Introduction to NAD+
NAD+ is an acronym for nicotinamide adenine dinucleotide (quite a mouthful). It is a cofactor in the body, used by multiple enzymes and processes, including energy production and DNA repair.
The amount of NAD+ in cells has been shown to decline with age in multiple organisms. Its involvement in DNA repair is particularly interesting, because DNA damage accumulates with age, and it appears that lower NAD+ in advanced age may not be enough to enable necessary DNA repair.
Fortunately, cellular NAD+ levels can be increased by simple oral supplementation with its precursors, though restoring NAD+ to youthful levels may require very large doses, or a different route of administration, such as intravenous.
I'm currently (May 2018) supplementing with 100 mg of an NAD+ precursor, nicotinamide riboside from Life Extension, twice per day.
Is anyone else supplementing with NAD+? Have you noticed any effects? I haven't noticed anything myself, but I'm relatively young (35), and plan to keep supplementing with it, while assuming it's likely doing me some good (and probably no harm).
I'm also interested in hearing the experiences of anyone who has tried intravenous NAD+, or is part of an NAD+ study. Some people have reported lower blood pressure, better sleep, and increased mental acuity.
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I have had another go at taking N+R to increase my NAD levels. Tried all the precussors without luck in previous years. A little background. I am almost 76 yo. 168 lbs, 71", good health, blood pressure and glucose under control, lift weights, and walk daily. Have low stamina and decreased energy. Nicotinamide and RIbose powder are my supplements. I know many studies have concluded that NAD precussors cannot get into the cell because of filteration by liver. I decided to do an experiment with N+R. I will take 1 gram of each daily (2 grams total) and see if the higher dose has an effect on my energy levels. I am pleased to say after 1 month, that I can lift more weight and walk further than previously. I believe that at this higher dose, enough of the precussor gets past the liver to the cell where NAD is produced. All these other NAD precussor companies (NR, NMN, etc.) were selling there products for a lot of money and very low dosages. If they sold higher doses, that would have been too expensive for most people.
This is a low cost way to experiment with yourself. So, if past 60 yo, why not see how you do. This along with Rapamycin are the 2 Holy Grails for ageing. Rapamycin extends life, but that is not enough without enough energy to enjoy the extra years.
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Van can you give a link to these supplements so there is absolutely no confusion?
second… have you tried high doses of flush Nician? I have read accounts that 2grams a day significantly boosts energy and longevity… likely through NAD. I saw an account of a women who started this in her 30s and was quite sharp and well in her 90s. Of course it can take up to 6 months to get the dose so high… as 100mg will cause a flush at the start.
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Arizona Kid Here is one link, but I live in Europe. You can find the Riboside, just look for it. https://www.amazon.com/BulkSupplements-Vitamin-Niacinamide-Powder-grams/dp/B00GW2LXWY
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Kaptain Asia Stand alone, but I had already done the Manipulating Mitocondria Dynamics for 4 weeks, but then did not improve more from there.
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Van Cheap d-ribose from NJ here.
https://shopbestnaturals.com/products/best-naturals-d-ribose-powder-1-lb?_pos=1&_sid=6d579a5f6&_ss=r
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Van I thought you said Nicotinamide? Is that the same? And then just powdered ribose?Van again why not nician?
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Arizona Kid Niacinamide or Nicotinamide is a form of vitamin B₃ found in food and used as a dietary supplement and medication. Much cheaper in powder form. N plus R is equivalent to NR.
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Van, that is an interesting technique. Please keep us posted. I used NMN for over two years at a dose of 1 gram daily, and NR before that. I don't know if it was the NMN or the coffee, but I thought I noticed an improvement in energy. I stopped when I began rapamycin so that I could be clear on what rapamycin does. If your technique works I may try it considering the cost of NMN. And, yes, the low doses most people take probably don't do much.
