for many months digging through studies and trying to understand mechanisms of action. I came to personal conclusions  and theories.

Dasa is a targeted cancer therapy and when used, you're trying to kill bad actors. Generally when trying to kill off a cell or organism it needs exposure to the poison for extended periods. Cells don't die immediately. If they did cancer treatments would be single dose. They are often a year. So the longer you're on, the better chance you kill the bad cells off. Having said that, there are side effects you want to mitigate. Changes in immune system, blood cell count, etc. From what I read blood begins to be affected on Dasa at 5 days so I chose a 3 day protocol. After testing my blood, I'd be comfortable going 4 as the changes after 3 days were very small and both of us 'felt' back to normal in less than 24hrs after drug cessation. Not sure 4 is needed because the results we got were very good after 3. I completely disagree with the protocol of one dose and another 2 weeks later but I admit, I have no expertise.

I did not expect to see results for 2-3 months if at all. We were shocked in that I saw the results after 3 weeks, she saw them at 5 weeks. I consider them dramatic. 

My protocol consisted of D&Q Fisetin Met Vit C, no sugar, raised fat diet. Any cell you want to kill dies quicker with a lack of fuel and metformin has synergistic affects in 2 known pathways. The problem She ran into was diarrhea. Bad. I suspect this was the flavonoids and C in someone not used to them and her not adhering to the higher fat diet required to bind to F&Q for absorption. You must eat and this therapy kills appetite. For future I will start Q C and F earlier to get the digestive system used to it. Same goes for Metformin which I believe should be run as high as safely possible. I was very conservative with it at 850/eve 500/morn. The blood sugar affects are immediate but other components linger in the system for many days. For this reason met should be started a week before therapy. It will help with stomach to ramp up dose too. 

My dasa was 60mg/pill and I swallowed 4 pills before bed. I didn't sleep. My head felt like it was going to crack open. I assumed that with an 18hr half life it didn't matter and I wanted drug in my system quickly. Rookie mistake. Day two I was a mess so I just took 1 pill afternoon. Sides were mild so I took another 3 hours later. I learned if you split the doses, it stays in the system the same but sides (esp headache) is vastly reduced. She started before me and didn't know this, my 2nd two days were better than the first 24 hrs.

Many people think Q or F are amazing senolytics and the Q combines with D for a double whammy. They may be helpful but largely the Q is added to the D because your body immediately adjusts to D and it's effectiveness starts diminishing immediately. The Q stops this. Q and F may be helpful but no one is going to reverse aging with them alone IMHO. 

In my next protocol I have adjusted many things and will have what I think is a much stronger cocktail with lower side effects. I've added coconut oil pills, another leukemia drug and reduced D dose. I'll report when I have data from myself and a group of people who saw what happened and may be following my lead. I don't sell anything and won't share details that could be legally gray. I don't provide anyone with meds just share what I'm doing and recommend no one copy me or take anything I say as advice of any kind. 

I tried High dose Fisetin first and felt nothing. It had no effect on my cycling power output or post-ride fatigue. I tried D&Q about 4 months later and had a mild headache (which is rare for me) and no other negative symptoms.   Two days after D&Q I did a hard ride and felt strong and felt very low post-ride fatigue. I was not expecting that. Ever since then I've gotten better power numbers and I fell great. I am almost certain it's the D&Q. I don't think fisetin does anything. Poor availability? 

I'm on day 4 of a 5 day x 1200mg fisetin regimen (planned for every 2 months per my doc), and both yesterday and today added 100mg 7,8 Benzoflavone, 100mg resveratrol + 10mg black pepper + 240mg r-lipoic acid + 290mg PS to the 1200mg fisetin.  Detox reaction / headache & vertigo for the last 3 hours, although yesterday wasn't as much of a headache.  Also consider the deep tissue massage received shortly after today's dose.  Also on 6mg rapamycin / week + 500mg Metformin ER x 2.