Kaufmannprotocol

Jennifer Klein I have a post somewhere detailing but I can't seem to find it. Anyhow the core is NAD, ALA/ALC, Phosphatidylcholine, CoQ10 (Ubiqinol), Quercetin and Resveratrol (enhanced by having taken a NAD regime). Those are the core ones, we take a  amino acids to fill in since we're vegan (creatine and another), the rest is mainly plant derivatives. 

Jennifer Klein OK! Thanks for the encouragement, I've been meaning to get around to it and just got the Kindle version. Perusing it this is fantastic, I'm a engineer (nee scientist) so appreciate her digging into the details. 

For the ALA/ALC look up Bruce Ames who created the Ames test, which is what is used to detect the effect of (e.g. carcinogenic) compounds on it. There's several videos of him showing the research, this one isn't great but anyhow the point is that the combination of ALA and ALC restores mitochondrial energy production to youthful levels in mice, but fixing the CoQ10/etc production mechanism. 

Jennifer Klein Yes specifically the two together address mitochondrial disfunction, ALC by itself only addresses part of that problem. One thing to note is you need to have sufficient biotin in your diet or supplementation, they found some people with low biotin could suffer from skin flushing. 

Otherwise I've done a scan of her book. Excellent work, not as expansive as I expected - I had thought she'd cover more supplements, but she certainly has all the big guns in there. On effects I've talked about I do notice a drop in 'pep' when I go off of them. (Pure anecdotal hand waving) - it could be placebo but I don't think so, it appears to be that without the supplements my general pep goes down, presumably from the mitochondria not functioning as well. Example of this was a period were I simply forgot to take my supplements and didn't notice, but I did notice a drop in energy and focus. Resuming fixed it and my energy came back.  

In terms of this the ones that make the biggest difference, that I notice, is ALA/ALC, CoQ10 and PtC. 

Dan Thanks for reading the book! The list in the book is only 15 of the Agents. There are 30 on the website, KaufmannProtocol.com, and I am constantly working to expand the list.

Edward Sutherland I realize that the plethora of capsules is a pain in the butt! I just ordered the most awesome containers for folks that want to be organized and/or travel a lot to make life a little easier for everyone. I'll post a pic when they arrive. 

sandra kaufmann  Great idea, maybe it would be possible to put on a sticker like "Notice, contains anti-aging food supplements for personal use only"  to soothe customs agents !!

Edward Sutherland excellent idea!

Jennifer Klein  Yes, the possible side effects and the interaction of the different molecules are a source of concern for me also. Since the supplements I am taking are getting stronger and more potent over time I watch what I take and when. I would never take a high potence Curcumin on an empty stomach for example. Not only liver and kidney, but the whole intestinal tract can be influenced. If I get a bad stomach upset then I take nothing that day anymore for a precaution. The problem now is still that the thresholds for efficacy of many age reversal products are not yet known, so different companies recommend starkly differing dosages !

Edward Sutherland If there's bad interactions between supplements then you might as well ask why there aren't the same between all the different parts of food. Eat an Indian dish, I make one and count some 20 ingredients, 1/4 of which are spices. It's vegan, so these are all plants with hundreds of different molecules in each. Plus we add other vegetable sides. A handful of supplements is swamped by the variety of molecules we get from a varied diet. 

On supplements, FWIW I'm a decent exerciser, but only do 4 miles a week on the track and the rest of the week 1/2 hour on a stationary bike, plus some Pilates. Yet I run with a buddy who has been doing it his whole life and was competitive, plus daily swimming and biking. Interestingly I'm the one carrying the conversation, he can't run and talk but I can, even though he's the super athlete compared to me. What's different is I'm careful about what I eat and do a lot of supplements/NAD/Metformin and so on. Anecdotal, but I've found that yes it does have impact, as long as you are checking all over your other boxes (diet, exercise, sleep, relationships, creative work, etc). 

Jennifer Klein 

Hi!

I have also experienced an upset stomach when I took Green tea extracts (EGCG mega extract) on empty stomach.  I could reduce the discomfort in a few ways.

-          Take the extract after a cup of real green tea.

-          Take the extract with quercetin. (I only use the Quercetin Phytosome).

-          Do not use extract at all but try to increase absorption from real green tea in a             radical way and drink a fair amount of green tea and:

Drink real green tea on empty stomach and together with a small amount of vitamin C and piperine/black pepper and quercetin.

+ Let the tea water reach boiling before you pour it into the teacup.

+ Let the tea leaves spend a long time with the tealeaves.

As far as I have read these are measures to draw more catechins out of the tea leaves and to get a better absorption from real green tea.  Otherwise, when it only comes to prepare a good cup of tea, they don't recommend that green tea should be prepared by using boiling water and they usually recommend that the tea leaves only to be a short time with the leaves. But the longer time and the higher the temperature the more of the healthy substances will come into the tea.  

Vitamin C, piperine and quercetin seems to increase the absorption of real green tea. And therefore it is easier to get a meaningful amount of EGCG and other catechins from drinking green tea. I would like to mention that some time ago I wanted to try green tea extracts again.

Then I took the extract with quercetin phytosome and also this time It did not upset my stomach. it is also anecdotal but these are my personal experiences and also based on the information I have been able to find. 

Staffan Olsson Not surprised about the stomach upset - green tea in its native form is known to give people upset stomachs, never mind concentrating it. There's a chemical in there that a significant portion of the population is sensitive to, I forget the name of it. You can get used to it, when I first started drinking green tea decades ago after discovering it in Japan I could get a bit of a stomach upset, but that disappeared eventually. Don't know if that's possible with a pill - my answer would be to just drink it straight. 

Dan 

Thanks Dan. I did not know that there is a specific substance in green tea that can effect stomach in that way. I can have gotten used to it.

I drink plenty of green tea and quite strong.  And usually I take some c-vitamins with green tea - first thing in the morning. Lately I add quercetin to reap the potential synergies with Q. Then some time ago I also tried to add double dose of mega green tea extract to the tea. And that combination did not affect my stomach at all. But when I first tried strong green tea extract (EGCG) I felt really nauseated. Maybe I have gotten used to green tea, as you say is possible.

Edward Sutherland To answer some of these questions, I never or rarely suggest taking the manufactures recommendations in terms of several capsules of anything a day. I think a slower, more constant infusion of the agents allows for an improved risk/ benefit ratio.

sandra kaufmann Is there benefit/risk to emptying the capsules and mix as a smoothie, with the remaining agents? Thank you

Michael As long as they are soluble in whatever you are putting them in, it should be fine. Keep in mind, some of these things taste terrible!!

sandra kaufmann 

Thanks for emailing me!

Jennifer Klein 

Things don't exactly cancel each other out, but if you are going to take several anti-oxidants, I would spread them out over the day. The half lives of these are usually in the 4 to 8 hour mark, so that by late afternoon/evening you still have some coverage. 

And I agree, the cost of the other treatments is a bit ridiculous at the moment! 

sandra kaufmann great to see you here, thanks for joining. 

On the ALA I'm glad to see it in your protocol, but are you aware of Dr Bruce Ames (nee Ames Test) work on this and ALC? His research is published and there are also videos on YouTube (linked below) where he gives a talk on this. The point being is that he found while ALA addresses some part of mitochondrial aging, if you combine it with ALC (Acetyl-L-Carnetine) you'd address the rest of it. The two were necessary, and in mouse models he was able to get old mice to nearly as well as young with these two together. 

 sandra kaufmann I started the PANACEA one month ago. I'm 59, I'm a lean endurance runner and free thinker, I feel better in both area. More endurance and I'm sharper. I also can sleep less... but I wonder if it is really a good news? Also I had a Seborrheic Keratosis on my head, doctor told it was not here to dessapear, but it did (Could it be the Astaxanthin?). 

sandra kaufmann This is great to hear. I'm having sleep issues at the moment - typical mid life stuff  and probably also aging itself. For focusing on sleep specifically what supplements would you recommend? 

Dan You need to boost your sirtuins with either pterostilbene or resveratrol, and then make sure you are getting enough NAD replacement. 

sandra kaufmann Got all that covered thanks, fortunately it's doing much better, was other issues ... Another good one for sleep is 5-HTP, a serotonin precursor, before bed, and a magnesium to help relax the muscles. 

By the way, FWIW your suggested melatonin doses give me a 'melatonin hangover'. I tried them long before reading your book, they're common recommendations and most of the supplements come in these sizes, but they're like sledgehammers. They put me down so deep I don't dream and probably don't get any REM. I use the 300 microgram time release from LE which is pretty perfect, and even at that I'll drop it for a few days every other week or so. 

Jennifer Klein Exactly - yeah I can't even imagine 4 mg! I've always been a great sleeper so maybe produce a lot of melatonin already.

Reminds me of another one for sleep which is Glycine, an amino acid I believe. Hibernating bears have loads of it in their brains. Take it before you sleep and you'll have great dreams. 

Dan 

I like to mention that I get a good night’s sleep from 300-400 mg standard folic acid that is taken before I lay down in bed. I take it alone or with different kinds of magnesium. But no effect from magnesium threonat, which does not not improve my sleep.

Staffan Olsson magnesium is just a muscle relaxant I believe, similar to taking an epsom salt bath. I don't find it a huge effect but it does seem to help. 

Speaking of which since we've veered into talking about sleep, I've found relaxation exercises to work wonders. I use the Muse EEG headset and their meditation programs to relax the body and calm the mind an hour or two before bed. Really does wonders. 

Jennifer Klein Good info thanks. My wife's hormones crashed a bit ago in her 50's and she wasn't sleeping. Her doctors told her that Progresterone promotes good sleep. Once she was on that and estrogen it cleared up, and she also uses the 300 mcg that I use. 

Jennifer Klein Awesome!!! It takes about a month for the SIRTUINS and NAD to kick in to improve the circadian rhythms. And no, you are not overdoing it!

charles smith I've also noticed athletic differences. Been running/cycling for decades but nothing special, 30min on an exercise bike and a 4 mile run on the weekend. However my VO2max is 50 - equivalent of a college athlete. I'm 53! During a run I can carry a conversation. I can only attribute this to the healthy living and supplementation. 

Dan I feel ya!  However, as you mention, and as Dr Kaufmann notes repeatedly in her book, the supplementation and antiaging protocol is not about diet and exercise, but I feel a lifestyle of consistent exercise and moderation in diets, gives you amazing results.  I just wish I had read Dr k's book a decade ago!!  As with everything in life, I believe consistency is the key ( along with the protocol, of course)

You Go College Man !!

Charles

charles smith I can't find you on Strava. Do you use your own name? 

Larry 

Larry There are a billion Charles Smiths!! Try Charles smith san Antonio, that should narrow it down.!

Dan There are definitely things we should be on that do not necessarily help you stop aging, but help with overall health. The list above looks pretty good- But I would add Leucine, Collagen, hyaluronic acid and a general vitamin.

sandra kaufmann et. al.

Followup, in David Sinclair's new book he discusses how certain Amino Acids - prevalent in animal foods, promote the aging process via mTOR (c.f. p99*). Current thinking is that it's nutrient sensing that tells our system whether times are good (lots of food = time to breed and grow) or bad (not much food = time to repair and wait it out). Specifically (pp 100-101) 

There's a lot of methionine in beef, lamb, poultry, pork, and eggs, whereas plant proteins, in general, tend to contain low levels of that minor acid - enough to keep the lights on, as it were, but not enough to let biological complacency set in. 

The same is true for arginine and the three branched-chain amino acids, leucine, isoleucine, and valine, all of which can activate mTOR. Low levels of these amino acids correlate with increased lifespan ...

Now of course research is always evolving and it's difficult to know the right approach in the early days. However, FWIW personally I started my age reversal program in the 80's and back then all we suspected was "eat plants and exercise" - based on the early data we had back then (I've been a vegan since and have documented my biological age and measurements around the forum). Now we know much more, including the mechanisms by which animal foods, via specific amino acids, turn off the rejuvenation processes. Personally I'm scratching the amino acids off the list

*

When we substitute animal protein with more plant protein, studies have shown, all-cause mortality falls significantly

PS - great points Sandra - yes I have a number of other additions not mentioned including a multi

Jennifer Klein muscles don’t build simply from eating aminos. Search for Frank Medrano for an example of what you can do on a vegan diet (low aminos). Testosterone builds muscles with lifting and is the only way we know how to AFAIK

https://m.youtube.com/watch?v=RFPsvF3UOdo

Dan There is always a tradeoff with aging. In the case of amino acids, the trade off boils down to the mTOR pathway. Clearly AA's activate the pathway, which is the opposite of anti-aging. However, the direct negative outcome is sarcopenia and increased fragility. Personally, I use only the BCAA's and none of the other amino acids in an attempt to not lose muscle mass ( I'm a rock climber and I need it!). At the same time, I take metformin, which is a partial mTOR inhibitor. 

Jennifer Klein 

Yeah it's tricky! And I'm certainly not an expert in this topic. However women certainly do have testosterone, just not as much as men obviously. But having a little is important for your health and well being. Just as having a little estrogen gives men benefits too and is important. At any rate the topic is also near and dear to my heart as my wife is at an age where she is feeling like she is slowly losing muscle mass. FWIW we're working on her hormones, including testosterone, and exercise, both of which appear to help. I'll look more deeply into branch chain amino's also. 

sandra kaufmann 

Hello Dr Kaufmann!

When it comes to fighting sarcopenia I wonder if you have given creatine a thought as a substance with for being a potential substitute for leucine and HMB. (And with possibly less mTOR activation).

It is a well-studied substance and besides showing potential for addressing issues with sarcopenia the safety profile is quite appealing. And it has a long track record of being used in high doses by athletes during long periods of time with few or none side effects. At the beginning of its hype it was mostly used for exercise performance and muscle strength but now geriatric research is focusing on the ability of creatine to inhibit or slow down neurodegeneration, to reduce lipofuscin accumulation, to strengthening the heart (addressing congested heart failure) and for blood sugar control. Quite a lot of research has been done on rats and mice. But the evidence is mounting when it comes to its usefulness for increasing energy, strength as well as being a neuroprotector and heart protector.

I am considering of adding creatine as a more permanent substance. So far I have used it a for 3-4 weeks a couple of times a year. Now I consider reversing this cycle and to use creatine more permanently but with 3-4 of weeks off a couple of times a year.

Right now I have started a period of being “on” creatine and it gives me very nice feelgood effect with heightened energy and increased strength.

Dan Whereas getting rid of all of the free radicals is not a great idea, as they do serve a useful purpose, evidence is very clear that as we age, our own endogenous systems fails and we suffer from the consequences of free radicals. It is also important to note that we age for many reasons (ie 7 categories) and this is just part of one. 

Ira GoodmanIra MD I appreciate the vote of confidence! I tried to make this a very consideration and reasonable approach. There will always be outliers, but I have tried to make it as user friendly and scientific as possible. 

You can either get the NAD from NR or NMN- I really don't think it makes a difference. The best astaxanthin I believe is bioastin; its from an algae in Hawaii. Meanwhile, I don't think it matters on the Carnosine as it is a basic dipeptide.  

Mike Almerjanski I think that is the most beautiful thing I have ever seen!!!!

Mike Almerjanski Hi Mike, would you mind sharing this spreadsheet? You can email me at anar@qalytude.com

Thank you, Anar

Anar Isman will you notify when this is available?

Kelly Parmenter-Eck Hi it is available our service is functional. Please check out qalytude.com

Edward Sutherland Thanks for asking! In addition to the Panacea, Metformin can be started any time. I was hesitant to tell folks to take it, as it was hard to get from most primary care physicians. That is now a non-issue with the help of Qalytude. The NAD patch can replace the NR or NMN; it doesn't really matter how one elects to replenish their NAD.  In terms of Rapamycin, I'm not a big fan. I believe there are some questionable side effects, so I am hesitant to recommend that for anyone. (you will hear many conflicting reports and opinions on this!) 

Hope this helps-

sandra kaufmann sandra kaufmann 

Hi,

I'm going to start with the Kaufmann protocol, and have some questions regarding the supplements. I'm going to start of with Dr. Kaufmann's most recommended;

The most effective:
Pterostilbene
Astaxanthin
Nicotinamide Riboside
Curcumin
Carnosine

My question about these is;

When du you recommend taking these during the day?
On a empty og full stomache?
Pre or post workouts?

Do you have other supplements recommended?

Som added information, i'm 28 years old, very active in regards to workouts, eat quite healthy, no record of sickness, might have some inflammation and irritable gut.

Roger Did you email me separately? This sounds really familiar! If not, I'm happy to answer here.

sandra kaufmann hi,

Yeah, tnx for the reply.

Jennifer Klein Thank you, for the information.

David Hanson The only other thing to do for someone with severe osteopenia is to select an osteoblastic activator or two. Naringenin is probably the best known with the fewest side effects. 

sandra kaufmann I found gu sui bu in a Traditional Chinese Medicine shop in Kuala Lumpur a week after your reply. We also mix astragalus root (huang qu) and Japanese knotweed root (he shou wu) with it. And then cook all three in pot for decoction. We can’t find powders or extracts here, just the whole herb.

David Hanson That is truly fantastic! I think the Chinese have a bit of an advantage in all of this with their long history of medicine and longevity!

David Hanson said:
My wife and I are in Thailand and Malaysia for a few more months so I can't buy most of these until we return to the USA. 

 David Hanson -

I'm Bangkok.  Perhaps I can offer some suggestions.  I'll make these general to benefit anyone in this corner of the world.  If you want to discuss details, we can use private messages or talk by phone.

1. Amazon and iHerb deliver quickly.  Pay a little more for extra-fast shipping. 5-10 days.  But be careful of customs: anything over US$ 40.00 will be subject to duty and maybe to government inspection -- an aggravating waste of time.  Try to keep import orders under US$ 40.00 value per shipment.

2. A website in Thailand -- Lazada.com -- will have some popular USA brands like NOW, Kirkland, and Doctor's Best in stock here in Thailand. Delivery 2-3 days. If you are near the dealer, delivery in 1-2 hours. Thais are slow on many things, but on deliveries they can be very fast.

3. A few chemical companies here may have some Kaufmann protocol items.  If they do, then over-the-counter -- easy.  But they won't understand your English.  Best to show them a screen printout with names and chemical formulas of what you want.

4. For buying items like these, pharmacies here are a waste of time.  And if they don't have what you want, they will try to sell you what they do have.  And they will lie about what is in it.  Best to avoid pharmacies.

Questions welcome.

Mike Almerjanski 

Roger You might want to look at Dr. Kaufmann's Kaufmann Protocol website. She lists which ones should be taken with food and which ones should be taken with an empty stomach. I assume for the rest it doesn't matter. She also gives suggested dosing. If you pay the fees (monthly, semi-annual or annual) for her phone app, the app will make specific recommendations which would fit you better (you answer some questions in the app). For dosing website see: https://www.kaufmannprotocol.com/dosage

David Hanson thanks for the update. I might thought pre/post workout dosing had an influnce, will look more in to it.

David H  Surely one does not take ALL of those compounds on Kaufmann's website?   I admit I'm coming here from the RAAD event last week so am years behind you guys.  Probably would benefit from a "start here" for anti aging nutricals in the genra of spermidine/fisetine et al..   :)  tnx to all.

Curtis Smith No, you needn't take all of the supplements on Dr. Kaufmann's list.  It probably would be best to buy or borrow her book so you could understand her protocol.  However, you can get part way there by using her website:

1. Read https://www.kaufmannprotocol.com/fundamentals

2. Read https://www.kaufmannprotocol.com/the-kaufmann-rating-system

3. Read https://www.kaufmannprotocol.com/choosingyour-protocol

4. Read https://www.kaufmannprotocol.com/doses-links-2

5. https://www.kaufmannprotocol.com/doses-links-2

If you read these then you will have a basic understanding of her protocol.  If you read the book, you will understand much more including more information the actions of the recommended supplements.

I take maybe 2/3 of her recommended supplements.  You could cover her aging tenets with less. 

Also, consider watching this video and you can listen to her describing her protocol. https://www.youtube.com/watch?v=QJEheDeR8IQ

David H 

I am actually working on a list of agents for book 2. Spermidine is on the list- let me know if there are any other agents you want examined!

David H  Can you mention spermidine sources you'd recommend, IE who you buy frrom for your personal experiments?  Is there a cost / dose logic possible like there is for fisetine where some source for spermidine maybe cheaper but less concentrated bu take more??   tnx

Curtis Smith I am aware of three sources of spermidine for consumers in the USA.  I have tried two of them and have the third in our fridge which we will take when we finish the others.

1. The first one that I found was from LZRLabs: https://lzrlabs.net/order-37061865

LZRLabs is located in South Carolina - if you buy in quantity their spermidine has the lowest cost.  Instructions are to take 1 capsule per day.

2. The second one we have tried is: https://spermidinelife.us/

They are located in California but the manufacturing process is in Austria. (All three of them use natural spermidine from wheat germ.). This one is the most expensive of the three.  You take 2 capsules per day.

3. The most recent one that we have is: https://www.primeadine.com/

They named their product primeadine, I suspect because the name spermidine (which is the name given to the active ingredient which was originally discovered in human semen but later found to be in all the cells in our bodies) is controversial and even repugnant to some consumers.  They don't hide the fact that primeadine is spermidine.  As for me, I have heard a few dozen research papers on spermidine and the name doesn't bother me nor my wife.  (It seems to bother women more than men is my observation from reading posts online.)

Primeadine is more expensive than LZRLabs' spermidine but less than SpermidineLife's spermidine.  You take 3 capsules of Primeadine each day.  (The amount of Spermidine in the 2nd and Primeadine I believe is the same.)

We plan to use Primeadine mostly because I trust the founder of the company.  I have been on a zoom session with her and have corresponded with her by email quite a few times already.  Oxford University scientists are also involved with the company.

Instagram: https://www.instagram.com/primeadine/

Facebook: https://www.facebook.com/primeadine/

Youtube: https://www.youtube.com/watch?v=dluDCZg87OA

The founder has had her own health problems and she is very concerned and knowledgeable about health.  I have no financial arrangement with her or anyone else selling spermidine.

I do believe that everyone should be taking spermidine.   My wife and I bought a 6 months supply of Primeadine for our adult son who recently suffered a concussion during an automobile accident.

Finally, we take our spermidine with our evening meal.  It seems to us that it much improves our sleep quality after we changed to take it in the evening.

David H and to all,

Thanks for that great getting started post above!!! Tnx

Might folks comment on their efficacy / value of their spermidine sources?

Other forums discuss fisetin sources and varying efficacy as well.   One here buys from alibaba / China which may have product variability (or not).  Tnx

Jennifer Klein I love rhodiola- there will be a chapter on it in the next bnook I can currently working on

David H I find that spermidine makes me sleepy and that it improvs my sleep. So I take it with my evening meal. 

Staffan Olsson One of our sons and his wife found that spermidine taken in the evening greatly aids their sleep.

David H This is very interesting.  Seeing from the Primeadine Facebook page that spermidine is a prime ingredient in soybeans, why not just make them a regular part of the diet as the Japanese do?  Certainly a lot less expensive.  

Dorian Gray Leslie Kenny the owner of Oxford Health, the company that sells Primeadine, recently mentioned in a podcast that if you eat natto, you don't need Primeadine.  Her comment led me to researching the amount of spermidine in natto.  I eat 150gm of homemade natto daily and my wife eats 200gm daily.  I believe the amount of spermidine in this amount of natto is 20mg or more while the spermidine supplements have 1mg per daily serving.  So when our Primeadine supply is gone, we won't buy it again. If my memory is correct, and I don't know the reason, tofu has little or no spermidine.  Soybeans themselves have more spermidine themselves than natto by weight.  We will stick with natto for two reasons - 1. Unfermented cooked soybeans causes us to have intestinal distress 2. There are multiple nutritional advantageous changes to soybeans when they are fermented and become natto.

The problem with natto for the general public is that most western people don't like the taste and texture of natto. My wife and I are willing to eat any nutritious vegan food so we don't care about the taste.  We have been eating it for one and 1/2 years and we both like it.  We do think that homemade natto tastes better than store bought previously frozen natto (which is mostly available in the USA).

My wife's family is Chinese and I have convinced one of her sisters to try natto.  I explained that it would very difficult to find a food that is better than your health than natto.  Japanese children start eating it early, less than one year old per YouTube videos.

You are right, natto is much less expensive.  We pay about about $40 for a 20 lb bag of small soybeans (small is best for natto).  We buy it direct from a North Dakota soybean farmer who has told us that she doesn't use chemical sprays on the soybeans and the soybeans are not GMO.

David H Great that you and your wife don't mind putting in a bit of effort and thinking to achieve such a positive thing. It's a rare thing today in the age of "packaged" everything. While I don't eat it on a daily basis, I do consume it frequently. My wife is Japanese so we have been eating the healthy aspects of that culture for forty years now. We have Japanese markets close by so it is easy for us a lot of the things that aren't in regular stores. For natto, we usually get this brand: https://www.meguminatto.com Although she has made it herself often as well as Kimchi which we have regularly also.

sandra kaufmann On the page from https://kaufmannprotocol.com/a-note-from-sandy you mentioned that your vision improved. I have read about astaxanthin and carnosine, but I'm interested in what you did if you don't mind telling me more. Thanks.

Jay Orman In addition to the astaxanthin and oral carnosine, I use visomitin (SKQ1) eye drops and NAC eye drops daily. I'm sure the other 50 agents are probably helping a bit as well! 

sandra kaufmann I am now investigating SKQ1. It may be a viable option. My experience with Can-C for about a year is negative for what my opthalmologist calls a baby cataract in one eye. I researched Can-C (N-alpha-acetylcarnosine eye drops) thoroughly with pubmed documents before trying it and afterward. This simple article seems to sum up my thoughts of Can-C at this time : https://www.eyenews.uk.com/education/the-truth-behind-the-headlines/post/the-truth-behind-the-headlines-aprmay-2018 . The SKQ1 route looks interesting.

Jay Orman My wife and I have been using a 4% NAC product from the UK for the last 16 months.  I haven't seen an ophthalmologist nor optometrist during that time.  But my cataracts were worsening my vision so that I needed a new prescription every six months for the year before I started with the NAC.  My vision, as far as I can tell, has not changed during the last 15 months.

https://costcuttersrus.com/products/cataract-clear-nac-xtramax-eye-drops-2x10ml-highly-effective-for-people-dogs

That's the link for them - but I have been ordering it on ebay.

David H Do you have time to explain your process for making homemade natto?

Michael Fantastic!!!!

Curtis Smith I found the easiest way to get it over with - in three gulps - is to make an avocado banana yogurt smoothie (to which I also add my Collagen). Might shoot absorption to hell but literally, three piles of pills along with three smoothie gulps; done.

Michael I'm envious!!!!  I have a tolerable form of hietal hernia, which prevents easily swallowing even one pill.  I have to open or grind into a smoothie every pill.  The personal blender is both convenient and effective for my mountain of morning and evening nutricals.   The tribest blender is good little work horse.  Just $70 per base and holders.  I go through one every year or 2.  I have at least one on the shelf as backup since I'm dead in the water without one.  Take care with your gulps!   :) :)

Curtis Smith LOL Thank you, my brother. Last week I DID ask Dr. Kaufmann about removing the contents from those in capsule form to add directly to a smoothie and she was kind enough to email back saying "There is no reason you cannot put the agents in a smoothie, but some of them taste terrible and you might not enjoy it. As well, you can only do the ones that are water soluble." So, I paid my Daughter to empty the contents of every bottle into sixty individual baggies. My morning routine consists of digesting a bag with a smoothie in 3 gulps and hitting the treadmill for two hours.

Michael Excellent use of your children!!!  well done!

sandra kaufmann 

lol

I still need to get back in touch with you for consulting.

As an aside, I was considering Viome.  Any experience with them?