Fisetin experimentation one year (reposted as topic for info purposes)
Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound. I honestly do not know if this is the senylotic effect or some kind of interaction with fisetin in other ways.
To get it out of the way, I will give the fast and short version. I am taking Swanson’s Fisetin. I take around 2g a day for 3 days( now 2.5g). I repeat this for 3 or 4 times with varying intervals (I was trying to find optimal intervals).
My my first regimen was 3 days treatment with a 2 week delay, then a 3 week delay, then a 4 week delay, then a 2 month delay. I am now convinced a 3 week delay is the minimal amount of time you want taking this the way I am, though I will continue with 4 week delay for safety sake and because of my own observations.
So results. Well I feel like this must play on hormone levels in the short term. Immediately after starting a 3 day regimen, usually on day 2 or 3 I feel strong as hell. In particular my legs are tight and super strong. My muscles in general are firmer and overall strength is amazing. My mind is clear, thinking concise anddynamic. I feel more dominant, self confident, and aggressive. Libido is enhanced as well. This all led me to believe that this acts as a testosterone mimic or elevates testosterone in the blood which is why I cycle monthly and then take a few months off every so often.
i can tell you that at the age of 43 this makes me legitimately remember what early 20s feels like. The effects of one 3 day regimen last strongly for 2 weeks and even on for 4 weeks. In particular during week one and two I was amazed at the amount of pure emotion and clarity of the world around me. I could hear and appreciate sounds and colors seemed more vibrant. Mentally I am on overdrive with super memory and crystal clear logical thinking. I remember the first time I took this I was shocked. I was in a cafe just looking at a coke I had bought in a glass amazed at how more real and present it looked. A small thing but it was profound just how the world seemed more alive. It literally felt like going back in time 20 years.
So for long term effects. A stronger posture, better muscle tone, improved gum health, vastly more energy, in fact this has become all the norm after around 8 months of this. Many of the effects I described in the first two weeks following a 3 day regimen do taper off to an extent, but never completely.
As far as side effects there has not been anything thus far. When you are taking the 3 day dose you might get amped up a little jittery but that gives way quickly after the last dosage and it normalizes into a even effect that is positive in nature. I was very concerned about hair loss as I could not believe how impactful this was. But I have noticed no hair loss at all. I cycle it with a 3 or 4 week break to ensure that there is no negative effect on hair or otherwise. With a two week interval I had some scalp itchiness. That was enough to back me off to to four week intervals.
I honestly think that most of what I experienced is not the senylotic effect. It’s way too fast and profound. But I have no ill effects and feel incredible. And overall I have a youthful vigor and look and feel younger. I think a senylotic evaluation, as far as a laymen just observing himself goes ,can only really be done after 2 years or so. However the initial results ( especially gum health) and from what else I can observe are overwhelmingly positive.
I can tell you that this does have an affect and it is profound and noticeable. How much of this is hormone I do not know. But I have other improved health as well, however it’s always tricky to quantify this objectively yourself sometimes.
Good luck on your experiments. Let me know if this has the same effect for you. I just bought Swanson’s with nouvestein. Nothing fancy. Cheap and on amazon.
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As I have noticed from reading forums for years, there are significant differences in how people respond to the same substance or drug. It is rather astounding! Some drugs have shown comments that range from "really worked great for me" to "the worst thing I ever took". I guess that is why we are all here reporting results of our experiments. I wonder how much of this is due to the placebo effect. I have read that in some people/cases long lasting improvement for a certain condition (such as knee pain) can be as high as 50% using just a placebo. This is true even if people were told beforehand that it was just a placebo!!
That is just weird.
There was great story on NPR about this in the past month or so. Can't find it now.
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Paul, I agree on discounting most of those instant effects as placebo.
Just read more on Life Extensions's new product, bio-available fisetin. They claim the human digestive tract converts fisetin into a useless form and that some manufacturer has discovered that a natural fiber extract from the herb fenugreek prevents this. The study is not published yet and is written by the manufacturer:
Akay. A cross over pilot pharmacokinetic study of fisetin 1000mg and formulated fisetin 200mg administered in a single dose to healthy volunteers. Manufacturer’s study (in press for future publication) . 2020.
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David C Not only is fisetin a senolytic but it also acts as an MTor inhibitor.
So this may explain the profound effects you are getting beyond what may be explained from strictly senolytic activity.
Not sure how it compares to rapamycin in its ability to inhibit mtor but it would be an interesting study to compare them.
Have you tried rapamycin to compare the effects?
Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin
https://pubmed.ncbi.nlm.nih.gov/23293889/
Fisetin regulates obesity by targeting mTORC1 signaling
https://pubmed.ncbi.nlm.nih.gov/23517912/
studies have suggested that fisetin inhibits mTOR activity through direct binding
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So, my 2 day of 1.5g of bulk fisetin extract, 98% from cotinus, Chinese origin. Yellow-brown powder.
Tried the buttermilk, yes, it dissolves quite well, after waiting 1.5hr and some occasional stirring.
I am 33 years old, with hypertension and on valsartan.
During the first day, no side fx noted. Blood pressure systolic around 7-9 units lower than usual hour after taking it, dia 5-6 lower, so no significant interaction.
A bit up and hard to fall asleep, but can be placebo.
On the next day, notably more stamina and energy, very energetic and active physically. Like on caffeine. A bit elevated pulse. Definitely not a placebo, as I've experimented with some other substances which claim energy boost, no such result there.
Did not notice any dry mouth or anything of a sort.
Will continue for two more days.
As I am relatively young, senolytic effect was not a main priority, but mainly - chemopreventive (I am a smoker), improving heart condition and overall health, have some bowel issues. Also, a bit of rejuvenation expected as well, as after 30, you anyway start notice some aging effects.
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So I will add one more thing. My sugar cravings have completely vanished. I was eating a lot of sweets routinely. And it was noticeable early on but I never gave it much thought. However I don't crave sweets anymore. And my health overall has improved. I think I had the beginnings of diabetes. And this stuff got rid of a lot of the senescent cells that are postulated to cause diabetes.
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Guys, anyway knows a way to easily distinguish what is fisetin and what is not?
I've ordered some with a Chinese supplier. One was obviously a scam, with some curcuma taste.
Now I've got the other. It is fine yellow powder with a bit greenish hue, from cotinus. With CoA of 99%. Well, this one IS the most bitter tasting thing I've ever tested on my tongue! It is quite stainy, and smells musty.
But what puzzles me, is that Doctor's Best is not bitter at all.
Do you have any experience/ideas of how to figure this out?
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Hi, new here. I am 41 years old and have heard about fisetin senolytic therapy quite long time ago. Since then I've been taking 100 mg (doctor's best) fisetin on and off. Now it's maybe time to go one step further - I might want to take a higher dose. But is fisetin even effective at this age? I read elsewhere that one should be at least 50 years old. But I have arthritis and allergies and many different other ailments. So fisetin might help me. Or maybe instead of taking these high doses like 3 grams for 3 consecutive days every month I might want to take lower doses every day? I read that it also has some senolytic effect too. Sidenote: I am 41 but I look as if I was 30 years old or younger. I assume that this is due to taking a lot of supplements (flavonoids, curcumin, etc.) since I was 24. So these flavonoids work, I guess.
PS. Are there any other anti-aging therapies within my reach ie. as simple as buying supplements. I'm not particularly thrilled at the prospect of buying Dasatinib (or doing similar things) and it may be too early for me to take it as well. I know, I know, there are forums to be browsed here but maybe someone could bring me up to speed.
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Also even if Fisetin is muting signals a good deal it's still quite useful to give the body a non polluted environment to operate in so that it can restore tissue homeostasis. You turn off a large portion of senescent cell signaling for a week or even a few days then that gives the body some time to normalize and rejuvenate. Additionally like I said it must be taking some of the senescent cells out as well. I just don't see the downside to fisetin here. Other than cost.
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1g of "maybe"-99% fisetin in the evening, dissolved in a cup of buttermilk. Then cup's walls became colorated with yellow hue. The compound was bitterly disgusting, but I washed it with drinking a sip of water after 2-3 sips of a compound.
After 30 minutes I felt very calm and warm, relaxed, but energetic. After about an hour a need emerged to take some deep breaths and an urge to yawn heavily. Like you want to yawn every minute, but could not finish it. Then several full successful yawns happened. I went to sleep.
In the morning felt just perfect, fine tuned after a good night's rest. Perfect mood and a boost of energy. No ill effects after the disgusting bitter compound.
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Does fisetin work?
YES!
I experience the visual effect.
As a high-grade prostate cancer patient it has pushed my PSA into the undetectable zone. This is a miracle drug, absolutely lifespan increasing for me. For how long I will remain undetectable is the big question now. Note, I don't have a prostate gland so when my PSA is detectable it represents metastatic cancer being present. Fisetin either kills off the cancer or puts it to "sleep".
500mg, 3X a day for 2 days every 2 weeks. After 2 months PSA test then results.
This suggests those in their 60s should run a course of fisetin as it might avoid or at least delay the onset of prostate cancer. The main factor contributing to the development of this cancer is age, not what you consume or lifestyle. Exposure to dioxin and other chemical agents are the exception to this.
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Joe F. You mentioned prostate cancer. You're likely very familiar with alternative treatments, but in case you're not I'll provide two links of possible interest. Both are related to Joe Tippens. I've investigated his story and it appears to be very true. Whether or not his protocol was truly effective or not, I can not say. But, it sounds like it was.
http://i2b.us/a-drug-for-roundworm-that-can-treat-prostate-cancer/
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Thank you for the info. Prostate cancer cells, and many other cancers too, are, from person to person, different. Within a person's own body many variants of the cancer exist. This is why what works for one person does not for another and a single therapy usually does not kill off all of the cells. By trial, error and accident I have found Fisetin, turmeric and cannabis have driven my PSA into undetectable. This is remarkable. Other things might work but for now I will keep using what works. These cancer cells have a strange ability to adapt so how long this will keep the cancer from progressing is unknown. The cannabis is taken rectally to avoid the high while gaining the cancer suppressing quality. Personally, I hate the high and makes you terribly forgetful making you somewhat of an idiot while the effects last at the high levels it must be ingested to have effect.
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I grew my own. Take a quart jar of high THC buds, fill to 1/3rd full with Everclear, shake and mash the buds about for ~4 hours. Filter the green fluid through a coffee filter, boil off the alcohol in an insta-pot then heat the remains to 170F for an hour. 45 minutes into it add a tablespoon of coconut oil. After cool take a bamboo spear tip and dip it into the black oil to obtain a TINY drop of it and place it in a 00 gel-cap. Place just inside the anus, about one kunckle in. Take at night. You will sleep like a rock. Do 2X a week. The "high" is very slight and you sleep through it. The oil can be obtained commercially but is quite pricy. Taking it orally gets you high and if you smoke it the coconut oil will rip your lungs out.
This helped me gain control of my rising PSA.
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Hello David, I am grateful for your posting. As a chiropractor who has been interested in nutrition and anti-aging for 30 yrs, I am very excited to have stumbled upon senolytics, as compared to telomere lengthening. I am currently experimenting with fisetin and kaempferol. Everything that I have read shows that absorption is enhanced with nano-emulsification. Currently, I am making shakes with strawberry, blueberry, and raspberry, 1500-2000 mgs of fiestin, 1500-2000mgs of kaempferol, protein powder, and 2 tablespoons of olive oil. This all goes into a bullet mixer. The olive oil is for emulsification. Are you emulsifying? If so with what?
By the way, my experience so far is great energy and improved sense of physical well-being.
Thanks
Tom E
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I have read much on fisetin and kaempferol, as many of you have. Look at the peer--reviewed journal information, per pub-med, nih, etc. All glowing for fisetin and kaempfreol. That is a significant change for those traditional medical giants, who have traditionally poo-pooed nutraceuticals.
In addition, Dasatinib may be associated with with pulmonary hypertension, which is a death sentence
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This is the first I have heard of kaempferol..... does anyone know what is the protocol for using it effectively as a senolytic? Bad news about Dasatinib. I have noticed a tightness in my chest when I use it which maybe one of the symptoms of PH.... What are new standards of treatment and are people still using Dasatinib?
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garland This all I have and it's from Pure Bulk. Not a scientifically determined dosage. I have read studies using 5,10,and 15 mgs/kg
Extract Dosage and Instructions
Take 200 mg – 400 mg of kaempferol up to 3 times daily, preferably with food due to its fat solubility.
Since this extract is 50%, this dose range yields 100 mg – 200 mg of kaempferol.
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Thomas E Eliopulos said:
100 mg – 200 mg of kaempferolIf 50% extract, 200mg would give you 100mg of kaempferol
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Hi John. That dosage was on Pure Bulk's web page.
The complete quote:
Take 200 mg – 400 mg of kaempferol up to 3 times daily, preferably with food due to its fat solubility.
Since this extract is 50%, this dose range yields 100 mg – 200 mg of kaempferol.I personally take 1500-2000mg mixed in with my smoothie. Scoop of vanilla flavored whey protein, generous handful of strawberries, blueberries, and raspberries, tablespoons olive oil, about 6 ounces of water. Every 2-3 or 4 days.
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John, I only started taking Kaempferol recently. At 59 yrs old, I have daily back pain from 2 large disc herniations and severe degenerative arthritis (probably resulting from my 31 years as a chiropractor). With other painful joints, I realize that I have entered into that stage of chronic inflammation and the associated disease processes that my subsequently result.
Therefore, my use is to interrupt that process and the reverse some of the ravages of time, aging, and inflammation.
Here is a smattering of the impressive evidence that has helped me in my decision. I am using Fisetin and other nutrition as well: Please look over the following, very exciting:
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I did start doing that regimen. I haven't really noticed anything yet. I am going to give it 6 months plus. I wish that I had easy access to doing biomarkers for aging. I used to do blood works years ago. I would have liked to test at the start and then out maybe 3months. I still need to get behind the science to the mayo protocol. I think it has something to do with clearing the senescent cells with a couple of high doses and then giving time for them to accumulate again. That, and apparently Fisetin can stimulate liver fibrosis. I think milk thistle is a necessary herb, on a daily basis.