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D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
For my May 15-18 senolytic session I tried something new. In a recent Foresight Institute talk available on YouTube, James Kirkland identified the flavonoid Luteolin as a senolytic. There have also been reports that GLA and Gingerenone have strong senolytic properties. Therefore, on the theory that in a senolytic session the more different senolytics the merrier, I decided to combine these three with the D+Q+F+P senolytics that I has already been using. It is not clear how much of the new items one should take, so I had to guess. And so, in late mornings of this past Sunday, Monday, and Wednesday I took the following senolytic cocktail:
1 x 50 mg Dasatinib (From India; I usually take 100-200 mg, but only 3 tabs left)
4 x 475 mg Quercetin (Swanson)
10 x 44.5 mg Bio-Fisetin (Life Extension protected caps with x25 bioavailability)
1 x 10 mg Bioperine (Swanson)
8 x 165 mg Luteolin (Geroprotect Autophagy Renew)
10 x 200 mg Ginger Root Extract (Swanson, Gingerenone amount unknown)
5 x 400 mg Mega GLA (Life Extension, with 10 mg Sesame Lignans)
That’s a dismayingly large number of tablets and capsules, but for these three sessions I took them with water all in one sitting. On Sunday evening following the first session I experienced a mild headache, mild intestinal cramps, and a feeling of unwellness. On Monday evening I experienced stronger versions of these symptoms, plus frequent bowel movements and a mild fever. On Tuesday I was scheduled for a 12:15 PM dog-agility training class, and I felt unwell enough that I almost skipped it. My performance at class was sub-par. When I returned home from it, I decided to defer the final Tuesday senolytic session by a day. I went directly to bed and took a long nap. On Wednesday I felt better, and I did the final senolytic session at about 11 AM. This time the side-effects were not as strong, but I had a bowel movement that included a rather strong burning sensation, which I suspect was due to the exit of the Ginger Root Extract. While I was sleeping last night from 3-7 AM I experienced mild intestinal cramps. On Thursday (today) all the negative symptoms are gone, and I feel very well and energetic, with no bodily aches and pains at all.
I attribute the negative side effects described above to (a) the residue of cleared senescent cells in my bloodstream and (b) the presence in my digestive system of molecules that are usually not present and are temporarily producing intestinal inflammation and cramping (and clearing senescent intestinal cells). The observed effects were quite a bit stronger than I had experienced with D+Q+F+P sessions in October and in February, and I think the three added ingredients are achieving increased senolytic action and perhaps are clearing senescent cells of more diverse cell types. I take the mild headaches as an indication that senolytic molecules are getting past the blood-brain barrier.
All in all, I think my experiment was a success. I plan to repeat the use of this cocktail for my next sessions in August.
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Is there any way of measuring senescent cells in the human body? I am afraid we may be poisoning ourselves without a proper way to measure to see what is happening to our bodies. Feelings can be deceptive as many feel great after recovering from major illness, but it is doubtful if the illness was beneficial. The best forms of proof for me would be hair regrowth or spot removal (i.e. liver spots) or some other physiological change that can be measured. Is there anything out there to prove senescent cell removal in vivo? Thanks...
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I've long been fond of CRP testing, and short of more accurate & inexpensive tests to measure senolytic activity, it may be best. However, almost all medicine & even holistic drug recommendations are based on weight. Far more accurate, & useful, would be to include age, health conditions, etc. For instance, CRP is mostly to catch over-all inflammation, which is likely root of all disease & aging, but shouldn't individuals with cancer, take more -- and/or more frequent -- dosing?
Separately, maybe 30 years ago, as an LEF member, I did blood work through them, and despite checking the appropriate boxes, LEF used my blood results in a study (I found out through another error by LEF.) And with LEF, publishing my results -- even without my ID -- is with purpose of selling various LEF products. That & other experiences, have resulted in my not trusting LEF, although I still use some of their products, although buying from AMZN is same price as being an LEF member