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Reading the book now. Have not started the protocol yet. Tell me your results please
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Thank you for your answer, I am female, 57 and have been taking practically all the recommended molecular agents for 10 months now. My results: definitely more energy, far better sleep, better mental sharpness, probably better skin, lost weight eating the same (didn't have any big issues with weight to start with but still lost about 3 kg) and a good overall feeling (maybe only due to the fact I am doing something against aging). The cons: loads of pills to swallow.
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I'm getting the book soon and will use it to create a program for us. I've got a number of supplements we take already but it's a hodgepodge made up of what we happened to come across reading the research on our own. I'm hoping to use it to trim down what we're doing and cut the cost of the supplements.
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Dan That would be great, looking forward to getting this new program. In the meantime, where can I find a list of those anti-aging supplements you guys are taking already?
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Jennifer Klein I have a post somewhere detailing but I can't seem to find it. Anyhow the core is NAD, ALA/ALC, Phosphatidylcholine, CoQ10 (Ubiqinol), Quercetin and Resveratrol (enhanced by having taken a NAD regime). Those are the core ones, we take a amino acids to fill in since we're vegan (creatine and another), the rest is mainly plant derivatives.
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Dan Thanks Dan, many of the supplements/adjuvants that you mentioned are included in the Kaufmann Protocol. Amino acids -as Leucine- are included too to prevent sarcopenia in the case of taking Metformin. Looking forward to your feedback once you read the book.
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Jennifer Klein OK! Thanks for the encouragement, I've been meaning to get around to it and just got the Kindle version. Perusing it this is fantastic, I'm a engineer (nee scientist) so appreciate her digging into the details.
For the ALA/ALC look up Bruce Ames who created the Ames test, which is what is used to detect the effect of (e.g. carcinogenic) compounds on it. There's several videos of him showing the research, this one isn't great but anyhow the point is that the combination of ALA and ALC restores mitochondrial energy production to youthful levels in mice, but fixing the CoQ10/etc production mechanism.
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Dan Thanks Dan for the video, I will look up more videos and do more reading about the ALA/ALC combination.
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Jennifer Klein Yes specifically the two together address mitochondrial disfunction, ALC by itself only addresses part of that problem. One thing to note is you need to have sufficient biotin in your diet or supplementation, they found some people with low biotin could suffer from skin flushing.
Otherwise I've done a scan of her book. Excellent work, not as expansive as I expected - I had thought she'd cover more supplements, but she certainly has all the big guns in there. On effects I've talked about I do notice a drop in 'pep' when I go off of them. (Pure anecdotal hand waving) - it could be placebo but I don't think so, it appears to be that without the supplements my general pep goes down, presumably from the mitochondria not functioning as well. Example of this was a period were I simply forgot to take my supplements and didn't notice, but I did notice a drop in energy and focus. Resuming fixed it and my energy came back.
In terms of this the ones that make the biggest difference, that I notice, is ALA/ALC, CoQ10 and PtC.
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Dan There are so many anti-aging supplements and adjuvant out there that one is confused and at loss about what to take. So when I came across this protocol that addresses all aspects of aging, I found in it a perfect guide to what to take. I hear that the doctor is expanding the protocol and up to now there are over 30 molecular agents targeting all the different cellular damage caused by time. There will even be more that she is still working on. So for now I will stick to this list and to date, other than noticeable general improvement (specially energy-wise) I have nothing negative to say about it (other than the inconvenience of too many pills to pop. All the same I appreciate your comments about ALC, CoQ10 and PTC that are not included in the Protocol ... so far.
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Dan Thanks for reading the book! The list in the book is only 15 of the Agents. There are 30 on the website, KaufmannProtocol.com, and I am constantly working to expand the list.
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Hello, I have been doing the Kaufmann protocol "panacea" for a few months now and one result has been to rid myself of inflammation in my right shoulder, that I had for years. I corresponded with Dr. Kaufmann already, and she suggested adding EGCg (green tea extract) to the protocol which I have done. I do not know if there will be many noticeable effects in the near future, but just the idea that it will be possible to outlive my expected expiration date is a huge turn on for me! It is hard for me to remember to take all the capsules in a day so I put all the days ration in one little vial that I carry around with me. A challenge is travelling and taking the immortality supplements along. It can be quite an ambitious task explaining to customs agents that all the 200 colored capsules you are carrying are just your one week ration for age reversal!
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Edward Sutherland I know exactly what you're talking about with so many pills to take and carry around when not home. I also have that good feeling of doing something to prevent the degeneration that comes with age and not just stand still arms folded. My knee pain is still there but with less intensity and I am hopeful it will eventually disappear altogether. I do take all the anti-inflammatory agents on the protocol. Sometimes I worry whether all those pills are bad for the liver and the kidney. I will soon have some blood tests done and I really hope to see some good results.
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Edward Sutherland I realize that the plethora of capsules is a pain in the butt! I just ordered the most awesome containers for folks that want to be organized and/or travel a lot to make life a little easier for everyone. I'll post a pic when they arrive.
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sandra kaufmann Great idea, maybe it would be possible to put on a sticker like "Notice, contains anti-aging food supplements for personal use only" to soothe customs agents !!
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sandra kaufmann That is a great idea indeed and I hope there will be for international shipping as well.
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Edward Sutherland You can temporally come off some of the pills when travelling - it's even recommended such as with Carnosine - and only take the basics "Panacea. This doesn't work of course if you travel most of the time and in this case good luck with the customs agents.
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Edward Sutherland excellent idea!
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Jennifer Klein
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Jennifer Klein Yes, the possible side effects and the interaction of the different molecules are a source of concern for me also. Since the supplements I am taking are getting stronger and more potent over time I watch what I take and when. I would never take a high potence Curcumin on an empty stomach for example. Not only liver and kidney, but the whole intestinal tract can be influenced. If I get a bad stomach upset then I take nothing that day anymore for a precaution. The problem now is still that the thresholds for efficacy of many age reversal products are not yet known, so different companies recommend starkly differing dosages !
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Edward Sutherland Indeed, it is a bit of a gambling game we are playing here, still I believe it is better than sitting back and do nothing. Both my parents had bad old age with an array of many degenerative diseases. They did have the healthy Mediterranean diet and were quite active, but it still caught up with them. So just a healthy lifestyle is not enough... Of course there maybe interactions and side effects with all those molecular pills... we should each do our homework and research and maybe also help each other with remarks and feedback.
Curcumin should be taken with meals, its best absorbed with fatty food, also with black pepper I read. Me, the green tea extract on an empty stomach upsets it, yet it should be taken that way, so it is then up to me to decide.
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Edward Sutherland If there's bad interactions between supplements then you might as well ask why there aren't the same between all the different parts of food. Eat an Indian dish, I make one and count some 20 ingredients, 1/4 of which are spices. It's vegan, so these are all plants with hundreds of different molecules in each. Plus we add other vegetable sides. A handful of supplements is swamped by the variety of molecules we get from a varied diet.
On supplements, FWIW I'm a decent exerciser, but only do 4 miles a week on the track and the rest of the week 1/2 hour on a stationary bike, plus some Pilates. Yet I run with a buddy who has been doing it his whole life and was competitive, plus daily swimming and biking. Interestingly I'm the one carrying the conversation, he can't run and talk but I can, even though he's the super athlete compared to me. What's different is I'm careful about what I eat and do a lot of supplements/NAD/Metformin and so on. Anecdotal, but I've found that yes it does have impact, as long as you are checking all over your other boxes (diet, exercise, sleep, relationships, creative work, etc).
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Jennifer Klein
Hi!
I have also experienced an upset stomach when I took Green tea extracts (EGCG mega extract) on empty stomach. I could reduce the discomfort in a few ways.
- Take the extract after a cup of real green tea.
- Take the extract with quercetin. (I only use the Quercetin Phytosome).
- Do not use extract at all but try to increase absorption from real green tea in a radical way and drink a fair amount of green tea and:
Drink real green tea on empty stomach and together with a small amount of vitamin C and piperine/black pepper and quercetin.
+ Let the tea water reach boiling before you pour it into the teacup.
+ Let the tea leaves spend a long time with the tealeaves.
As far as I have read these are measures to draw more catechins out of the tea leaves and to get a better absorption from real green tea. Otherwise, when it only comes to prepare a good cup of tea, they don't recommend that green tea should be prepared by using boiling water and they usually recommend that the tea leaves only to be a short time with the leaves. But the longer time and the higher the temperature the more of the healthy substances will come into the tea.
Vitamin C, piperine and quercetin seems to increase the absorption of real green tea. And therefore it is easier to get a meaningful amount of EGCG and other catechins from drinking green tea. I would like to mention that some time ago I wanted to try green tea extracts again.
Then I took the extract with quercetin phytosome and also this time It did not upset my stomach. it is also anecdotal but these are my personal experiences and also based on the information I have been able to find.
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Staffan Olsson Not surprised about the stomach upset - green tea in its native form is known to give people upset stomachs, never mind concentrating it. There's a chemical in there that a significant portion of the population is sensitive to, I forget the name of it. You can get used to it, when I first started drinking green tea decades ago after discovering it in Japan I could get a bit of a stomach upset, but that disappeared eventually. Don't know if that's possible with a pill - my answer would be to just drink it straight.
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Staffan Olsson Thank you for your tip, also thank you Dan. Green tea contain tannin which is a beneficial antioxidant but does irritate the stomach. I had to try many brands until I found one that doesn't upset my stomach. I try to take green tea in both forms, the extract in pills and the brewed leaves and yes I make sure it is strongly brewed even if it gets bitter and upsets the stomach more. It's very true that you get used to it after some time and the discomfort is minimum. Sometimes I eat a piece of fruit first then the tea, and it works, and if you say that vitamin C helps with the absorption then even better.
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