Richard Miller on Peter Attia podcast regarding rapamycin
Paul a very good blog. Rapamycin, Acarbose and a new one for me Canagliflozin. This might be better than Metformin. What was interesting was that Acarbose lowered HbA1c which is not easy to do. Progress marches on little by little. Richard Miller said it right about all those Dr.'s making a lot of money on NAD precursors and ripping people off. That includes Sinclair. Sinclair had already ripped off the drug companies with Resveratrol. No NR/NMN found in tissues where it is needed.
I just started taking Arcarbose instead of Metformin. My plan was to take 100 mg Arcarbose with meals 3 X's a day. The reason that I was going to try and change was the Arcarbose seem to do a better job in control glucose and extending lifespan. It also had a bigger impact on HbA1c which for me was hard to get lower. Well I took 1,000 mg Metformin at noon and 3 hours later had a meal. Took 100 mg Arcarbose with that meal and 30 minutes later felt bloated and just over all bad. Took nothing else until next day. Told myself to not take them together. Next day took 50 mg instead of 100 with my meal and felt great no problems. So that is where I am at at this moment. Read on the web that it takes awhile to let your body adjust to Arcarbose just like it did with Metformin. WIll report back when I have more data. I would not take both together. I took Metformin to control Glucose and just like you I was pre-diabetes. Metformin schedule was 500 mg morning, 1000 mg 12-2pm., and 500 mg at bedtime. Really reduced my cravings for carbs, and helped reduce fat and weight gain. Hope Arcarbose does same because here in spain 40 50 mg tablets only cost $2. Metformin is also super cheap
Hi Van , nice to hear from you, your point of view is interesting, and thanks for writing all those details, it take time. I want to learn more about mixing different drugs, the order and the space between them. Sometimes I re listen podcasts/youtubes because I always miss something.- Today I am listening Richard Miller podcast again
I am 42y old, and 3y ago I was dignosed infertile. I been in human reproduction assistance with no luck, no sperms production. They told me that they can't do anything more. So I get out there to find out that there are a lot of interventions that I was missing and help me to be now dad.
It is a learning curve. I started with NMN and Resveratrol (I bought the smokeseller book ), and then I realized that there are a lot more things, like mTor, Senolitics, FMD, HIIT and SIT. To make it short, I am better and still learning a lot. There is still a long road ahead.
Beside my mutating over the time daily "cocktel" ( I make it for 20days, 60cups, 3 cups a day, morning, middle day and night), I also do once a week 5x1" SIT swimming pool, and try to do everyday jump rope just few minutes, like 150jumps, not a big deal. I do not spend to much time doing exercises, which is a field I should improve.
Beside the daily maintenance. I did FMD many times with senolytics starting on the 2 FMD Day, 3 dosis/day, for 2 consecutive days (each dosis: Fisetin 400mg, Quercitin 400mg, Pterostilbene 100mg, Apigenin 53mg (2 frozen chopped parsley cubes) / per dosis), olive oil and cherry tomato. This year want to include spermidine.
Previous images and this ones are some how old. (fisetin, quercitine and resveratrol)
Van I forgot to mention that I reduced aspirin from 100mg to 50mg and a few month ago to 25mg to avoid brain bleeding, https://www.youtube.com/watch?v=A8dL_Y4V3kI
I would like to know which combos are safe and sure to work with Rapamycin, Acarobse, Canaglifozin.
Btw, where are the results from ITP 2017 and ahead ? Some interventions starts at 16months of age. Many of those interventions are already finished and I could not find those results in the nih-itp website, like Phase II - Rapamycin/Acarbose