Paul Beauchemin  Do you have a recipe? This sounds interesting. Did you make it for the skin, or were you also wanting absorption?

Moonlitnight just used this molarity calculator

https://www.omnicalculator.com/chemistry/Molarity

curious yes, face and back of hands

back of hands has made amazing improvement. Used to pinch the skin for a few seconds and it would stay that way for many minutes. Now it snaps back in a few seconds.

Paul Beauchemin  Many thanks!

Paul Beauchemin Impressive Paul, how long did you use the rapamycin on your hands before you noticed a difference?

Paul Beauchemin I mixed 3mg in 4 ounces. I think it should be 25 micromolar based on Mark Thimineur post.

Fred Cloud between two and three months I started to notice the change visibly.

curious hard to say about wrinkles

with back of hand you can do a pinch test for elasticity. pinch the skin for 10 seconds and time how long it takes for skin to snap back to flat. For me skin would stay pinched for over 5 minutes previously. Now it relaxes to flat in about 15 seconds. So I can measure it. I can't measure wrinkles

Who knows if it stops aging?

Paul Beauchemin That alone is impressive.  I would not think any amount of moisturizer would have a similar effect. 

Moonlitnight yes I have been using it for almost 6  months now...amazing results.... here is a post I did with a Doctor who gave me the formula... awesome stuff... Since this post things have continue to improve... it is quite amazing on my face and forhead and neck... the arms It is noticeable but more is needed..

Hello Mark...I have some questions but wanted to tell you that I have learned alot about your wonderful recommendations for topical treatment of Sirolimus after experimenting with them myself. I feel they work far better then anything out there however unlike you  I was not totally blown away with my success. Then after rereading your post I realized that you did this 2 times a day most of the time. So after trying that it seemed to make things happen a bit quicker. With this treatment you need to have lots patience as it takes time ... I have been doing this since April.. but my under eyes, neck and forehead is 70 to 75% better and most of the time I only did once a day. Now I am trying to 2 times a day for at least 3 or 4 a week. I did add a retinal product which seemed to help as well. I put it on every night after waiting for bit. I did not try your product Adapolene as I called the company and they did not think that it worked at all for getting rid or wrinkles. However it is supposed to be much stronger then regular retinal products so maybe it would work the same way only better? . Also my creepy skin is maybe 25% better on my arms which is huge as I never thought it would work there. Hopefully it continues to improve. A I am wondering if I apply it in greater amounts than maybe it would be significantly above the threshold for optimal results. If you add too much Sirolimus then the results would be nulified.... What do you think about that. Wishing you well and thanks a bunch for sharing your experience with topical Sirolimus ...it is a huge gift you have shared with us!!!! 

Reply  Like

garland Do you have any before after pictures?

curious definitely it's getting rid of the wrinkles. Has been one study done on this it only does it get rid of the wrinkles and it also gets rid of the senolytic cells after about after about eight months. Research is pretty amazing actually and the doctor who turned me on to the right mixture has had amazing success with his clients. This is a new ball game I've tried all kinds of things to get rid of the sun damage this does a trick at a very cheap price. To quote the doctor he said he knows a bunch of plastic surgeons Who would be very nervous about how effective this stuff is

Fred Cloud Yes.... that is it... the first three months go slowly but 2 times a day makes i faster and some retinol treatments work wonders.... see my post to Dr Mark... I have a bunch of them with Dr Mark... I just posted them there....

garland Work on lower eye bags? 

 curious  Ok I am taking Arbo Trex Dmso/Aloe Vera cream.... 70/30 with Lavender scent mixed DMSO containing 3 mgs of Sirolimus mixed in Liquid DMSO.  I use a mortar and pistol to grind down the pills and then put them in a text tube with DMSO to thoroughly mix them up. Mixture will be Cloudy with dissolved Sirolimus. Then I mix it into the 4 oz cream.... Then I apply topically to my skin. According to Dr Mark the study on this showed that after 8 month  it removed all the senolytic cells from the skin. I used it sometimes two times a day. And added in the past month or so a Retinol product both of which seemed to make the process go faster. It takes patience with this process but the price per month is only about 35 dollars a month. So it save thousands in plastic surgeon money plus you get rid of old cells. Check out my posts with Dr Mark for more details..... 

Michael yes fairly well 70% better I am now using a topical retinol cream to enhance these amazing results even more

garland How long does the mixture you've described above last -using twice daily - before needing to make again? Just trying to determine how much you're using during application. Thanks again

curious I followed what someone else did... an MD Dr Mark.. he has got results so I followed that ...see my other posts in another forum... you will get alot more knowledge...

garland I'm curious. The Arbo Trex Dmso/Aloe Vera cream bottle says "sold as a solvent only". Have you had any averse reactions to using this -sans rapamycin? Do you put it under your eyes?

Thank you!

Michael 

Michael well you can't put it in your eyes but underneath the eye seems to work fine sometimes it gets a little itchy but a lot of them do that

Michael 

Michael 

Michael remember you can be allergic to anything so you always have to be careful when you first start out

garland Thank you, We're you using that before adding rapa? If so, notice any positive effects from just that?

garland Is this what you are using? I note it appears to be capable of taking the Rapamycin into the blood stream, do you think it too much? https://www.amazon.com/gp/product/B006SW94SI/ref=ox_sc_act_title_1?smid=A4EGE1YRSP1KL&psc=1

Ross Barker Yes I am currently using that cream since the one that i usually get is not available. It seems to working well.. ... here is the link to the one I have been using for the past 7 or 8 months... But the way i can now report that the siromilus topical can visually afffect crepy skin on the inner arms ... maybe to the tune of 40 or 50% improvement. My eyes are much better now that I stopped doing the Retinol treatments.... but I did them for around a month and a half and now my eyes are even better than when I started using it so it definatly helped improve the results of the Topical treatments of Sirolimus. Here is the Cream i used for many months 

• DMSO Cream With Aloe Vera - Lavender Scented, Made With 99.9% Pure Pharmaceutical grade DMSO - 70… $19.95

 Here is the Cream i used for many months 

Michael 

Michael I dunno how to make 'em but I'm good at talking.   a) Ask someone to send you soil sample from the island Rapa Nui and culture the bacteria in petri dishes.    b) Use the info on Wikipedia to synthesize it.   You can probably find the component enzymes and metabolites from a place that sell them.   You can get lab equipment from them too or some other place.   You may run into issues with them not selling you, similarly to restrictions put on Rapamycin itself.    And all this could be very expensive.

c) Or if you're lucky you can find a plant, herb, or an animal that has it.

After you get the pure goods, you may want to go full Breaking Bad.   It may just take a few razor blades (very cheap), and a glass top table or you could be at a lost of how to deliver it into the body effectively without being consumed by the liver or destroyed in the stomach.

Michael it is a topical treatment.... you mix it .... check out my posts and you will find where i am talking with Dr Mark in another section on this forum.. check those posts out and you will learn how to mix it and what do do to make this work. it is all there.... This one works awesome but you need patience.. but there are hints how to enhance the effectiveness...

garland Thank you. Question: Are you concurrently doing the cream and taking in pill form, per a Dr. Green type of schedule? 

Michael see above I just posted how to do it and mix it... 

garland Thank you

garland Just made it as outlined. Seems like an awful waste of rapa as when mixed in four ounces of Arbo Trex Dmso/Aloe Vera cream (an impossible feat if even distribution is the goal), there's likely to be many more days where application is completely devoid of actual rapa than not.

After initial mix, I added and diluted one additional rapa tablet into the mix. 

Mark Thimineur

Michael So you mixed in 4mg into 4 ounces of cream? I know it seems like a weak formula but people are getting results, granted it takes 2-3 months though. Mark points out more is not better and he says just apply it twice a day for faster results. But something still bugs me about it though, it would seem to make more sense having a stronger formula that is applied less often rather than a weak formula more often. But for now, I am using a 3mg per 4 ounce solution and have been for two months.

Fred Cloud I only ended up adding another mg as there was unintended loss after transferring the diluted rapa/dmso into the 4 ounces of Arbo Trex Dmso/Aloe Vera cream. The truth is I wasn't expecting it to arrive so quickly and in my excitement, began following your formula with a make-shift, bob-the-builder set-up. Thanks again for providing that formula above.

I agree with you that less is more- initially for sure. But I also feel much faster results would be obtained with potentially 2 ounces of medium or... something. 

I did want to ask if you've noticed any difference since you've begun applying it twice a day AND beyond this cream, are you also taking rapa in pill or sublingual, and if so, how much weekly?

Thanks again!

Michael I have been taking 3mg rapa weekly and using the topical rapa for 2 months and I havent noticed a difference yet in my skin. But I am not panicking yet because Paul Beauchemin mentioned he didnt notice changes until 3-4 months.

Having said that, it has been life changing to me in terms of my health, I feel completely different and feel about 10 years younger in terms of inflammation and overall age of my body.

Fred Cloud Right on, brother!

It's been a shitful year for me health-wise (outside of losing tons of weight and bodyfat via massive amounts of light, endurance exercise) with Carcinoma. I'm hoping for a like benefit in the skin arena. I'm giving it 3 months then going full bleph. 

#blephbros

Michael  not sure what you mean. I used the DMSO from Heiltropfen from Germany as my medium to absorb the Rapa. I put it into a test tube about one third full and then added the Rapa to it. Remember I first put the Rapa in a motor and pistol and thoroughly ground it up. Then when I put this mixture in the DMSO liquid in the test tube  I then shook it up thoroughly. DMSO is a great absorber of chemicals so it absorbed the Rapa as I could see the mixture get cloudy. I then poured this liquid cloudy mixture into a bowl of the 4 oz DMSO/ALOE cream to mix it up thoroughly. It mixed easily  so I do not feel that this mixture was haphazardly created. I used enough  liquid DMSO mixture to make sure that this product was easy to mix in the Cream DMSO/Aloe.... IS that what you did...

garland I appreciate your formula. I ordered the exact same items. I think I probably just didn't use enough Heiltropfen.  Thank you!

Michael Yea I used alot of it so it would mix well....

Michael You also have to ground up the pills very finely.... makes it easier for the DMSO to absorb it... meaning the liquid DMSO not the Cream..

garland Yes. I bought the mortar which made grinding it down extremely easy. I just didn't use enough liquid DMSO before adding to the cream. I appreciate you!

Fred Cloud Any update on noticeable differences? Thank you.

garland Any update on efectiveness? Thank you

Michael month 3 and not much change, but I did not use dmso. I may add dmso to the mix, it may be needed for deeper dermal layer penetration. Did you start on rapamycin oral or topical?

Fred Cloud Thank you, bro.  I started on the cream - nothing yet. I started 3mg a week of the pill and believe some nasty lung / flem stuff happened from the pill so, probably will discontinue use. On a different note I started up the Kaufman protocol - every stinking pill. Loads of energy!

Michael I followed exactly the recipe posted by Mark Thimineur, but I made a double quantity using three 2mg Sirolimus tablets that I ground up with mortar and pestle. The dissolved sirolimus mixed easily but I think a little more DMSO liquid would have been even better. I took baseline measurement with the skin fold test on one hand and took photos of my cheeks and forehead as well as the sagging skin on my upper arms. I've been applying twice a day for 10 days. I stopped all oral sirolimus since it seemed to interfere with healing of a slow healing wound. I will document and post progress, if any, after a few months.

chuck stanley Thank you, Sir! I look forward to seeing your results.

Fred Cloud My update on this so far is nothing positive - potentially worse as I'm applying in under eye area. Stopped taking rapa - just using rapa cream. 

I've maintained an excellent diet. OMAD. Cut back on Whiskey (Painful). Practically zero carbs and sweets. Back to at least 1000 calories a day combination treadmill/ walking with light weights. Focusing more on core: heavier-side squats.

Looks more and more likely a bleph is in my immediate future. 

David H garland Fred Cloud What do I need to know about Rapacan vis-à-vis it's place in the rapamycin hierarchy?  Specifically, 1mg tablets. Thank you!

@Ross Barker  Your math is off

48 grams equals 1.69315 ounces, not 4 ounces

.0002g is .2mg not 2mg.

Fred Cloud The  first  was  a  typo,  the  bottle states  1.7  oz 48  Grams,  likewise I  added  too  many  "0"s I  Better  edit  my  original  post  OOOO,  it won't allow  me  to  Edit  it, I  added .002 G  Rapa powder to  48  G of Cream or  1.7oz,  I  can't  find  where I  said  4 oz. 

Ross Barker You didnt say 4 ounces. I thought you were using Dr Mark Thimineur 25 micromolar formula of 3mg in 4 ounces cream that he discussed. Where did you get 1.7 ounce formula?

Fred Cloud I took  garland s  interpretation  above  for 4 oz of cream  and  cut it in  half  as I  only had  a 1.7  oz tub  of cream, Look  back  to  2 months ago, he  referenced Dr  Mark who's posts  I cannot find.

I  did find   Mikhail V. Blagosklonny Study which  calls for  Much much more  Rapa  (.72  Gram) and  this  Seems  so  little bit I  put in  this  cream,  I'm  wondering  if  this  Dr Mark  formula  is perhaps  erroring on  the  side  of either  caution,  economy  or both. 

I bought 12 Grams  of  Rapa for  this  and used .002 Gram,  it seems so  slight,  I  guess I'm  looking  for somebody  to  agree with  me so I  can  put  more  in..  

Ross Barker I thought the same thing that the formula was light but Dr Mark quoted a study that showed hair loss at concentrations higher than 17 micromolar. You want autophagy in the skin but you dont want to inhibit mtor too much as there wont be growth and your hair will die and create skin ulcers. Read his posts.

From Dr. Mark

"Just wanted to comment on the topical cream. The concentration of 20mg in 4 ounces will be around 1.8 micro molar (approximate). The recent study of topical rapamycin which found significant benefit for senescent clearing and improved appearance etc used a 0.1 micromolar concentration (approximate). Studies on hair (fur) growth in mice using topical found effectiveness at 0.1 - 1.7 micromolar concentrations. At concentrations above this there was mention of non-healing wounds. Just wanted you to be aware that there may be some unwanted effects at higher concentrations. Reading through the literature I believe what you want to do is influence autophagy more so than inhibit growth. In cell cultures they use about 0.2 micromolar concentrations to influence autophagy. I've been using this concentration (approximate) for a topical (2mg in 4 Oz) for a while and see some marked improvements and feel safe in doing so. You may be fine with the 10X higher concentration but sometimes to much may not be as good. "

https://forum.age-reversal.net/t/63j272?r=k9vdnn

Fred Cloud Well, I  did a  little more research with  this Video, an Australian study doing research  on  Children they used a 0.1%  Mixture  and a 1%  Mixture the later  being almost exactly  what  I mixed  this morning, it  was half way  between Mikhail's Weak and strong mix, so I will  keep  it  and mix  a  weak  one  as  well

https://youtu.be/Q7Li0A6KPYg

Does  anybody know what this  Cream  is Recommended  above?

Qimin You I too have recently started and stumbled upon this page and disappointed to see no updates.

garland Do you have any before and after photos?

Michael plastic surgery will not make you younger, perhaps if u look younger it is enough for you? Old and dead is the same no mater how you look

Michael Funny I was going to write you and suggest that you try out the laser so glad you founds something that worked.  Did you try the laser? Or what worked for you.... I did the laser a few years back seemed to help as well... might get of  the last bit of wrinkles that I do have...

Ross Barker Very True :)

garland Bleph. I'm open to the laser in the future though.

garland I actually did the bleph because my upper eye bags were so bad they kept weighing down on my eyes and making me feel tired during the middle of the day.  Too much good LIVING! But, I also opted for the lower figuring - what the heck - may as well. 

Michael Glad it worked cause you were very frustrated with the slow boat to china approach with the Siromilus cream....I may look into the laser to help get rid of the rest of the wrinkles that are under my eyes...it supposed to last a long time.... i will keep the siromilus though for long term and getting rid of aged cells.....

garland Sounds like a plan.

 I guess chemical peels work well too. Who knows.

Time for a beer!

Michael True, there is no substitute for well-done plastic surgery.  The longer one waits to correct wrinkles and facial sag, the more intensive plastic surgery is required (think deep plane).  I've researched it extensively, but haven't opted yet.  I've begun fraxel laser treatment.  Just completed first of the five treatments.  BTW, it has pretty much taken the place of chemical peels.  

Dorian Gray Missed your response - sorry about that.

Given the past 4 months, how do you like the results of the fraxel treatments?

Thank you

Michael It eliminated or lightened considerably some of the dark spots on my hands and face.  Diminished some of the finer wrinkles, but mild effect on the deeper ones.  No one at work said I looked younger, but rather skin looked good, "fresher".  However, it noticeably improved texture and color and that does add an element of youthfulness to the eye's interpretation.  Just not dramatic by any means.  I spent a lot of time in the sun living in Southern California nearly all my life.  Next month I go in for a final picoway laser to further eliminate a couple spots.  There were two types of treatment, different wavelengths (1550 vs 1927) one to treat pigmentation the other for collagen generation.  Even though I wouldn't call it a vast improvement, I would do it again.  

Dorian Gray Thank you

garland Is this still working for you? Have the results become more noticeable?

Thank you

Michael  yes but the most amazing thing is that the results seem to be mostly permutant. ... It is not perfect but everyone I have talked with who knew me before says i look 15 years younger and my skin is radically different. I have been to doctors who specialize is lasers etc...who have known me before I started this. I have been taking a break from the treatments for the past month.. I do put several other products on my face and eyes as well... Including Hyaluronic Acid. which seems to help make the results more permanent. Remember that makes this unique is that the treatments get rid of senolytic cells which other treatment modalities do not do...

garland Good to hear. Thank you

Jack Black Nice progress!