My 80 year old father's proposed regimen. What do you think?
Hi, I'd appreciate a few moments of your time. This is for my 80 year old father. He takes no prescription meds but is in rough shape due to his age and years of less than ideal lifestyle (which we are trying to correct).
At first I thought I'd put him on a good multi vitamin / mineral and a higher dose of ALA but then I decided to do a more comprehensive stack, hit it from all angles, using smaller dosages.
He would be taking all of the following once daily with his breakfast (he won't take anything on an empty stomach and neither will he remember to take anything more than once daily - so for compliance sake we settled on once a day with a meal). Here's what I came up with:
- multi vitamin / mineral formula (using Life Extension "Two - per - day" or "One - per - day" formula ---- same nutritional profile for both, which have extra B complex, E and tocopherols, D3 and all other vitamins / minerals in excellent doses and forms)
- Acetyl L Carnitine at 500 mg
- L Carnosine at 500 mg
- Rhodiola standardized extract at 500 mg
- Ashawandha standardized extract at 500 mg
- NAC at 500 mg
- Alpha Lipoic Acid at 300 mg
- EGCG at about 200 mg
- CO Q10 at about 100 mg
- K2 mk7 (as the above multi doesn't have K2) at 200 mcg
I might include omega 3 but hoping he will eat more fish because many supplements contain ethyl ester forms of the omegas and I'm not sure about that as far as safety and effectiveness vs getting the omegas from foods.
Anyway, if you have a minute or two, please comment or just give me a quick thumbs up. Thanks in advance.
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IMHO as an 86-year-old who is attempting to stay in good health, the items that is missing from your father's regimen are: (1) weekly doses of rapamycin, (2) daily doses of metformin, and (3) a 3-day big-dose session of senolytics (D+Q, Fisetin, etc.) every three months. When one reaches the 80s, the body's load of senescent cells is quite large, and the SASP these cells are generating creates many health problems. Clearing senescent cells with senolytics is perhaps the most effective thing you can do for your father.
There is lots of information on rapamycin, metformin, and senolytics, so I won't try to give details here on them, but you can easily find them. Rapamycin, metformin, and the dasatinib (D) used in some senolytic sessions are prescription drugs, but there are ways of dealing with that problem.
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JGC Thank you for your prompt and informative reply. Much appreciated.
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I note that you did not mention anything "exotic" and just plain old vitamins.
I would suggest that your father takes a daily pill of "Vitamin B complex", (on top of the vit B that comes with the multivitamin pill), with 100mg of nicotinamide (B3), on top of everything he is already taking.
Also very important he must go to the toilet to urinate "excessively" by drinking lots of water every hour.
Walking everyday from morning to evening is important.
Eating lots of different (varieties, not quantities) fruits, nuts, vegetables, roots and seeds is also very important.
You can Google the reasons for what I just said yourself. Search "microbiome" "plasma therapy" "exercise" "NAD+"
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Metformin 500mg twice a day
acarbose 50 mg with biggest 2 meals
I am 75 yo and use these
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Don’t understand the recommendations for Metformin. If he isn’t diabetic, there isn’t any solid evidence that metformin helps. Not worth the risks/side effects.
agree with Rapamycin.
Vitamin D and fish oil are a must.
magnesium a consideration.
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To what metformin side effects are you referring? I just did a web search, and the NIH lists the possible side effects as: nausea, diarrhoea, stomach ache, loss of appetite, and metallic taste in the mouth. All of these are rather subjective, and when I take 500 mg of metformin twice a day I experience none of them. The TAME trial now in progress promises to answer the question of whether metformin is beneficial for non-diabetics, but those results are not available yet. I view metformin as a chemical substitute for caloric restriction and an aid for weight control.
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JGC Lactic Acidosis. It’s a small risk, but with no proven benefit…..
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Metformin inhibits release of gonadal tropine releasing hormone and the subsequent production of DHEA, testosterone and estradiol. You can verify this with google search, and I attached a number of papers on these topics in previous posts to this forum. All of these hormones are essential in preventing sarcopenia, cognitive decline and sarcopenia in old flatulents like us. I note that the Tame trial includes DHEA supplementation which could lead to increase in testosterone and estradiol, although my reading of the proposal does not indicate this was the intent.
You will also find that calorie restriction has the same effect.
I also have severe doubts about rapamycin in seniors who have low levels of IGF-1as mTOR is needed in those of us who have low IGF-1 as I have.
My suggestion to the individual who posted about his fathers supplement stack is that he have his dad do LEF's most exhaustive blood work and see what is needed. This includes hormones and Omega 3/6 profile. You did not include high dose fish oil in your suggestions which is critical in suppressing inflammation, inhibits cognitive decline and also stimulates mTOR in preventing sarcopenia.
We are all different. What may be beneficial to some may not be for others. I expect that in the next 10 years or so, that AI will let each of us know what supplements to take based on genetics and blood chemistry.
I did not intend for these comments to be derogatory, and I have greatly appreciated your science based comments in the past.
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If you compare the side effects of metformin with the benefits, its not much of a contest, as reflected in the following recent article.
https://academic.oup.com/ageing/article/51/8/afac156/6653481?login=false
“There are many (>250) other studies and systematic reviews concluding that metformin can also reduce mortality, cancers, cardiovascular events, dementia and cognitive impairment
This combination of human clinical studies and preclinical data on the ageing effects of metformin, together with its established safety record led to metformin becoming one of the first drugs to be considered for human ageing trials. Led by Nir Barzilai, ‘Targeting Ageing with Metformin’ (TAME) is a 6-year, double blind, randomised, placebo-controlled diet evaluating metformin in 3,000 non-diabetic participants aged 65–80 years of age…. “
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See attached generalized comments on benefits of metformin in attached "Fight Ageing" article that was posted today. I can find many more detailed, peer reviewed if start search including adverse impacts on mitochondria.
There is no question that metformin significantly inhibits hormone production based on a number of publications . For a hypogonadal individual like myself, it is not beneficial-- and probably detrimental.
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Peter H. Howe "There is no question that metformin significantly inhibits hormone production based on a number of publications".
I wasnt aware of that. Do you have a link to some in vivo studies?
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Chuck Stanley: attached are copies of two papers, one for males and second for females ( breast cancer) These are two of many. I note that the study protocol you attached includes DHEA. My recollection was that the intent was to protect the immune system in persons being treated with metformin. Note also that DHEA supplementation also increases both androgens and estrogens as well as increases free testosterone, in addition to boosting the immune system ( some debate here).
http://publicationslist.org/data/nicoletta.biglia/ref-101/Metformin%202013.pdf
I started metformin several years ago and found a marked reduction in testosterone even though I supplement with androderm patches. I am severely hypogonadal and this resulted in high cholesterol and emergency bypass surgery 30 years ago. Long story on this issue.
The issue on mitochondria and ATP production is also a concern. You can google this and find a number of papers on this issue.
I must emphasize that each of us is different. What may be beneficial for some can be detrimental to others. As I indicated in my post to JPG, hopefully genetics, blood tests and AI will be able to determine what each of us must pursue for our individual health.
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Метформин понижава нивата на холестерола. По-нисък холестерол може да доведе до по-ниски нива на някои хормони. Този ефект е слаб и не се среща при много лица, защото това зависи от други фактори, както и. Въпреки това, ако се приема заедно с Рапамицин (което повишава нивото на холестерола), негативът се избягва. Това е една от връзките, които водят до добър синергистичен ефект на двете лекарства.
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Can you please repost in English. My Google translation didnt make sense.
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chuck stanley
Here's the translation: "Metformin lowers cholesterol levels. Lower cholesterol can be brought to a lower level for some hormones. Tosi effect is weak and not intersecting with a lot of faces, depending on other factors, such as. Contrary to this, if you take it together with Rapamycin (somewhat dependent on cholesterol), it’s negative. The product is one of a kind, which leads to a good synergistic effect on two drugs."
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JGC Yeh, that looks like the google translation I saw. 😊
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Sorry for the ridiculous translation!
Metformin and Rapamycin work great together.
They each have side effects, some of which are eliminated when both drugs are used at the same time.
