Dasatinib update
Just finished a 3 day course of D & Q. The Dasatinib was purchased from Taylor Made Compounding. Dosage was 100 mg D &1000 mg Q. Cost for 6 @50 mg capsules, including shipping was USD $33.
Side effects were much more noticeable than when I took the Dasatinib that I purchased from BonHoa in India.
Headaches, nausea, and occasional vomiting.
Next course will probably be 50 mg D and 500 mg Q for 3 consecutive days.
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Charles Grashow Were you able to obtain a prescription online or through a physician? Also, what do you think was responsible for the side effects between the two sources of Dasatinib?
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Dorian Gray
Dr Green was being a pan in the ass regarding the script for D so I got it from another of my doctors. Dr Green's office manager also quoted a price that was much, much higher than what I paid. From the same pharmacy.
My wife took 50D and 500Q for 3 consecutive days and had very mild side effects
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Charles Grashow The first time I took Dastinib I was violently ill. I was afraid to take it again and made sure I had prescription strength nausea medication onhand in case I needed it. I tried it again last night but only took half the recommended dose of 100mg. So with 50mg I had no problems at all. Had your wife took the recommended 100mg dose she may have had a different outcome.
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Charles Grashow are you a patient of Dr Green?
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Karl
Yes I am
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Would also like to know the answer to these questions. Thanks.
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I am one of Dr Greens patients and he gave me my pills through a compounding pharmacy he uses. The first time I took the pills I thought I was going to die. I had fever, chills and threw up constantly for several hours. I'm afraid to do another dose but I paid good money for the pills and I want to reap the rewards from this medication if there are any. The next time I do a dose I am going to take a prescription pill for nausea at the same time. Overall on the rapa and all the other supplements I am on I feel better than I have at any time in my life. Dr green said I may have had a lot of senolytic cells and that is why I was so sick but I'm not so sure because I have been on rapa, metformin and doing fisetin doses for some time now and I wouldn't think I would have much of a buildup. I'm 52 not 82 as well.
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JOHN I've taken three doses of D&Q over the last couple of years and never had a problem.
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Larry I guess everyone is different. Like I said I took 50mg last night and was fine and I just took 100mg a few minutes ago and we will see what happens. I take a lot of supplements so maybe one of them had a bad reaction. I will update in a few hours.
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so far so good my first full dose without any terrible side effects. I made sure to not take my other medications and supplements just in case. Will do day 2 here in a minute. Still had a headache and uneasy feeling but nothing big like the first time.
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Finished my first 3 day dose of D&Q. I felt good about half the time and the other half had a headache and a general feeling of something being "off". Today 48 hours after my third dose I feel good. I will update with any noticeable changes in the next week.
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Hi John, perhaps you just had a high senescent load and that flushing out caused you problems. Good luck!
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I take 100mg of dasatinib daily without side effects. The main risk is getting pleural effusion. I also take 2g of metformin daily. Would I add daily quercetin to the mix?
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Stephen Lewis are you saying you take these everyday? Or just for a few days as in the protocol?
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Karl Yes, I take them every day under prescription.
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Bad news regarding Taylor Made Compounding ; https://www.bloodhorse.com/horse-racing/articles/244487/compounding-pharmacy-admits-guilt-in-federal-case
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Ludovic Debels Nothing bad really - these SARMs are sold via many online vendors, just not licensed pharmacies. It is because it was a regulated pharmacy that it got in trouble. Before that, Ceretropic sold all of those but decided to voluntarily close shop after sensed where the winds are blowing.
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Wanted to share something I learned. I've been a patient of Dr. Green's since 2019. I'm on the 3rd day of 100mg Dasatinib, 1425mg Quercetin, and 2000mg Fisetin w/ 500mg Azyithromycin. I do this combo every 3 months. The morning after taking Dasatinib - I usually have a headache / frontal lobe. I've taken Tylenol with a little caffeine previously when it was too intense - and that helped but didn't feel right. This morning I took 2 Serrapeptase (Arthur Andrew brand Serretia) also with a little caffeine - and the headache was gone within 30-45 minutes. It made taking this 3rd dose that much easier. Hope this helps someone out there. YMMV.
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I discovered if I take an extra dose of NAD precursor during the day I’m taking D & Q it takes the side effects away. So perhaps the drugs deplete your NAD and that’s why you feel off. Similar to what happens with a hangover. Just thought I’d share my experience.
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Jared
How do you know that you aren't suppressing the senolytic effect? I take the flu-like symptoms of D+Q as an indication that senescent cells are being disassembled and the debris in the bloodstream is producing the symptoms.
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JGC I don’t know that. But since it’s several half lives later I assume it’s after effects of the senolytic effects.
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