Combination of rapamycin, rifampicin and allantoin in fruit flies
A commercial product is being marketed with the following talking points.
https://novoslabs.com/why-combinations-of-longevity-drugs-are-the-future/
- In one study, three longevity drugs were examined to see if they could extend lifespan in fruit flies. These drugs were lithium (a mood-stabilizing drug), trametinib (a MEK inhibiting anti-cancer drug) and rapamycin (a mTOR inhibitor).
- Each substance in itself extended lifespan by about 11 percent. Combining two drugs extended lifespan by about 30 percent. Combining all three drugs prolonged lifespan by 48 percent compared to the untreated fruit flies (R).
- Another study looked into combinations of rifampicin (an antibiotic), rapamycin (an mTOR inhibitor), psora – 4 (a potassium channel blocker), metformin (an antidiabetic drug) and allantoin (an uric acid metabolite) in the little worm C elegans.
- A combination of rapamycin, rifampicin and allantoin resulted in an impressive 89 percent lifespan extension. A combination of psora-4, rifampicin and allantoin even resulted in a 96 percent lifespan extension, far more than each ingredient separately
Study was on fruit flies. No study yet on mice. The original study is found below:
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Although rapamycin and rifampicin are mentioned, the product is made of natural ingredients - AKG, fisetin, etc. That is the basis of the points below.
- Another study compared various ingredients like resveratrol and plant extracts to see if they could extend lifespan in yeast cells.
- The plant extracts were made from valerian root, Passiflora incarnata, ginkgo biloba, Salix alba, Apium graveolens, and Cimifuga racemosa.
- Using valerian extract or Cimicifuga racemosa extract alone each extended yeast lifespan by about 5 days, while a combination of the two extracts extended lifespan by about 12 days.
- Interestingly, resveratrol alone only had a relatively small effect on lifespan (achieving an increase of about 3 days), compared to Salix alba alone which increased lifespan by about 10 days.
- However, a combination of resveratrol with Salix alba increased lifespan by no less than 20 days, a considerable synergistic effect
The basis for the formulation seems to be the study below:
https://www.oncotarget.com/article/26553/text/
Another source of the same study:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349451/pdf/oncotarget-10-313.pdf
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I’m beginning to think that almost anything will extend the life of a fruit fly 10-15%. I’ve started ignoring studies with that result.
