Fred Cloud What age is that?

Hello World He said he is 56 years old. I am not sure what you are asking

Fred Cloud You said that they are old enough to benefit. I'm just curious if there is a consensus in terms of the minimum age for which a person might benefit

Hello World How old are you?

Fred Cloud 40

Hello World Dr Green the rapamycin guru will start treating patients starting at 40. Rats in the study were given rapamycin during middle age only and it showed life extension.

Paul Beauchemin What do the blood tests report on?

John Hemming the ones that changed

eGFR - much higher (was way out of range for 5 years)

creatinine (much lower - was way out of range for 5 years)

RDW  (lower)

Paul Beauchemin Thank you for this.  To me what is curious about the question as to what improves cellular health is how to measure it.  Human beings often measure aging by how people look.  Actually from the perspective of inflammation and the status of hair that is not an unreliable measurement.  The question then is if we are trying to improve our cellular health how to measure that in a quantitative sense.

John Hemming I've used epiagingusa.com for epigenetic tests and the Levine calculator and aging.ai to assess this. The Levine calculator uses RDW and creatinine as two of the variables in their model, so my bio age dropped from 66 to 53. Both the epigenetic test and aging.ai are within a few months of the Levine calculations

Paul Beauchemin Thank you for this. Much that I think measures of things like methylation are helpful there is an argument to concentrate on more easily observible things.  I have done a list on another thread.  If you are 66 I am younger than you being 61. However, we are of an age where physical deterioration is likely to be different.  For example I can hear sounds at  14kHz.  Sadly I have not measured that previously so I only know the result as at  December 2021.  Today I bought a grip measuring device.  That gives me another non-invasive tool for measurement.

John Hemming I heard something from Sandra Kaufmann expressing some concerns about Rapamycin and I think I have found the research.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135256

John Hemming The rats were 2 weeks of age. Rats reach sexual maturity at 5 weeks. I haven't heard anyone recommending rapamycin before adulthood. Not that I am a doctor, but I tell people not to take it before you're fully grown.

T F Thanks for that.  Obviously different people have different protocols for improving their cellular health.  It may be that Rapamycin is part of this, but there are other ways of affecting mTOR (much that it was not named after the other ways). I have no firm view.

Paul Beauchemin I've been taking 8mg/week. I've also noticed significant improvements in eGFR, and liver enzymes ALT/GGT, and a massive reduction in URIC acid. I haven't read too many references to Rapamycin and uric acid, but apparently, it's good thing to have a lower level. I am high daily exerciser, an no apparent impact on power output, muscle build, recovery. 

Paul Beauchemin What is your dosing for rapa?

Chris 15 mg every 2 weeks

Brin Chikovski great and encouraging, thanks! would be nice to have a list of comments from those who don't experience any effects and/or experience negative effects. unfortunately, these people may be less likely to share their experience in a forum like this . 

Chris Los Rapamycin side effects that people are experiencing are listed here: https://www.rapamycin.news/t/side-effects-of-rapamycin-part-2/71

Brin Chikovski Thanks a lot!!