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Re: Fisetin ( + quercitin)
Okay, here's the new Chinese bulk fisetin source from eBAY found by @djmichel djmichael and discussed above: Pure fisetin Powder at a cost of 22 dollars for 10 grams. link attached. https://www.ebay.…
- Steve_Harris
- 6 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Azithromycin (Zithromax) as senolytic; a note of caution
@Dan What was the antibiotic?
- Steve_Harris
- 6 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin Dosage Calculations
That's about right. Normally you will do pretty well on conversions if you just imagine yourself eating mouse chow. If you were eating 3 Cal/g chow with 500 mg/kg fisetin,…
- Steve_Harris
- 6 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin ( + quercitin)
@djmichel Good find. Although the effects of PARP inhibitors and pro-apoptotic agents is likely to be mixed, I am encouraged that life time feeding, at least in this preliminary report,…
- Steve_Harris
- 6 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Azithromycin kill/eliminate 97% senescent cells
@Steve Harris Unlike azithromicin, fisetin is non toxic. The dose based on mouse studies is roughly 500 ppm in food chow or (for humans) something like 100 mg 4 times a day (400 mg a day in divided…
- Steve_Harris
- 6 yrs ago
- 1
- General Discussion
- Reported - view
Re: Azithromycin kill/eliminate 97% senescent cells
@are we there yet
- Steve_Harris
- 6 yrs ago
- General Discussion
- Reported - view
Re: Fisetin ( + quercitin)
@Rob8311 I mean "bold" by feeding some stuff to your dogs which has never been fed to dogs before (at least not in the recorded science literature--I cannot find one report of dogs and fisetin).…
- Steve_Harris
- 6 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin ( + quercitin)
@Rob8311 You're a bold man feeding that much bioflavonoid to a dog. Dog's don't have primate livers, and things like chocolate are quite toxic for them.…
- Steve_Harris
- 6 yrs ago
- Senolytics Discussion
- Reported - view
Re: NAD+ Patches
@DanMcL The "nada" is from the fact that charged ions like Mg2+ are not expected to cross skin from just application. If they did, a swim in the ocean would kill you.…
- Steve_Harris
- 6 yrs ago
- 2
- NAD+ Restoration
- Reported - view
Re: Fisetin ( + quercitin)
@djmichel Not immediately. I had been using Swanson's, but that's already been mentioned.
- Steve_Harris
- 6 yrs ago
- Senolytics Discussion
- Reported - view
Re: NAD+ Patches
Call me skeptical, but is there even a hint of data in published literature that NAD+ gets across skin in quantities large enough to affect physiology, iontoporesis or not?…
- Steve_Harris
- 6 yrs ago
- 2
- NAD+ Restoration
- Reported - view
Re: Fisetin ( + quercitin)
@djmichel Note the stuff from Trillium is not 100% fisetin, but raw fisetin-containing herb (Gleditsia thorn powder). It might be anywhere from 10% to 50% fisetin.…
- Steve_Harris
- 6 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Azithromycin (Zithromax) as senolytic; a note of caution

This is the problem with "cell studies." The authors who found this result decided to look at what they called a "low dose" of azithromycin (AZM) on cells.…
- Steve_Harris
- updated 6 yrs ago
- 14replies
- 1554
- 5
- Senolytics Discussion
Re: Azithromycin kill/eliminate 97% senescent cells
This is the problem with "cell studies." The authors decided to look at what they called a "low dose" of azithromycin (AZM) on cells. They found that 50 uM did nothing, and they needed 100 uM.…
- Steve_Harris
- 6 yrs ago
- 3
- General Discussion
- Reported - view

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