Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?

My wife and I eat natto (fermented soybeans) daily which contains a relatively large amount of spermidine.

================================================================

Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?

Autophagy. 2019; 15(1): 165–168.

Published online 2018 Oct 11. doi: 10.1080/15548627.2018.1530929

ABSTRACT

Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine concentrations and age-related deterioration has been suggested. Recent epidemiological data support this notion, showing that an increased uptake of this polyamine with spermidine-rich food diminishes overall mortality associated with cardiovascular diseases and cancer. Here, we discuss nutritional and other possible routes to counteract the age-mediated decline of spermidine levels.

===========================================================

Another article:

Cardioprotection and lifespan extension by the natural polyamine spermidine

Nat Med. 2016 December ; 22(12): 1428–1438. doi:10.1038/nm.4222.

AbstractAging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease. Our results suggest a new and feasible strategy for the protection from cardiovascular disease

109replies Oldest first
  • Oldest first
  • Newest first
  • Active threads
  • Popular
  • Do they sell the ‘defatted product’?

    Like
  • Wouldnt taking spermidine and rapamycin be redundant? Is there anything spermidine can do that rapamycin isnt already doing?

    Like
    • Fred Cloud Yes, redundant in the sense that they both show longevity effect and cognitive protection effect.

      Is the mechanism for spermidine benefits attributable to mTOR inhibition or is there something else going on? Could it be additive rather than redundant?

      Like 1
      • Fred Cloud
      • Fred_Cloud
      • 4 mths ago
      • Reported - view

      chuck stanley I just meant redundant in terms of autophagy. I think rapamycin does more than just autophagy but think spermidine may only offer autophagy. I do know autophagy is beneficial up to a point and then it turns negative so more is not better and rapamycin and spermidine may be too much. All the longevity studies on spermidine are people who arent taking rapamycin.

      Like
    • Fred Cloud 

      I see what you are saying. If we aren’t careful we could be over inducing general autophagy which could have detrimental effects. Or we could be combining compounds that target the same tissues and getting too much autophagy.

      Hopefully with a multiple approach we are instead inducing selective autophagy of different targets, and providing overall long-term health benefits.

      There are different modes of action between the autophagy inducers that extend healthspan and increase lifespan, at least in laboratory animals: metformin, rapamycin, resveratrol, NAD+ precursors, and spermidine all have somewhat different modes of action. Additionally, some of the other supplements we take, such as fisetin contribute to the regulation of autophagy. I sure don’t know to what extent there is overlap in the target tissues that are affected by the various approaches. So unless we have expert guidance, it makes sense to be conservative in our doses and scheduling when combining these inducers.

      Like 1
    • Fred Cloud I think the point about redundancy in multiple approaches toward the same result is an often overlooked but very important concept since redundancy can potentially be detrimental. 

      But in answer to your question, I believe there is one thing that spermidine does which seems to at least be more difficult with rapamycin. How about crossing the blood brain barrier? It has been shown that spermidine crosses BBB in old mice and also in adult humans. I believe it was 1.2 mg in the study that showed cognitive improvement in adult subjects, whereas Blagosklonny cautiously increased his rapamycin dosage to 20 mg (now 24mg) biweekly, ostensibly in attempt to cross the BBB. 

      Like
  • Has anyone else had trouble with Botany.com orders?

    I bought 2 jars of spermidine, supposed to contain 500 mg each. One jar contained 492 mg, the other jar contained only 438 mg. Also the powder was lumpy, though that didn’t concern me so much. 

    I sent an inquiry to customer support. Three days later I received a response which argued with me and asked if I was using a calibrated .001 scale.  I replied that yes I was and that I could send them a picture of the powder on the scale with the readings.  But they never responded. 

    Usually I find that powders are over, not under. 

    Is it Buyer Beware with Botany or was my experience a fluke?
     

    Like
    • chuck stanley Botany.bio

      Like
    • chuck stanley 

      I've had a few issues with them as well, some relating to things being underweight. To put such a small amount in a container loose so it all sticks on the sides is crazy. I have 2 new containers of their spermidine as well and will weigh mine to double check. They and their parent company are closing soon, and their customer service lately has been terrible. 

      Like
  • Jay Donovan chuck stanley How are you consuming it? With water or smoothie or something else?

    Like
    • Hello World I've been just weighing 50mg and taking it with some food and a some other supplements. I take it about 3 times a week. 

      Like
    • Hello World but just tossing the powder in my mouth and washing it down with water. 

      Like
    • Hello World , I diluted with lactose 100:1 and add a little scoop of the mix (~12 mg spermidine) to my smoothie. It has no taste and if it sits in the smoothie for hours it still has no taste (unlike raw wheat germ which gets a little strong if it sits around).

      Like
  • I've been using this for about a month.  Does anyone know how bio-available this chlorella source is compared to the wheat germ sources? 

    Like
  • I just bought 500 g of Spermadine with the intention of using 10 g/d. I will report how it goes

    Like
    • David McCallister Why so much per day? May I ask where you got it from?

      Like 1
      • Fred Cloud
      • Fred_Cloud
      • 2 mths ago
      • Reported - view

      David McCallister I assume you actually mean milligrams not grams, right?

      Like
    • Fred Cloud no, I did not make a mistake. I mean grams. I am a member of a nootropics group who is experimenting with several things at anyone time. We have chemists who synthesize some products, doctors who advise, facilitators who make things happen including group buy ( the spermidine comes from a group buy). I plan on splitting my portion with another member in the US here who is also interested in longevity. 

      Like
    • David McCallister 

      Extremely interesting! I’ve been wondering if there weren’t some way to organize group buys, using an escrow service, such as on Ali Baba, to hold our payments, and testing facilities for verification of product.

       Although I haven’t personally seen the rationale to consume more than 12 mg spermidine a day, (I am a fairly conservative biohacker), I would welcome an opportunity to benefit from belonging to a buyers group. Is any membership open?

      Some products, spermidine, Ca-AKG, NMN, are priced pretty high for the amounts an average but conscientious experimenter would be taking.

      Like
      • Fred Cloud
      • Fred_Cloud
      • 2 mths ago
      • Reported - view

      David McCallister Why take so much? 10mg a day should be plenty but 10 grams would be 1,000 times higher dose.

      Like
    • Fred Cloud 

      Like
    • David McCallister can I ask about this group? Was it the one that got shut down by discord in the last month? These groups are where a lot of real progress is being made. 

      Like
    • Arizona Kid yes, it was. We’re back up and going….on our own. We will not be hosted by an outside source again

      Like
    • David McCallister 

       

      What's dead may never die! Viva la discord :) 

      Like 1
    • David McCallister 

      I was part of that too by the way haha. Different user name. But I have a bunch of bulk spermidine and rapa

      Like
    • Jay Donovan still waiting on mine. Seems to be stuck in Chicago

      Like
  • Does anyone know of a gluten free version? Premeadine is a wheat germ extract. 

    Like
    • Ronan Harrington Yes, you may be interested in this.

      Like
    • Ronan Harrington 

      I can send you a source for pure spermidine trihydrochloride powder later tonight. No gluten. Just in the middle of something there now. 

      Like 2
Like3 Follow
  • 3 Likes
  • 2 mths agoLast active
  • 109Replies
  • 1376Views
  • 27 Following