I have said before that I think including calendar age as a parameter in an estimate of phenotypic age is, in a way, cheating. However, that's what Levine & Co did, so to replicate their calculations that's what I had to do. The inclusion of calendar age insures that the phenotypic age is never very different from calendar age.
Curtis Smith more accurate? You want accuracy but low cost? There are other epigenetic clocks but Horvath is deemed the most accurate in humans. You should stick to one clock if you are going to establish a baseline and then assess the impact of changes. One thing I didn’t know was that exercise can actually increase DNAge, although it is a lifespan extender. Turns it the sites that are impacted are actually considered pro lifespan, even though they may methylate on the Horvath clock.
Curtis Smith Yeah I agree given the importance of attaching true anti-aging significance to relatively potentially very expensive, time consuming, and often significantly lifestyle infringing interventions. I did the blood version, although they also have urine. Blood was more whole body scanning.