metformin negative study
I'm 61 and stopped taking metformin after reading this study:
"Age is decisive for positive or negative effects of the diabetes drug metformin"
https://medicalxpress.com/news/2020-11-age-decisive-positive-negative-effects.html
The study showed in c. elegans, that metformin was good when introduced while young, but toxic when introduced to c elegans in old age, concluding ""Our data raises serious questions about the suitability of metformin as an anti-aging drug for older individuals without diabetes"
Has anyone heard a good reason to dismiss this study and start taking metformin in old age?
Thanks
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Towards the end of the article it says:
"Rapamycin alleviates metformin toxicity"Using proteome and lipid metabolism analysis, the team showed that metformin treatment initiated at an advanced age induces a cascade of metabolic failures culminating in lethal mitochondrial decline, exhaustion of ATP and ultimately in cell death. Interestingly, the toxic effect of metformin in old animals was reduced by simultaneous administration of rapamycin, an immunosuppressive drug found by the authors to stabilize the ATP levels in metformin-treated cells—a possibility to alleviate metformin toxicity in older organisms and advance the idea of metformin as an anti-aging drug."
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Recent mouse and rat studies indicate still a positive benefit and it synergizes with rapamycin:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013015/ (ITP study that covers a several compounds) &
https://www.hindawi.com/journals/omcl/2019/3428543/ &
https://www.liebertpub.com/doi/abs/10.1089/rej.2016.1826?journalCode=rej
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Aren’t there human studies that would outweigh a single worm study?
