Rapamycin - progress so far
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Hi all,
About me: I'm 46 y.o. medical doctor based in Europe and started taking weekly rapamycin 4 months ago. I go to the gym regularly and am in average physical condition for a guy of my age. The last couple of years have brought the first negative signs of physical aging: aches and pains that don't go away, increasing belly fat, a decline in gym performance, wrinkles and increased pigmentation, grey hairs as well as slower wound healing. Am venturing on this rapamycin journey to see whether it can slow down the inevitable age-related decline and see how it impacts my aging longer term.
Where I'm at now: I started rapamycin 4 months ago at 2mg once weekly and have been slowly increasing the weekly dose by 1mg each month. Now at 5mg per week. I intend to continue on this dose increase scheme until I reach the highest optimal dose, beyond which side effects become an issue.
Currently have experienced zero side effects, not even mouth ulcers. I have noticed improvements already in body composition (slight reduction in body fat) starting at the 3mg/week dose and most recently increased gym performance (cardio vascular and muscle strength increase) since being on 5 mg/week.
Intend to progress to 6mg/week in September.
Will at some stage probably try topical rapamycin on wrinkle / pigmentation problem areas as well. In Europe a rapamycin solution (Pfizer) is easily available in pharmacies.
Body pictures from today are attached.
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NEW ANTI-AGEING FORMULA FROM DR. BLAGOSKLONNY
TWITTER SEPT. 25TH. 20214/5
Rapamycin high dose intermittently
Low-Carb or Low Carb/Cal diets, time-restricted, IF
Physical exercise daily
Sun, Sunbath/Vit D3
Metformin low/medium dose
Angiotensin II inhibitors
Aspirin low dose
Lithium low dose
DHEA, L-Ornithine
NAD boosters
PDE5 inhibitor5/5 Other agents to consider:
Alpha-estradiol for men when become clinically available
Acarbose (if cannot adhere to Low carb diet)
Fisetin
Doxycyclin (once/twice a month)
And other compounds depending on conditions
Goes on to say evidence on NAD boosters, and Fistein is weak, but will not hurt you except for pocketbookHe also states, "These recommendations are for medical doctors to consider for there patients." He does not make recommendations directly to people because not practicing medicine. That is why you will see no dosing recommendations, leaves that up to your doctor.
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Hi George, I was wondering if you’ve had any problems with skin infections (which would indicate a weakened innate immune system). I’m 59 y/o and have been taking 6mg/week over past 9 months and gotten 2 infections that seemed to proceed quite quickly. Treated both with antibiotics successfully, but am concerned that I’m weakening my immune system too much (too much MTOR inhibition?). I’m going to start taking 6mg every 2 weeks to allow the rapa to fully exit my system. Also seems logical that we should fully alternate between low MTOR and normal MTOR levels.
What might also be complicating my situation is that I take other things that reduce MTOR (eg metformin, curcumin extract, etc). I’m not diabetic, but take the above for life extension purposes.
Any thoughts given your experience?
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Anyone here dealing with skin rashes from rapamycin? I get skin rashes from just 2 mg weekly, about every second time or so. If untreated they get unbearable; with anti-inflammatory cream the rashes are quickly subdued. Either I will be hyper-vigilant just needing a small amount of anti-inflammatory as soon as the first itching starts, or just take the 2 mg every 10 days or so. Seems no way I can do the high doses mentioned on this thread. Maybe try 4 mg every two weeks...... trying to find my way.
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I take 15 mg of rapamycin every two weeks.
Recently had epigenetic age measured by TruDiagnostic. Was about 9 years younger than chronological age which agreed with Levine calculator
One unexpected report was on what they called Extrinsic age which was described as bio age of immune system. For me the report showed a 19 year reduction in my immune system age.
No sign that rapa is having a negative effect on my immunity.
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Has anybody noticed or heard about a sharp drop in neutrophils after taking rapamycin? When I upped the dose to around 6mg bi-weekly (2 mg + fresh-squeezed citrus juice) my neutrophils dropped 50 %. No change in lymphocytes or red blood cells.
When I reduced to around 3mg bi-weekly, neutrophils only dropped slightly.
Will try papaya fruit extract to bump up my neutrophils. If this doesn't work it seems I have to stay far from the dose I would like.
There ain't no free lunch.....