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Re: Sources for inexpensive prescription Rapamycin @are we there yet There are problems with every healthcare system on earth. The problems with Canada's system get amplified greatly in the United States because of the many economic interests a…
- Iðunn
- Iunn
- 5 yrs ago
- 3
- Rapamycin Discussion
- Reported - view
Re: The vagaries of lab testing Here is Oxford University Press' SI Conversion Calculator. Does that clear things up? Also, are you looking at free or total T on each test? And are they using similar testing methodologies?…
- Iðunn
- Iunn
- 5 yrs ago
- Test Results Discussions
- Reported - view
Re: The purity of Lucidias-brand Dasatinib @Louise B Andrew I wouldn't assume based on a single test of a single bottle that a given supplier can be relied upon for purity and potency going forward,…
- Iðunn
- Iunn
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Antonia Gauer Note that this is a conclusion that in no way follows from what they've laid out. Tocotrienols delay senescence (in cells in a dish, for reasons that have nothing to do with why cells…
- Iðunn
- Iunn
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Staffan Olsson Yes, but there are no data supporting that tocotrienols have senolytic activity, even in cells in a dish.
- Iðunn
- Iunn
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Staffan Olsson Sure, but you want to be experimenting based on plausible preliminary data 😉. It's one thing to see something like fisetin — which has substantial senolytic effects and low toxicity…
- Iðunn
- Iunn
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Dan Nave Sure, but that's generic information on how compounds can affect drug metabolism. The question is whether the specific effects of piperine can increase the bioavailable levels of fisetin…
- Iðunn
- Iunn
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Dan Nave I'll note again that "I don't think there's any evidence that piperine/BioPerine enhances absorption of flavonoids generally — just curcumin."
- Iðunn
- Iunn
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @JGC "To my understanding of the metabolic pathways involved, there is no known interaction on that front."
- Iðunn
- Iunn
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Staffan Olsson @Don It's important to note that curcumin has only been shown to be senolytic in cell culture models: there is no evidence at all that taking it as a supplement kills senescent cells…
- Iðunn
- Iunn
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @JGC But he was asking about combining grapefruit juice with fisetin, not dasatinib. To my understanding of the metabolic pathways involved, there is no known interaction on that front.
- Iðunn
- Iunn
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: The purity of Lucidias-brand Dasatinib @Vincent Stona Have you considered submitting a sample of your order to Johnny Adams for testing? Maybe you could split the cost with anyone who shares your order.…
- Iðunn
- Iunn
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycim vs dasatinib vs quercetin/theaflavins @DanMcL @Seaside I don't believe that circulating cytokines are reliable indicators of senolytic activity ... there was no clear effect on these in the recent dasatinib + quercetin clinical trial…
- Iðunn
- Iunn
- 5 yrs ago
- 1
- Test Results Discussions
- Reported - view
Re: Fisetin to Clear Senescent Cells @JPA On quality, both Swanson and Doctor's Best use Bioriginals' branded Novusetin raw material: this is a well-established company with a reliable quality reputation.
- Iðunn
- Iunn
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin @JGC I think a person should be very careful about doing anything that will increase the permeability of the blood-brain barrier.
- Iðunn
- Iunn
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin @JGC Bioperine certainly increases the absorption of curcumin, although maybe not of the parent compound, but I don't think there's any evidence that it increases absorption of flavanoids across the…
- Iðunn
- Iunn
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Intro to rapamycin @DanMcL Huh? You quoted him as saying "There is a change in the first step to substitute metformin and various forms of calorie reduction in lieu of rapamycin"
- Iðunn
- Iunn
- 5 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells @JGC I don't think there's any evidence that piperine/BioPerine enhances absorption of flavonoids generally — just curcumin. Or do you know of any? And the mechanism isn't really understood,…
- Iðunn
- Iunn
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Intro to rapamycin @DanMcL As I've posted elsewhere, it's not clear that metformin inhibits mTOR to any significant degree outside of the liver, and it clearly cannot substitute for rapamycin.
- Iðunn
- Iunn
- 6 yrs ago
- 2
- Rapamycin Discussion
- Reported - view
Re: Rapamycin in humans @albedo Metformin clearly is no substitute for rapamycin. Metformin inhibits mTORC1 is in vitro, in implanted tumors, and in the mouse liver: no one has shown that it inhibits mTORC1 in actual…
- Iðunn
- Iunn
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age @JGC Is the current link to the spreadsheet based directly on the Levine algorithm, or your modified version where you tried to "correct" it to align more closely to the derived methylation profile?…
- Iðunn
- Iunn
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Re: "Senolytic Activator" and Extended Fasting … This is kind of moot, since there's no evidence that the theaflavin + quercetin supplement actually kills senescent cells: see my post here.
- Iðunn
- Iunn
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycim vs dasatinib vs quercetin/theaflavins There is currently no evidence at all that theaflavins selectively kill senescent cells: if you read the article in the magazine or on the website, they're just basing the product on studies showing…
- Iðunn
- Iunn
- 6 yrs ago
- 2
- Test Results Discussions
- Reported - view
Re: High quality, affordable rapamycin (and other anti-aging meds) @Snowbird 1. Dr. Mark Hyman, the Medical Director at Cleveland Clinic’s Center for Functional Medicine, the Founder of The UltraWellness Center, and a ten-time #1 New York Times Bestselling Author,…
- Iðunn
- Iunn
- 6 yrs ago
- 2
- Announcements
- Reported - view
Re: New blood tests can reveal your life expectancy @JGC But, hang on: the DNAm PhenoAge is built up from the Phenotypic age, not the other way around — and "the phenotypic age measure used to select CpGs is a better predictor of morbidity and…
- Iðunn
- Iunn
- 6 yrs ago
- Assessing Biological Age
- Reported - view

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