Are these issues related to rapamycin

JGC A bit off topic, but...  I'm not taking Rapa, but several years ago I had an outbreak of shingles so later I decided to get the Shingrix vaccine.  I got the first shot, but the side effects were more extreme than with most vaccines so I wasn't going to get the second.  However, my doc persuaded me to get it, and I did.  

Recently, I saw an article that suggested that shingles could be an activating trigger for other viruses leading to increased possibility of developing Alzheimer's disease.  Apparently, the shingles vaccine correlates with a reduction in incidence of dementia as well.

Shingles infection may awaken dormant neurological herpes viruses, causing inflammation and accumulation of Alzheimer’s associated proteins in the brain.

<https://scitechdaily.com/common-viruses-may-be-triggering-alzheimers-disease/?fbclid=IwAR3lDZth0DkhPuAgTWv6YRRivmXQ47Fv61vk-idojSHcqMZIrXYrX5XlX6w>

JGC I have not

Dan Nave a few things.  I too had a bad reaction to my first shingles vaccine.  The second wasn’t as bad as I medicated with Tylenol and Ibuprofen for 24 hrs after the shot.

Shingles is a reactivated herpes virus. I have not heard of shingles or the vaccine activating other herpes infections.

Lastly, the the Alzheimer’s connection is doubtful.  And worse the whole Alzheimer’s due to amyloid protein is in doubt as the “big” first study that showed that connection was fraudulent.

Karl Either check out the link a few posts above or search the quotes provided there,  or see this link:

https://content.iospress.com/articles/journal-of-alzheimers-disease/jad220287

This seems to be new info, I can't vouch for it beyond what the article states.  It seems within the realm of possibility to me.

Dan Nave interesting, thanks.

Karl The Alz / Plaque research is discussed in depth with researcher input here: https://www.rapamycin.news/t/rapamycin-increases-alzheimers-associated-plaques-in-mice-study-finds/1787

JGC Very interesting. 

JGC Only 1mg a week? Why so low of a dose?
 

Karl Just to proffer a different opinion.  Only on Age a short time, but I've realized many are interested in life extension, but not holistic -- despite many being LEF readers.

Generally, IMO, all vaccines have substantial risks.  Yes, everything has risks, but whether shingles or other virus, my understanding is it never leaves the body, but is merely "controlled."  That is the function of the immune system, which has worked well for most of man's 400,000 year existence.

That AD is implicated in some whom received Shingles vaccine is not a surprise.  Although  many in holistic community have considered Alzheimer's Type III diabetes, and mostly a product of the typical High sugar, high carb, low fat (brain is about 60% fat,) generally crap diet.

My holistic MD for many years, says he was taught if you want to find a drug with few negative side effects, use a new drug.  Shingles vaccine for > 50 y.o rec'd FDA approval about 10 years ago.  Lawsuits have appeared just past few years, including possible blindness, etc.

I'm not trying to present a full case, as there is much info available, just to state an opinion opposing shingles, or most / all vaccines.

Michael_B didn’t realize you were an anti-vaxxer. Impossible to argue/discuss a religious belief system.

Karl For the record, I'm a devout atheist!  My "pedigree" is via Ayn Rand.  Regardless, despite your incorrect assumptions, your argument (sic) is one of the worse, most evil, logical fallacies -- i.e., ad hominem,

But you must be aware there are many medical / scientific questions about all vaccines, from childhood MMR vacs, to shingles, covid, etc.  And legitimate questions raised from autism, to other serious negative side effects, sometimes taking 20-30 years to impact our immune systems.

And BTW, I had the first 3 covid vacs -- which technically is not a vaccine in traditional sense -- but will not do any more, as the latest vacs have little effect on the new variants.

So others will not jump to your type of conclusions, I will add "Atheist" to my profile.

Michael_B my apologies. I did not assume you were religious, but strong belief systems surround vaccines these days.  My learned professional opinion is that vaccines are miracles of modern science. They have side effects which are rare and are strongly outweighed by the benefits.

There have never been any proven connections between vaccines and autism. Covid is a vaccine. There have never been any vaccine side effects that started years later. You may not be an anti Vader but you share their thoughts.

Karl You continue to place me in a group, I specifically said I am not a member of -- whether a religious group, or an anti-vaccer.

No point in our discussing more, but for those reading, there is fair amount of evidence connecting vaccines with autism, although IMO it was  at least partly due to the mercury added to almost all vaccines, until made illegal.

Or do you also think that "modern dentistry" placing mercury in mouths, is also a "miracle of modern science?"  Even today, in some U.S. states, if a florescent bulb   (mercury) is broken, the hazmat team is supposed to be called in.  Apparently the only safe place for mercury is in deep, contained storage, or in children's mouths -- or via Thimerosal  in vaccines.

But more impt, if you examine every vaccine, from Salk, etc., the respective disease declined well before the vaccine was in general use. 

And re covid, try telling the millions of long-haulers of the benefits vs risks.  And that has also been linked to some AD.

Michael_B well we agree that there’s no point discussing. I hope anyone reading your posts realizes you are putting out misinformation.

Michael_B I believe you have misread the information about Shingles and Alzheimer's Disease.  It is not the people who had the vaccine who had more AD, but the people who had Shingles... 

There was a reduction of AD and dementia in people vaccinated against Shingles.

Dan Nave Sorry, Dave, you are correct.  I almost forgot my posting,  but my point was re vaccines generally, AD, not merely the shingles vaccine.  And shingles seems clearly due to weak immune system, which is main reason the virus from childhood was contained, but after age 50-60, many have an immune system too weak to continue containing it. I have not investigated Shingrix, but just a few years may not be long enough to identify all the negatives.