I've just begun a 10 week self-experimentation with RapaPro rapamycin. I'll be taking 5 mg once a week, which is roughly the dose that Dr. Alan Green recommends on the high side and seems to be about what Dr. Attia supports/recommends.
I'm a 48-year-old male in generally excellent health. I've been following longevity science for a decade now and in the last couple of years have gotten more serious about it and also in trying new things that seem to have good data to back them up. I've been taking NR for a couple of years, as well as resveratrol and phosphatidyl choline.
After my first dose a couple of days ago I had some mild body euphoria that seemed to result from reduced inflammation. I felt less creaky overall and hummed with pleasure. I'm not measuring any biomarkers quantitatively, but will report my results in terms of reduced cold symptoms (I've had a mild sniffle for months now due, I think, to an ongoing tooth infection and the fact that I work out pretty hard a few times a week, leaving less bodily resources to kick my sniffles), increased/decreased energy, feeling of wellbeing, etc.
Dr. Green convinced me that there is real potential here when he talks about going from feeling very old at 70, unable to even walk his dog without suffering, to biking 40 miles and feeling great after.
I'd be curious to hear others' experience with rapamycin or comments on my dosing and schedule.
This blog is a little long – sorry. Almost all self experimenters are motivated and generally in good health. Benefits of low dose intermittent rapamycin may not be obvious. I have some insights which may be food for thought. I have practiced interventional pain management for nearly 30 years and an early adopter of rapamycin and metformin for personal age reversal – doing great. I have prescribed rapamycin to about 50 chronic pain patients representing the exact opposite of a typical self experimenter in terms of health. Instead, these very damaged human beings have severe diseases and injuries, often on opioid analgesics, many having implantable devices, and generally doing poorly. They cannot exercise and are far from optimal health or weight.
My observations suggest a variety of interesting rapamycin affects on these human beings. Pain reductions are quite notable for peripheral neuropathy, migraine headaches and other craniofacial pain (i.e. post traumatic headaches, trigeminal neuralgia, post craniotomy pain).
Psychiatric effects seem consistent and potent. At least 1/3 of this cohort experiences anti depression, anti anxiety, increased motivation and mild euphoria. These effects appear durable and lasting.
Certain diseases and conditions are notable for improvements in the underlying issues. Rheumatoid arthritis and inflammatory bowel disease seem to improve even prompting other specialists to remove disease modifying agents such as tumor necrosis factor agents etc. Multiple sclerosis seem to improve in terms of pain and neurologic symptoms. Traumatic brain injured have experienced cognitive and affective improvements.
Almost all these people are 55 and older. One much younger professional with lifelong affliction of severe anxiety and ADHD (both requiring treatment) had a remarkable improvement in these disorders unrelated to the pain condition and consistent with psychiatric effects mentioned above and no longer requiring ADHD or anxiety treatment by taking only rapamycin .05mg/kg/week.
Effects are also dose dependent. Purposely cycling patients between the higher dose levels of around 0.1mg/kg/week to the lower levels of 0.05mg/kg/week show better pain reduction and other described effects at the higher dose. Cycling is done to help understand the effects better and because I’m a believer that too much of a good thing may be bad. Patients are cycled for 3 straight weeks on higher level then 3 weeks on lower. I do the same for myself.
It appears that judicious use of mtor inhibitors such as rapamycin could be used as adjunctive therapy for a variety of diseases. It is a shame that such is not likely to be the case for many years. I think that people who are otherwise healthy and motivated are likely getting significant benefit from rapamycin. It's just not as obvious.
My first set of blood tests since starting Rapamycin in late November / early December. Additionally, I completed one Dasatanib/Quecertin 3 day protocol in January. My diet has changed from primarily plant-based to low-carb ketogenic which may explain some of the cholesterol changes.
Do y’all see anything I should be concerned with?
It looks like my insulin sensitivity has dramatically improved on the positive side. On the cholesterol side my triglycerides are significantly better offset by the increase in LDL-C.
In thee"Rapamycin for longevity: opinion article" by Mikhail V. Blagosklonny (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/) is stated: "The beneficial effects of rapamycin and CR may be additive, given that they are exerted through overlapping but distinct mechanisms. Intermittent rapamycin and CR (24-48 hours after) can be combined, to avoid potential hyperglycemia. Physical exercise may be most beneficial starting immediately after rapamycin use, to take advantage of rapamycin-induced lipolysis as a fuel for the muscles." Has anyone tried this approach?
I think a reply will require a source for the 14% . Perhaps 14% is the amount he should have given what dose he takes. I personally have been taking 3mg sirolimus per week with Grape fruit juice (white) which equates to about 10mg/week and am age 66 and get 60 to 70% relief from arthritis if my hands.... Which has allowed me to titrate the dose properly in collaboration with Dr Green for the past 3 years. Plus one year on Pfizer's Rapamune previously. I've also occasionally done D+Q but with Fisitein not Q. I think this is more about delaying or perhaps preventing chronic diseases of aging as I've recently been diagnosed with a non aggressive prostate cancer. I mean to outlive the diseases that destroy what otherwise might be early retirement. Lost two uncle's within 2 years of retiring at 65..... Their wives left alone but well funded. I think as you try to properly dose Rapamune/sirolimus you should concomitantly drastically reduce A.G.E. foods or CR and Rapamycin are useless. Best of luck but search The Smithsonian magazine to see how Grapefruit juice is used with Rapamycin to reduce the overall it's dose but keep cmax levels where needed.... Although this was at very high doses for cancer therapy the principal is the same. Don't use the more easily found Ruby Red GF juice, use white for best effect and mind you don't overdose on your other meds due to the GF Juice!