rapamycin cream

David H   wondered if you could provide a link or specific info as to the Doctors recipe for the Rapa cream. Thanks..

@Sally M  The doctor's name is Mark Thimineur and here is the link:

https://forum.age-reversal.net/t/364v6s?r=g9hqcvs

David H Thank you! 

Bruce B Thank you for doing the research and finding that link.  If you ever have time to provide your steps in sourcing Transcutol and Excipial Hydrocrème, please let me know.  And, of course, the details of your mixing process could save me a lot of time, too.  That pdf from that link seems to be the most efficient and safest way to proceed.   

Bruce B Would you mind telling us what parts of your body you use it on?  Face and hands, all over?

Thanks

Bruce B I read the pdf document from okina and noticed 

Table 2 Composition of rapamycin cream.

Component                    Quantity

Rapamycin                          0.03 g

Transcutol1                          1.5 g

Excipial Hydrocrème1 QS   30 g 

I'm sure I'm doing something wrong, but my simple calculation from this table is

0.03 g rapamycin / 31.5 g (transcutol1 + excipila hydrocreme qs) equals about 0.001 .  To me that means a 0.001% concentration of rapamycin in the cream, but the pdf document states that it is a 0.1% concentration.  If you have time do you have any thoughts on this.  Thanks.

Elizabeth  I was using it from the base of my neck all the way to my hairline, including face, and ears, also my hands. 

Bruce B also, what about adding fisetin and giving the cream a potential senescent cell-clearing effect?  At least in theory, rapamycin+fisetin should be an amazing one-two punch.

Bruce B dissolved 6mg rapa (from capsules) into 10ml of transcutol (stirred x 1 hour in magnetic stirrer per the study), then mixed 5ml into each of two 4-ounce jars of Cerave lotion.  Mixed perfectly, feels/smells just like Cerave lotion, and is 25 micromolar, which is the same concentration as that used by Dr. Mark Thimineur, although he uses DMSO as his solvent.  Transcutol is cheaper, extremely effective as a rapamycin solvent, enhances penetration into the dermis, and doesn't come with possible safety issues since it is specifically made and proven safe as a solvent for lotions/creams.  I also worry that DMSO is more likely to carry the rapa *through* the skin, which we don't want for our purposes -- we want it to penetrate into the skin but then stay there.

Bruce B as a fellow Canadian can you tell me what your rapamycin source is?  I can get the tablets but not the capsules to make a skin cream.  

Jared I used tablets for face cream, works fine.

Fred Cloud really?   Just grind them up with a pestle and mortar?

Jared Yes, exactly, just grind it up real fine and you should be ok.

Fred Cloud .  Great.  I’ll give it a go.  

Jared  I was getting mine through Alibaba, before they blocked rapamycin sales on their website to certain counties.  That being said the the place that was supplying it to me through Alibaba is shown at the link below.

Http://www.vanzpharm.com/en/search.html?type=title&key=rapamycin

Bruce B ok interesting. I wonder if I switch my country on alibaba if I’ll be able to see those ads.  

Bruce B I am visiting this topic again.  Does the skin cream mixture you formulated (GHK-CU peptides, carnosine, l-fucose, magnesium) also include rapamycin?  And, whether it does or not, are you still happy with it more so than simple rapamycin cream?  Thanks.