The "Reprogramming" of Aging Cells
Researchers associated with the company Turn.bio have a new publication that describes the "reprogramming" and rejuvenation of aging cell cultures by infusing them with a "cocktail" of six different messenger RNA types that generate the "reset" proteins OCT4, SOX2, KLF4, c-MYC, LIN28 and NANOG (OSKMLN). The link to the paper is HERE.
They suggest an ex vivo treatment in which stem cells could be removed from a subject along with fat cells, separated and treated externally with the mRNA cocktail to rejuvenate the stem cells, and then re-injecting the treated cells into the subject. In the longer term, they may be investigating an in vivo procedure that might involve encasing the mRNA in lipid nanoparticles, infusing this into the bloodstream, and directly reprogramming cells in a living organism.
-
I've read about this before on Betteraging, and it sounds absolutely insane (in a good way, of course). I'm wondering about the clinical implication though, and ethical issues this may arise. I'll keep following closely
-
According to a new study, published Nature Medicine has found hundreds of blood proteins responsible for determining some signs of aging, providing crucial hints about the substances that can slow aging.
-
Robert Reny
Blood Protiens and Age
The blood protein study done by a Stanford group and published in Nature gives the following twenty blood proteins as those with the highest correlations with calendar age. The "Age Coeff" column gives a relative indication of how strong the correlation is. Positive coefficients mean that those proteins grow in concentration with increasing age, and negative coefficients mean that those proteins decrease in concentration with increasing age. Note that only four of the top twenty are negative.
# Protein Code Age Coeff Name 1 CGA.FSHB.3032.11.2 0.016365884 Follicle stimulating hormone 2 CGA.CGB.4914.10.1 0.010395884 Human Chorionic Gonadotropin 3 MLN.5631.83.3 0.009485893 Promotilin 4 CGA.LHB.2953.31.2 0.008592079 Luteinizing hormone 5 SOST.13101.60.3 0.007350062 Sclerostin 6 NPW.9986.14.3 0.006876421 Neuropeptide W 7 NPPB.7655.11.3 0.006099095 N-terminal pro-BNP 8 ARFIP2.12630.8.3 0.005608723 Arfaptin-2 9 RNASE1.7211.2.3 0.005343526 Ribonuclease pancreatic 10 MSMP.8080.24.3 -0.005261223 Prostate-associated microseminoprotein 11 GDF15.4374.45.2 0.005258380 Growth/differentiation factor 15 12 PPY.4588.1.2 0.005207346 Pancreatic hormone 13 CHI3L1.11104.13.3 0.005061734 Chitinase-3-like protein 1 14 RET.3220.40.2 -0.004679486 Proto-oncogene tyrosine-protein kinase receptor Ret 15 COL11A2.11278.4.3 -0.004193358 Collagen alpha-2(XI) chain 16 PRSS2.5034.79.1 0.004159952 Trypsin-2 17 CHIT1.3600.2.3 0.004046979 Chitotriosidase-1 18 CDSN.7085.81.3 0.003910699 Corneodesmosin 19 HAVCR1.9021.1.3 0.003879657 Hepatitis A virus cellular receptor 1 20 MBL2.3000.66.1 -0.003719320 Mannose-binding protein C
-
-
Probably why so many drugs and supplements show evidence of minor life extension.
-
Several studies have found that transfusing blood from young mice to older ones could reverse some signs of aging. Until a few days, it was unclear what component in the blood leads to such a significant effect. But according to new study hundreds of blood proteins responsible for determining some signs of aging.
-
Robert Reny Here is another comment on this interesting research.
https://www.leafscience.org/blood-proteins-can-show-how-old-you-really-are/
-
