Measuring biological age by the reaction of those around you
I've found a novel way to estimate biological age, which is the reaction of people in your circle to the changes in you.
In the past year I've
- Put in a home gym and now do Pilates and cycling daily (45 minutes)
- Gone on HRT
- Started Metformin
- NAD patches
- Refined the supplementation approach
What's interesting is to compare anecdotal experience of the changes
There seems to be a synergistic effect. Each thing I did had it's own small contribution - after taking Metformin I noticed feeling more 'in control' after a meal and less effected by it. With the increased exercise (and I'm a lifelong exerciser) there's likewise more wellbeing, with the HRT more energy and drive. Overall the sum of these changes seems to be greater than them individually.
Coworkers now are saying they keep forgetting I'm a dad because I have so much energy and act so young. My wife says I have the energy of a person 20 years younger suddenly. From the inside I don't have this perspective, to me it seemed more incremental and small changes.
Anyhow two points - one is the importance of doing everything you can. It seems that just one aging factor can make you feel and appear older. For example, even a young person with say a sports injury or a broken leg is probably feeling and appearing older than their biological age. Attacking cosmetic aging, cellular and macroscopic (e.g. muscle tone) are all worth doing.
Secondly is that perhaps one of the best measures of aging is how other people view you!
Comment by a fellow swimmer today rather made my day. I swim 4-5 days a week for 1.5 hours. The lanes are divided essentially by performance, from slow, lap at a time, up to rigorous structured workouts. I swim near the middle, doing continuous laps at varying speed.
After today's swim, a fellow I didn't know said "I swam with you, and you never stopped". He appeared about 40, while I'm 74.
Swimming is rather boring, and about the only diversion is watching other swimmers. I rate others on form, speed, endurance, rest stops, variety of strokes, age, and whatever seems unique about individuals.
When I switched from trail running to swimming a few years ago I ended up frequently swimming with a gal who did a mile a day, 4 days a week. I was maybe 90% of her speed and endurance, and we ended up talking a bit during rest stops. At that time, a mile was a long ways. I swam a few laps, and rested for several laps worth of time.
Today I swam just short of 2 miles, higher than my usual norm of 1.5 miles or so. I swim at a speed that I can do continuously. On a really slow day, I'll do a mile. On a strong day, I've gone just over 2 miles.
That gal who used to beat me at a mile still performs about the same. She's faster than me for the first half mile or so, but I usually catch up by a mile. Then she quits and I go on for another half mile or more. I asked her why she quit at a mile, and her reaction was that I was boasting. Maybe I was, but I really didn't understand why someone who was stronger than me would quit when I had plenty left.
The rather unique things that I do include low fat vegan diet, high vitamin D, cycloastragenol, proteolytic enzymes, and recently rapamycin / dasatinib / quercetin.
The dasatinib / quercetin seem particularly important in supporting endurance. Maybe a month after the D+Q was the first time I ever swam 2 miles, 2 days in a row. It's now something I can do every few weeks, where before I'd only done 2 miles a few times, let alone 2 back to back. It's not that I feel stronger, I just don't fade before the 1.5 hour session is up.
Thanks Dan. I think my power is about the same, but endurance has improved. I tend to exercise at a heart rate between 110 and 130, with 150 being the upper limit. 20 years ago I ran a 10k at an average heart rate of 180, and finished a half marathon at 199. Ticker doesn't go that fast any more...
My interest in the vegan diet started at about age 45 when my peers started having serious health problems. Dr. Caldwell Esselstyn wrote about curing severe cardiac problems with his vegan diet. Guys with two month death sentences ended up living at least another 20 years. Several dropped out because they'd rather die than eat like that. They got their wish. His curative diet is severe, but his patients were in dire straights. His son, Rip Esselstyn is better known for his Engine 2 books and food products. The principles are the same, but designed to maintain health, not bring it back from the edge. One rather unique aspect of their diets is the avoidance of all oils, including olive oil. Olives are OK, the extracted oil apparently damages the vascular system. Flavored vinegars can be used instead of olive oil for flavor.
I dug into my pill pile and found an almost empty bottle of creatine monohydrate. So I used it several years ago and lost interest. But the problems that it improves align with my current condition. I noticed that creatine down regulates myostatin, one of the causes of sarcopenia in older folk.
While the Esselstyn vegan diet supports vascular health, it does appear to be less than optimal in terms of maintaining muscle. Dr. Nick Delgado is a world class power lifter who advocates essentially the same diet. I don't think he uses creatine, but he does use quite a variety of supplements (that he sells).
I prefer "personal experience" instead of "anecdotal". And N=1 is perhaps the most important stage of knowledge. Without N=1, there would never be more advanced stages of knowledge. Consider the atomic bomb - was N=1 significant? Medical people would say no. No control group, no blinding, no measure of significance. Those atomic scientists just don't care about real science do they?
I just found this forum while searching for a rapamycin source in Canada. I take a lot of supplements including carnosine, benfotiamine, quercetin/tocotrienol combo (cycled), NAD+ sublingual, reishi, lion's mane, colloidal silver and astragalus. A dermatologist said he's "never seen skin like yours. It's more like that of a 35-year-old" and trying to convince BC Ferries that I am a senior, even with presenting my DL, has become less of a joke and more of a pain in the neck. iHeart regularly gives my "internal age" reading as between 50 and 56. So far, feeling like a 20-year-old, touch wood. I am 67 and a vegetarian, no eggs, cheese once a month and grass-fed milk in my tea.
Follow-up on apocynin. I have been AWOL due to a family issue. Back in the game and have just received my apocynin. I have to get some DMSO to dissolve it in, then put it in an aqua-free serum. Anyone else done this for skin rejuvenation? I see someone on Longecity tried it several ways but found it had no effect on wrinkles.
Hi all! Dorian Gray Well, after a ridiculous delay, I started my apocynin protocol four days ago. I have noticed that I am getting little lines above my upper lip. So that is my first hit, twice a day. I apply it all over my face once a day and once a day on the back of my hands, which are flawless in terms of discolouration, but the skin is very thin (and currently dry due to all this hand-washing).
I have no idea how long before assessing results. Anyone? I am using distilled water (4 oz) 20 mg of apo, 2 mg non-iodized salt, and 2 drops DMSO.
Off to read the COVID thread. Wishing everyone the best of health.
@dantheman Dan I haven't started the creatine yet (I am vegetarian). I take everything else and recently hit 15 years of daily carnosine use, including eye drops. I'm getting some creatine as I need to build muscle back. I used to train hard but now have sarcopenia due to laziness in that department. Re your RHR. That is good. Mine varies between 64 and 72. It is currently 64. I have a strange heart. If I stand up and simply walk around the house, it can shoot up to 92-115. When I powerwalk along the trails, it is 125, just 10 beats higher. I have had EKGs and all are OK.