Rapamycin - progress so far
About me: I'm 46 y.o. medical doctor based in Europe and started taking weekly rapamycin 4 months ago. I go to the gym regularly and am in average physical condition for a guy of my age. The last couple of years have brought the first negative signs of physical aging: aches and pains that don't go away, increasing belly fat, a decline in gym performance, wrinkles and increased pigmentation, grey hairs as well as slower wound healing. Am venturing on this rapamycin journey to see whether it can slow down the inevitable age-related decline and see how it impacts my aging longer term.
Where I'm at now: I started rapamycin 4 months ago at 2mg once weekly and have been slowly increasing the weekly dose by 1mg each month. Now at 5mg per week. I intend to continue on this dose increase scheme until I reach the highest optimal dose, beyond which side effects become an issue.
Currently have experienced zero side effects, not even mouth ulcers. I have noticed improvements already in body composition (slight reduction in body fat) starting at the 3mg/week dose and most recently increased gym performance (cardio vascular and muscle strength increase) since being on 5 mg/week.
Intend to progress to 6mg/week in September.
Will at some stage probably try topical rapamycin on wrinkle / pigmentation problem areas as well. In Europe a rapamycin solution (Pfizer) is easily available in pharmacies.
Body pictures from today are attached.
Thank you all for sharing, it's all very interesting, and I read your messges only now. I've had to stop after three months in 2020 because of the lack of the medicine. Apparently it's possible to obtain it in parts of Europe. If that holds true, that might change my perspective considerably. Best regards to all
Hi George, it's good that now quite a few doctors are in the network. It's a pity that the conference we were waiting for, an opportunity to physically meet in EU, hasn't taken place yet and all we have is zoom meetings - e.g. the HEALES meeting. I was the first to say we should have some physical meetup some time - just before COVID.. Longecity had them for years - when I wasn't even aware of these developments we talk about here. Until I read of the RAADfest of 2019. I've been away from the Forum for a while, just trying to find another country where to be able to use these medicines, while waiting for COVID to allow some travel. But having come back today I can see many good changes! I hope meeting becomes an option some time soon. I even spotted an Age Reversal doctor in Spain on the Age Rev. Doctors'list! Unfortunately on this site nothing is encrypted, not even the site's email (I left the social networks and I have only encrypted mail, Signal and Mastodon). I had seen dr.Green- that was to get started with the steps suggested as the first ones in the RAAD protocol of 2019. Only problem has been the EU, so I had to stop. Just sent a message to Peter, he says now it's possible to get Rapamycin in Europe - that would make things so much better. Still we can't be completeley on track with the testing to take part in the Netwrok's studies here. Thanks to you too for sharing your experience.
Besides reducing rapa dosage at the point you experience side effects, or adding days between doses there may be a third option to reach the maximum dosage without side effects.
Recall that Fahy showed in his TRIIM studies that growth hormone regenerates the thymus, which is pretty much gone by age 40. Most people don’t have access to growth hormone but if you did, what if you were to take a once a week dose of HGH? That is not enough to regenerate the thymus, which requires 3 doses per week, but it may be enough to retard thymus involution and have cumulative beneficial effects as well over time.
This is pure speculation, but I did discuss with Fahy, that since HGH is a TOR, if you take rapa on Sunday and HGH the following Saturday night, the small amount of rapa that is left in the system is effectively offset by HGH, thus dis-inhibiting TOR for a brief period until the next day's rapa dose. To the extent that is true, then you might be able to tolerate a larger dose of rapa. Anyway, I just started cycling sirolimus with growth hormone. I'll see how it goes. Maybe it will be beneficial. Maybe not.
Just read through last several months of Dr. Blagosklonny's Twitter tweets.
1. He wrote that it's best to take as much as you without side effects.
2. He showed a video of him taking 20mg Rapamycin. I didn't find the time between doses.
3. Someone else reported that they corresponded with Dr.Green by email and he written that he was taking 20mg every 2 weeks.(this is different than what he said in a more recent interview in which he said 12mg).
After reading this, I plan to to slowly increase my dose. I do eat a whole grapefruit 30 minutes before I take 7.5mg weekly.
I admit I was skeptical.about the higher doses. Thank you to the members who posted about the higher doses.
PS These are not my recommendations for anyone else. I suggest people should always do their own research. I always feel better about dosing when I read original documentation directly from the Rapamycin experts.
Not sure if you've done this already - but it's definitely worth (also) measuring your weight circumference. Which is the point just above your hip bones.
It fluctuates a bit based on time of day - certainly post meal it'll be wider. Morning, before eating or drinking much may be the best measurement to use.
You'll like notice a change on this measurement before you notice much change in the mirror.
It's something I'm doing personally anyhow.
So, it’s time for the monthly update.
I increased the weekly dose from 5 to 6 mg on the 1st September and still have had no identifiable adverse reactions. Nothing at all, not even a solitary mucosal ulcer..
Yes, this is subjective, but I do have the impression that I am already experiencing several benefits..
Firstly I have stopped putting on fat, regardless of how unhealthy my diet. I am also reasonably certain that abdominal fat and fat otherwise around my middle is becoming less. At the suggestion of a number of you I will start taking waist measurement and post these with future updates.
The most interesting improvement though is a definite improvement in cardiovascular performance. I am not out of breath as easily and exertive activities are noticeably more easily mastered. Example: treadmill. For years I’ve been doing a once weekly session of 50mins on the treadmill. For the last 5 years my top speed had a consistent ceiling of 8.0-8.5 km/hr. Within two weeks of starting the 5mg / week dose (6 weeks ago) I upped that to an average tempo of 9.0km/hr and on Friday, when I last trained, I averaged 9.2 km/hr. While these improvements are small, they are noticeable and prior to starting on this journey, unachievable. There is no plausible alternative explanation in my routine for this improvement.
All things going well I will increase to 7mg / weekly beginning of October. What I am most of all keen to see is whether there is any improvement in various inflammatory conditions that I deal with: skin, sacroiliac joint, prostate.. From a health and longevity perspective inflammation is the concerning point on my agenda and am curious as to whether there’ll be any impact at higher doses.
I will post photos again in November and then quarterly thereafter.
18.09.2021: 104 cm / 41 inches
I’ve spent a lot of time training, but even after lots of practice, I couldn’t see a pleasant result for me. I didn’t know what was the problem until I figure it out. The biggest problem for me was the unsuitable fitness machine. Especially I couldn’t understand why the calves were so hard to gain. Therefore I advised the gym to change the calf raise machine. They bought some from https://fitbodybuzz.com/best-calf-raise-machine-reviews/, and now, all customers are more than happy. Their equipment is high quality and perfect for gym exercises. Highly recommend them!
NEW ANTI-AGEING FORMULA FROM DR. BLAGOSKLONNY
TWITTER SEPT. 25TH. 2021
Rapamycin high dose intermittently
Low-Carb or Low Carb/Cal diets, time-restricted, IF
Physical exercise daily
Sun, Sunbath/Vit D3
Metformin low/medium dose
Angiotensin II inhibitors
Aspirin low dose
Lithium low dose
5/5 Other agents to consider:
Alpha-estradiol for men when become clinically available
Acarbose (if cannot adhere to Low carb diet)
Doxycyclin (once/twice a month)
And other compounds depending on conditions
Goes on to say evidence on NAD boosters, and Fistein is weak, but will not hurt you except for pocketbook
He also states, "These recommendations are for medical doctors to consider for there patients." He does not make recommendations directly to people because not practicing medicine. That is why you will see no dosing recommendations, leaves that up to your doctor.
Hi George, I was wondering if you’ve had any problems with skin infections (which would indicate a weakened innate immune system). I’m 59 y/o and have been taking 6mg/week over past 9 months and gotten 2 infections that seemed to proceed quite quickly. Treated both with antibiotics successfully, but am concerned that I’m weakening my immune system too much (too much MTOR inhibition?). I’m going to start taking 6mg every 2 weeks to allow the rapa to fully exit my system. Also seems logical that we should fully alternate between low MTOR and normal MTOR levels.
What might also be complicating my situation is that I take other things that reduce MTOR (eg metformin, curcumin extract, etc). I’m not diabetic, but take the above for life extension purposes.
Any thoughts given your experience?