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Jennifer Klein
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Dan
Thanks Dan. I did not know that there is a specific substance in green tea that can effect stomach in that way. I can have gotten used to it.
I drink plenty of green tea and quite strong. And usually I take some c-vitamins with green tea - first thing in the morning. Lately I add quercetin to reap the potential synergies with Q. Then some time ago I also tried to add double dose of mega green tea extract to the tea. And that combination did not affect my stomach at all. But when I first tried strong green tea extract (EGCG) I felt really nauseated. Maybe I have gotten used to green tea, as you say is possible.
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Edward Sutherland To answer some of these questions, I never or rarely suggest taking the manufactures recommendations in terms of several capsules of anything a day. I think a slower, more constant infusion of the agents allows for an improved risk/ benefit ratio.
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sandra kaufmann Is there benefit/risk to emptying the capsules and mix as a smoothie, with the remaining agents? Thank you
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Michael As long as they are soluble in whatever you are putting them in, it should be fine. Keep in mind, some of these things taste terrible!!
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sandra kaufmann
Thanks for emailing me!
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This is Dr. Kaufmann of the Kaufmann Protocol. I would love to hear feedback about anyones experience so that I can tweak the system to make it even better! I am continuously looking at new agents ( it takes a while per agent) and will be posting up too date info on the website. KaufmannProtocol.com
I regret that folks are struggling with so many pills, but at the moment there are no other options- But I'm in the same boat, and I'm working on a solution!
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sandra kaufmann
So great to have you in the forum Dr. Sandra.
Talking about the possible interaction of the different molecular agents, are there any supplements/adjuvants in the protocol that should not be taken together as they may cancel each other's benefit?
As for the relative inconvenience of taking so many pills, I still prefer that to the pricy, unaffordable unpractical methods like NAD infusion, Stem cell therapy, or young blood transfusion.
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Jennifer Klein
Things don't exactly cancel each other out, but if you are going to take several anti-oxidants, I would spread them out over the day. The half lives of these are usually in the 4 to 8 hour mark, so that by late afternoon/evening you still have some coverage.
And I agree, the cost of the other treatments is a bit ridiculous at the moment!
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sandra kaufmann great to see you here, thanks for joining.
On the ALA I'm glad to see it in your protocol, but are you aware of Dr Bruce Ames (nee Ames Test) work on this and ALC? His research is published and there are also videos on YouTube (linked below) where he gives a talk on this. The point being is that he found while ALA addresses some part of mitochondrial aging, if you combine it with ALC (Acetyl-L-Carnetine) you'd address the rest of it. The two were necessary, and in mouse models he was able to get old mice to nearly as well as young with these two together.
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sandra kaufmann I started the PANACEA one month ago. I'm 59, I'm a lean endurance runner and free thinker, I feel better in both area. More endurance and I'm sharper. I also can sleep less... but I wonder if it is really a good news? Also I had a Seborrheic Keratosis on my head, doctor told it was not here to dessapear, but it did (Could it be the Astaxanthin?).
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Excellent questions! Your body is going to naturally titrate the amount of sleep that you require. If your cells are becoming optimized and getting what they require with less sleep, then great! In general however, most older folks get too little sleep stemming from a sirtuin deficiency which then gets reversed on the protocol and they can finally sleep. In terms of the keratosis, it has components of an inflammatory nature, so both the astaxanthin and the curcumin should help.
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sandra kaufmann This is great to hear. I'm having sleep issues at the moment - typical mid life stuff and probably also aging itself. For focusing on sleep specifically what supplements would you recommend?
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Dan You need to boost your sirtuins with either pterostilbene or resveratrol, and then make sure you are getting enough NAD replacement.
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sandra kaufmann
I have had sleep issues as well, now I sleep like a baby. I do take both Resveratrol and Pterostilbene, then I take NAD and Melatonin every night, all within your recommended dosing. It works like a charm but I hope I am not overdoing it.
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sandra kaufmann Got all that covered thanks, fortunately it's doing much better, was other issues ... Another good one for sleep is 5-HTP, a serotonin precursor, before bed, and a magnesium to help relax the muscles.
By the way, FWIW your suggested melatonin doses give me a 'melatonin hangover'. I tried them long before reading your book, they're common recommendations and most of the supplements come in these sizes, but they're like sledgehammers. They put me down so deep I don't dream and probably don't get any REM. I use the 300 microgram time release from LE which is pretty perfect, and even at that I'll drop it for a few days every other week or so.
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Dan I see that every person is a world and reacts differently to medicine/supplements/adjuvants. Me Melatonin gives me way to many dreams... sometimes I have a feeling I have been dreaming the whole night. So at times I get worried that I am getting too much of the REM Sleep and too little of the deep sleep.
I take 4 mg each night and for almost a year now.
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Jennifer Klein Exactly - yeah I can't even imagine 4 mg! I've always been a great sleeper so maybe produce a lot of melatonin already.
Reminds me of another one for sleep which is Glycine, an amino acid I believe. Hibernating bears have loads of it in their brains. Take it before you sleep and you'll have great dreams.
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Dan
I like to mention that I get a good night’s sleep from 300-400 mg standard folic acid that is taken before I lay down in bed. I take it alone or with different kinds of magnesium. But no effect from magnesium threonat, which does not not improve my sleep.
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Staffan Olsson magnesium is just a muscle relaxant I believe, similar to taking an epsom salt bath. I don't find it a huge effect but it does seem to help.
Speaking of which since we've veered into talking about sleep, I've found relaxation exercises to work wonders. I use the Muse EEG headset and their meditation programs to relax the body and calm the mind an hour or two before bed. Really does wonders.
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Dan
Men in general sleep better than women, maybe it's the testosterone. Your endogenous production of Melatonin must still be good. I know I don't have much left . I do prefer Melatonin to all the other sleep aids because I also want to get the anti-aging benefits it has, the dosing of which (in the protocol) starts at 3 mg.
Here is an anecdote for you: I went to my doctor a few years ago to get some help for my sleep problems and she told me that I could take Melatonin up to 30 mg/night that she herself was taking with no problem. She prescribed 10 mg for me to start with (have been taking smaller doses before) and build up to higher doses but my body didn't like it so I stopped. So my happy medium now after trial and error is the 4 mg.
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Jennifer Klein Good info thanks. My wife's hormones crashed a bit ago in her 50's and she wasn't sleeping. Her doctors told her that Progresterone promotes good sleep. Once she was on that and estrogen it cleared up, and she also uses the 300 mcg that I use.
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Jennifer Klein Awesome!!! It takes about a month for the SIRTUINS and NAD to kick in to improve the circadian rhythms. And no, you are not overdoing it!
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I have been on the panacea since November, but kicked it into high gear in January with the addition of most of the tier two suggested supplements/adjuncts on the Kaufmann app. I have never felt,looked, or performed better. Dr Kaufmann does not link anti-aging with athletic performance, but I am proof positive that her protocol is making a huge difference for my cycling endeavors. If anyone follows "strava" you can see that I have claimed 'KOM" (king of the mountain..fastest times) on many routes since January. I know Dr Kaufmann has developed the NFL playbook (patent pending) for athletes, but look at the additional supplements and most of them are part of the playbook (spoiler alert, sorry Dr K)!!
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charles smith I've also noticed athletic differences. Been running/cycling for decades but nothing special, 30min on an exercise bike and a 4 mile run on the weekend. However my VO2max is 50 - equivalent of a college athlete. I'm 53! During a run I can carry a conversation. I can only attribute this to the healthy living and supplementation.
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Dan I feel ya! However, as you mention, and as Dr Kaufmann notes repeatedly in her book, the supplementation and antiaging protocol is not about diet and exercise, but I feel a lifestyle of consistent exercise and moderation in diets, gives you amazing results. I just wish I had read Dr k's book a decade ago!! As with everything in life, I believe consistency is the key ( along with the protocol, of course)
You Go College Man !!
Charles
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