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Very interesting! EWOT, Rapamycin, Klotho,..the future is now!
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posted this on another thread and only one person noticed. I think this is an extraordinary synthesis. I've ordered a live02 EWOT machine since then. Only need to add klotho to my regimen.
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Paul Beauchemin I watched a dozen videos from the live02 channel and still have no idea what the live02 machine does. Do you know what it does?
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Fred Cloud The idea of varioxia is to upregulate HIF. There are loads of papers on this.
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John Hemming Thats great, I still have no idea what the machine does.
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Fred Cloud The main point of the device is to create hormesis - a stress on the body - in this case regarding Oxygen demand (exercise can create hormesis on the muscles)
LiveO2 device consists of an oxygen concentrator, a big bag and a mask. The concentrator fills the bag with 85-90% O2. You then put a mask on and breath the concentrated oxygen. For EWOT (exercise with oxygen training) you need a device like an exercise bike to use while breathing the concentrated O2.
LiveO2 also sells an upscale model that put 14% O2 in part of the bag. Then you can switch between hypoxia and hyperoxia during exercise.
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Fred Cloud It depends on what detail you want.
https://pubmed.ncbi.nlm.nih.gov/33466421/
is relevant
so is
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Paul Beauchemin Thanks Paul for explaining. If it is the basic model then it is basically exercise with oxygen? I guess I was expecting something more elaborate than that. Maybe the switching back and forth between high and low oxygen is where the magic is. Its hard to tell in their videos which therapy the people are using as they discuss the game changing results.
How do you plan to use it?
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Fred Cloud From what I gather the variation in oxygen levels is most important - even going from O2 rich to normal creates the effect (speculate that this is most of the effect from hyperbaric O2). I think switching to the low O2 state probably pushes this to the next level. I assume its mostly elite athletes that wanted that feature as it mimics training at 10,000' elevation. Dropping back to sea level leaves the blood quite O2 enriched.
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Paul Beauchemin Ok, now it is starting to make more sense, thank you for the deeper insight. btw, I know someone that uses a home hyperbaric with oxygen concentrator daily and says he loves it and on the surface it didnt make sense as a hyperbaric should concentrate the oxygen already, but now it makes a bit more sense. It is a home unit which are limited to 1.3 atmospheres I think and perhaps the extra oxygen mimics the higher atmosphere pro units.
Well let us know how you like your unit. I guess the only downside is that you have to exercise at home since you are tethered to the machine. I know you mentioned you like mountain biking at altitude, so I guess you are going to use this when you arent outdoors?
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Fred Cloud The issue is the partial pressure of Oxygen. Then you have the reversion to norm which upregulates HIF. This is not something for just elite athletes. It matters to anyone who wishes to improve their cellular health.
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Fred Cloud I do like to mountain bike but it takes 2-3 hours out my day. This EWOT promises big results in a 15 minute session 3-5 times a week.
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Paul Beauchemin There is an interesting question as to what research evidence there is that 15 mins of EWOT upregulates HIF more than say 20, 30 or 60 minutes just on an oxygen concentrator.
The O2 concentrator without exercise has the advantage that it can be used 3-4 times a day without really disrupting the daily schedule.
In the end it is all about the generation of Reactive Oxygen Species (ROS) by the mitochondria and that depends upon the partial pressure of Oxygen in the capillaries going into the mitochondria. There is research evidence that points to a minimum partial pressure of about 60% of the atmosphere in the lungs to kick this off. it also indicates that the greater the partial pressure the more it happens.
I intend experimenting with mild hyperbarics, but that is something that is disruptive. I may try hyperbarics up to 2 ATA later that could take the partial pressure of Oxygen up to about 1.9ATA compared to the normal 0.21ATA that we breathe. The research indicates that 0.4ATA has no effect.
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John Hemming I would conjecture that it has to do with partial pressure of CO2 created during exercise. Going from low O2 to high with high levels of CO2 in the blood may accelerate oxygenation of the blood.
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Paul Beauchemin The level of oxygen dissolved in the blood which is the thing that influences the availability of oxygen to the mitochondria varies according to well known scientific principles. Warmer blood is likely to have more Oxygen, but the level of CO2 should not have any effect. I accept the situation with Haemoglobin is different, but I would think if Haemoglobin is transporting CO2 it has a lower capability of transporting O2 although it is in a different direction. Hence I don't think this is a factor. Greater blood pressure might be.
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John Hemming https://youtu.be/gFH-zGZekT8
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Paul Beauchemin She refers at the end to this paper which I had not read before
https://www.sciencedirect.com/science/article/pii/S1568163721000143
I think to summarise that as a rule too long a period of hyperoxia (whether that be hyperbaric or not) is harmful. However, a short period followed by normoxia kicks off HIF. The more recent research where this has been done have not AFAIK highlighted any difficulties from this.
The two main components to my own cellular health protocol are exogenous Melatonin and the Hyperoxic-Hypoxic paradox. That's combined with a range of additional supplements.
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I am using 20 mins from an O2 concentrator without exercise. That means the O2 concentrator can cope with the demands for litres of O2. It also means I am wearing it at the moment and can work and do many things whilst doing this (including sipping tea). The evidence is that O2 concentrations over 40% have a Hyperoxic-Hypoxic paradox effect with higher partial pressures having more effect. What is needed is for the cell to perceive a reduction in ROS. Hence it needs a stable state to measure against. I am using at least 20 mins, this protocol has only 15 mins, but with exercise which may create more ROS. I am expecting to try some hyperbaric oxygen at 1.3ATA, but have not got to that point. I have seen some metabolic effect from the O2, but nothing of massive substance.
