A hypothesis about Senescent Cells

My hypothesis is that a large proportion of Senescent Cells are in fact Stem Cells which have not differentiated properly.  What happens is they cause inflammation which causes a reduction in NF-κb which causes a reduction in SLC25A1 which reduces the number of citrate carriers which causes the differentiation of stem cells to fail more often and those turn in to senescent cells.

That therefore acts as a reinforcing error system that gets worse over time.  The interesting point is that Naked Mole Rats have few senescent cells.  I think that is because of HIF.

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