Hard to say what the optimal dose is or the optimal interval since we are basically making this up as we go along. Dr Alan Green however, recommends taking all 3 on a quarterly basis if you are healthy. If you have health issues he recommends closer dosing intervals such as every month or two. I am "healthy" and take that combo about every 6-8 weeks. I will start my 3rd dose tomorrow. After that I will probably go to a quarterly dose schedule unless more research shows up to dictate otherwise.