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Re: Rapamycin and a possible link to accelerated Alzheimer's Disease This is from Dr. Alan Green's https://rapamycintherapy.com/ : "Researchers used a mouse model of AD called 5XFAD. This model overproduces massive amounts of amyloid.…
- UB
- U_Bednarzik
- 1 yr ago
- 1
- Rapamycin Discussion
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail A reliable (and relatively well reviewed) supplier is Towada Products via Indiamart--Ravinder Gandhi is the contact there. They offer several manufacturers,…
- UB
- U_Bednarzik
- 2 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail Remember reading that on Dr. Green's senescence-related website (https://senolyticstreatment.com/) regarding the time-line from senescence to SASP. It's too bad about the discomfort at your present…
- UB
- U_Bednarzik
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail That makes sense, but what would happen if you increased your treatment frequency to, say, once a month?...roughly the amount of time it takes for a senescent cell to start secreting SASP (and…
- UB
- U_Bednarzik
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail @JGC After reading and benefiting from so many of your contributions to this forum, am trying to think of an effective analogy that might persuade for more frequent dosing.…
- UB
- U_Bednarzik
- 2 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin vs Metformin @Juan Daw Have researched this further and summarized Withaferin A (in a constantly updated health-supplement worksheet) along with possible use with Fisetin to supplement (or supplant ?) rapamycin.…
- UB
- U_Bednarzik
- 2 yrs ago
- AMPK Activation
- Reported - view
Re: A hypothesis about Senescent Cells @John Hemming Thanks for your exhaustive research so far. Like you mentioned in your blog, there are likely many factors involved in producing the essential citrate carriers (of Acetyl-CoA) required…
- UB
- U_Bednarzik
- 2 yrs ago
- Senolytics Discussion
- Reported - view
Re: Safe Rapamycin and Metformin mimetics @Juan Daw Thanks for the link and info. If you could only take one supplement to directly increase NRF2/glutathione levels than Sulforaphane would be overwhelmingly the best choice at over 80% oral…
- UB
- U_Bednarzik
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Safe Rapamycin and Metformin mimetics @cjacek Thanks for the link, just read through it. Like to get more into the underlying mechanisms of supplements/methods so further researched Ashwagandha (incl.…
- UB
- U_Bednarzik
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Safe Rapamycin and Metformin mimetics @Juan Daw Thanks for the suggestion. Haven't found any direct studies yet regarding Withaferin A mechanism of action relating to MTORC1 inhibition, but do see several autophagy related studies that…
- UB
- U_Bednarzik
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Safe Rapamycin and Metformin mimetics Have also been interested in rapamycin and metformin mimetics, if anything to bolster their effects. Believe that creating the same desirable outcomes through multiple pathways (i.e.…
- UB
- U_Bednarzik
- 2 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Bio-Fisetin, a x25 Boost in Bioavailability? This section of the paper refers to lymphoblastoid cell types, which are a type of white blood cell line infected with a virus...and not a normal healthy cell.
- UB
- U_Bednarzik
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: metformin negative study Recent mouse and rat studies indicate still a positive benefit and it synergizes with rapamycin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013015/ (ITP study that covers a several compounds) &…
- UB
- U_Bednarzik
- 2 yrs ago
- General Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells Just wanted to share this older study regarding the reduction of Fisetin methylation (into less effective geraldol) in the liver when combined with increasing amounts of red wine: https://pubmed.…
- UB
- U_Bednarzik
- 2 yrs ago
- Self-Experimentation
- Reported - view

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Joined: 28 Dec 2021

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