Oral NAD; wasting our time and money?
Watch the video for a in-depth explanation of current research on NAD, particularly oral form. She discusses the problematic nature of taking oral NAD precursors and whether they actually make it into your cells (spoiler; generally they don't if I'm hearing this right, this is one of her faster technical videos).
This illustrates a point I've been wondering about for some time. The Oral NAD is expensive and many of us are also doing patches or IV's. For those doing regular intravenous application, is the Oral supplementation not worth it?
Note: NR is quite expensive largely due to a patent, at least is what I heard. It used to be cheap, but of course once it got popular the price was jacked up to what the market would bear.
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Certainly a legitimate concern. A lot of money being spent on NAD supplements that might not work.
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Recently been following this idea here and elsewhere and I'm coming to conclusion oral administration is not efficacious. Possibly increase effectiveness with absorption modifiers like grapefruit, quercetin, etc., but I haven't seen studies on measurable or conclusive outcomes on that either.
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And yet, the mice in Sinclair’s lab drank water with nmn and showed significant change
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Paul Beauchemin mice.
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I came across this possible concern when I was reading an article by betteraging, but there was information lacking regarding alternative methods, so what is the current state of this? If oral intake of NMN might not be efficient, what other ways are at least potentially relevant?
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IMO she has an agenda she makes a lot of claims like:
1) NAD+ there is no evidence to really support that NAD+ increases mitochondrial activity
and
2) Because of increased mitochondrial activity it's dangerous because cancer cells will grow and proliferate faster
Both of these things can't be true at the same time. In my opinion she is not objective and wanted to discredit NAD+ therapies. So IMO she is not an authoritative source on this. I don't trust her necessarily.
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To be fair to Dr Patrick, she said that pro-inflammatory senescent cells when exposed to nad+ precursor became cancerous, she said that further studies are needed to find out if overall cancer risk is raised.
In my mind the following are unclear with respect of nad+ precursors:1. Do nad+ precursors raise the max/average lifespan in any species? If so how much? The two studies I looked at, one indicated no lifespan extension in mice when supplementing with niacin and the other very recent talked about some extension in nematodes and also mentioned saturation levels vis-a-vis Sirt1. That is there is saturation point beyond which Nad+ simply doesn’t do anything.
2., how nad+ precursors stack up in max life extension or health span vs aspirin, resverarol, Metformin, acarbose, rapamycin? My opinion is that nad+ precursors are less effective. But I’m open to discussion on this.
3. bang for the buck. For the money you spend how do nr or nmn compare to those listed in #2. My opinion is much lower.4. Can nad+ precursors be taken together with other treatments shown in #2 above safely and effectively?
