My Rapamycin Experiment: Male / Early 30s / Non-US Based

Hi,

So I'm currently at the early stages of experimenting with Rapamycin, and thought, if I'm going to take an experimental drug, I might as well document the process and see if it can benefit the collective.

As far as I know there aren't currently a lot of 30 year olds taking Rapamycin.

So, let's run through some info about me and what I'm doing:

How I came across Rapa, and why I'm interested to try it:

  • I was put onto mTOR / rapamycin / hyperfunction theory via Peter Attia and his podcasts/interviews, where he mentioned Mikhail Blagosklonny's research.
  • I started reading through Blagosklonny's work + animal studies, and the hyperfunction theory seemed to make a lot of sense.
  • Despite having an athletic build, circa 10% bodyfat, and being generally "healthy", I feel like I've been aging way quicker than I'd like the last 5 years or so.
  • An additional motivation is the early onset of age related diseases (particularly cardiovascular disease and cognitive decline) in my close family. Hopefully I can delay them longer than they have.

What do I expect to achieve with Rapamycin?

  • It seems possible that rapamycin will delay ageing, and thus age related morbidities such as cardiovascular disease (heart attacks and strokes), cancer and Alzheimers. How much will it delay them? It’s unclear.

What I don't expect:

  • Biological age reversal - we will need other drugs for that unfortunately.
  • To start looking better than I do now
  • To feel significantly different from how I feel without taking the rapamycin

Trying to find a doctor to work with:

  • Given how new rapamycin is in the context of longevity, I was keen to work with a doctor, to minimize risk.
  • As I'm not based in the US, it wasn't obvious how I'd go about working with a doctor and getting a prescription.
  • I initially looked at working with Dr Alan Green (rapamycintherapy.com), but he seemed to have a rule about only consulting in person, and with older people.
  • Then I started down the route of trying to work via telemedicine with US doctors who are prescribing rapamycin for longevity.
  • I found a doctor and arranged a call. Unfortunately I was let down by the experience, and realized I had a potentially better understanding of possible side effects and biomarkers to monitor.
  • At this point I decided to "go it alone" - as I wasn't going to be able to collect the prescriptions easily from the USA, and I wasn't overly impressed with the options.

Getting a baseline for biomarkers:

• For 2018 and 2019 I had done fairly comprehensive blood panels. So then in 2021 I did a further one to make sure I've got a good baseline for where I'm at.

• I specifically used the panel on this site - which is done via LifeExtension.

• This way I will be able to compare future blood results, and see if anything is vastly worse (or better!).

Buying Rapamcyin:

  • As I don't have a doctor to work with, this made getting prescription rapamycin impossible.
  • So I decided to go to the next best option I could find - Indian pharmacies.
  • I contacted a number of sellers on the India Mart website, and ordered some by brand Zydus. Who seem to be a relatively big Indian pharmacy.
  • They ended up costing about $1.70 per mg delivered.

Doses I've Taken So Far:

  • August 15 - 1mg
  • August 22 - 2mg (1 week apart)
  • August 29 - 2mg (1 week apart)
  • September 5 - 3mg (1 week apart)
  • September 17 - 4mg (12 days apart)
    (September 22 - blood donation)
  • Oct 2 - 4mg (15 days from last one)

Notes on dosing:

  • As you can see, I started off at the bottom of the dosing scale, and gradually increased.
  • At the 4mg mark I decided to move from 7 days to 12 days between doses, at least for now.
  • I had no side effects until dose 5, at which point I spotted my first mouth ulcer. I don't normally get mouth ulcers, so there's a good chance it's related to the rapamycin. It lasted about a week before healing.

Do I feel anything?

  • I don't think I notice any difference whilst on the rapamycin.
  • The only thing might be a slight increase in energy and interest in moving about - but that could just be placebo / natural - it's hard to tell!
  • On the plus side, I don't feel worse, and nothing has got worse physically that I'm aware of.

What I’ll do going forward?

  • Dose: I’m probably going to hover around 4 mg every 12 days, and get an idea for my tolerance at this level.
  • Measurements: I have waist measurements, so I’ll keep an eye on my weight. However, as I’m already at a healthy weight for my height, so I don’t expect things to change much.
  • At a future point I'll do another comprehensive blood panel and see if anything appears negatively affected.
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  • I’m 61 and started taking rapa four weeks ago. Have a friend who is a physician who is intrigued by it and I am his guinea pig. I am taking 6 mg each week. First week I had a weird acne sore about the size of a dime near my lips. No other side effects since then except I have trouble sleeping until the 3 day male half life is done. Going to have some blood work done after four weeks per his requirement. Paid $308 for 30 two mg Sirolimus tabs at local pharm…A 10 weeks supply at my current dosage

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    • Walt Fair - Sounds good Walt! Nice to have a friend (physician) keeping an eye on your progress with you.

      Sounds frustrating about the sleep disruption, but perhaps that'll change as time goes on.

      Keep me posted on how you get on!

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  • Redo the experiment when you're in your mid fifties. Doing it at your age is like watching a YouTube video on wrinkle reduction, created by a 23 year old model. No offense. And the blood panel isn't going to demonstrate jack shit.

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      • Walt Fair
      • Walt_Fair
      • 1 yr ago
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      Michael 

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      • Walt Fair
      • Walt_Fair
      • 1 yr ago
      • Reported - view

      Michael, you are correct that the four week blood profile showed no changes. No surprises there but it gave my conservative physician buddy the desired comfort level regarding an off-label use of an immune sytem modulator that will enable my continuing use of a compound that you apparently believe only adds value to the pre-Boomer crowd. Up your dosage. No offense.

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    • Michael - I think I'll pass on that well researched, evidence based "advice". But thanks for the input, I'm glad you could help out.

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      • Walt Fair
      • Walt_Fair
      • 1 yr ago
      • Reported - view

      rapa_experimenter An interesting sidenote…I was born with a heart murmur and had to have a valve replacement when I was 49. Went in for my annual check up with my cardio guy and they always ask you what medications you’re taking. I told him about my 6 mg rapa per week not expecting him to know anything about it and he replied “Good move!”; he’s early 50’s and has been taking 4 mg per week for several months along with several other physicians in his office and they all think it is the real deal.

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    • Walt Fair - Ha! I would never have expected that! Thanks for sharing that.

      There is one connection with the cardiovascular system and rapamycin that comes to mind. Which are "dug-eluting stents". So the stents are inserted into arteries to keep them open, and then some of these gradually "elute" (release) rapamycin in order to block cell proliferation.

      That's cool that these guys are both interested and enthusiastic about the rapa.

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