Kaufmannprotocol

David H  Can you mention spermidine sources you'd recommend, IE who you buy frrom for your personal experiments?  Is there a cost / dose logic possible like there is for fisetine where some source for spermidine maybe cheaper but less concentrated bu take more??   tnx

Curtis Smith I am aware of three sources of spermidine for consumers in the USA.  I have tried two of them and have the third in our fridge which we will take when we finish the others.

1. The first one that I found was from LZRLabs: https://lzrlabs.net/order-37061865

LZRLabs is located in South Carolina - if you buy in quantity their spermidine has the lowest cost.  Instructions are to take 1 capsule per day.

2. The second one we have tried is: https://spermidinelife.us/

They are located in California but the manufacturing process is in Austria. (All three of them use natural spermidine from wheat germ.). This one is the most expensive of the three.  You take 2 capsules per day.

3. The most recent one that we have is: https://www.primeadine.com/

They named their product primeadine, I suspect because the name spermidine (which is the name given to the active ingredient which was originally discovered in human semen but later found to be in all the cells in our bodies) is controversial and even repugnant to some consumers.  They don't hide the fact that primeadine is spermidine.  As for me, I have heard a few dozen research papers on spermidine and the name doesn't bother me nor my wife.  (It seems to bother women more than men is my observation from reading posts online.)

Primeadine is more expensive than LZRLabs' spermidine but less than SpermidineLife's spermidine.  You take 3 capsules of Primeadine each day.  (The amount of Spermidine in the 2nd and Primeadine I believe is the same.)

We plan to use Primeadine mostly because I trust the founder of the company.  I have been on a zoom session with her and have corresponded with her by email quite a few times already.  Oxford University scientists are also involved with the company.

Instagram: https://www.instagram.com/primeadine/

Facebook: https://www.facebook.com/primeadine/

Youtube: https://www.youtube.com/watch?v=dluDCZg87OA

The founder has had her own health problems and she is very concerned and knowledgeable about health.  I have no financial arrangement with her or anyone else selling spermidine.

I do believe that everyone should be taking spermidine.   My wife and I bought a 6 months supply of Primeadine for our adult son who recently suffered a concussion during an automobile accident.

Finally, we take our spermidine with our evening meal.  It seems to us that it much improves our sleep quality after we changed to take it in the evening.

David H and to all,

Thanks for that great getting started post above!!! Tnx

Might folks comment on their efficacy / value of their spermidine sources?

Other forums discuss fisetin sources and varying efficacy as well.   One here buys from alibaba / China which may have product variability (or not).  Tnx

Jennifer Klein I love rhodiola- there will be a chapter on it in the next bnook I can currently working on

David H I find that spermidine makes me sleepy and that it improvs my sleep. So I take it with my evening meal. 

Staffan Olsson One of our sons and his wife found that spermidine taken in the evening greatly aids their sleep.

David H This is very interesting.  Seeing from the Primeadine Facebook page that spermidine is a prime ingredient in soybeans, why not just make them a regular part of the diet as the Japanese do?  Certainly a lot less expensive.  

Dorian Gray Leslie Kenny the owner of Oxford Health, the company that sells Primeadine, recently mentioned in a podcast that if you eat natto, you don't need Primeadine.  Her comment led me to researching the amount of spermidine in natto.  I eat 150gm of homemade natto daily and my wife eats 200gm daily.  I believe the amount of spermidine in this amount of natto is 20mg or more while the spermidine supplements have 1mg per daily serving.  So when our Primeadine supply is gone, we won't buy it again. If my memory is correct, and I don't know the reason, tofu has little or no spermidine.  Soybeans themselves have more spermidine themselves than natto by weight.  We will stick with natto for two reasons - 1. Unfermented cooked soybeans causes us to have intestinal distress 2. There are multiple nutritional advantageous changes to soybeans when they are fermented and become natto.

The problem with natto for the general public is that most western people don't like the taste and texture of natto. My wife and I are willing to eat any nutritious vegan food so we don't care about the taste.  We have been eating it for one and 1/2 years and we both like it.  We do think that homemade natto tastes better than store bought previously frozen natto (which is mostly available in the USA).

My wife's family is Chinese and I have convinced one of her sisters to try natto.  I explained that it would very difficult to find a food that is better than your health than natto.  Japanese children start eating it early, less than one year old per YouTube videos.

You are right, natto is much less expensive.  We pay about about $40 for a 20 lb bag of small soybeans (small is best for natto).  We buy it direct from a North Dakota soybean farmer who has told us that she doesn't use chemical sprays on the soybeans and the soybeans are not GMO.

David H Great that you and your wife don't mind putting in a bit of effort and thinking to achieve such a positive thing. It's a rare thing today in the age of "packaged" everything. While I don't eat it on a daily basis, I do consume it frequently. My wife is Japanese so we have been eating the healthy aspects of that culture for forty years now. We have Japanese markets close by so it is easy for us a lot of the things that aren't in regular stores. For natto, we usually get this brand: https://www.meguminatto.com Although she has made it herself often as well as Kimchi which we have regularly also.

sandra kaufmann On the page from https://kaufmannprotocol.com/a-note-from-sandy you mentioned that your vision improved. I have read about astaxanthin and carnosine, but I'm interested in what you did if you don't mind telling me more. Thanks.

Jay Orman In addition to the astaxanthin and oral carnosine, I use visomitin (SKQ1) eye drops and NAC eye drops daily. I'm sure the other 50 agents are probably helping a bit as well! 

sandra kaufmann I am now investigating SKQ1. It may be a viable option. My experience with Can-C for about a year is negative for what my opthalmologist calls a baby cataract in one eye. I researched Can-C (N-alpha-acetylcarnosine eye drops) thoroughly with pubmed documents before trying it and afterward. This simple article seems to sum up my thoughts of Can-C at this time : https://www.eyenews.uk.com/education/the-truth-behind-the-headlines/post/the-truth-behind-the-headlines-aprmay-2018 . The SKQ1 route looks interesting.

Jay Orman My wife and I have been using a 4% NAC product from the UK for the last 16 months.  I haven't seen an ophthalmologist nor optometrist during that time.  But my cataracts were worsening my vision so that I needed a new prescription every six months for the year before I started with the NAC.  My vision, as far as I can tell, has not changed during the last 15 months.

https://costcuttersrus.com/products/cataract-clear-nac-xtramax-eye-drops-2x10ml-highly-effective-for-people-dogs

That's the link for them - but I have been ordering it on ebay.

David H Do you have time to explain your process for making homemade natto?