32 years old. Is self-experimentation right for me?

Hi Sara,

Good work on your lifestyle, this is more than most do!

I'm 38. In my opnion, starting early may be the best thing we can do for ourselves. Firstly because milder, less expensive things may suffice, secondly because I think the perfect order of treatment may be less important when there is less damage and senescence in the body. That said, there are risks I'd take at 78 that I would not take today. I do take a tiny bit of rapamycin but instead of dasatinib I use LE senolytic activator with Theaflavins. So I self experiment, intervening in the same processes with milder inputs than an aged person would.

Self experimenting is highly personal, and only you can decide what is right for you.

Strongly agree with Dan. At your age, concentrate on healthy lifestyle.  You are fortunate to have time to wait for more research to get done.

I started in my early 30s. I think it's the best time because that is when you begin to age. 20s might be early, but by your 30s, you need to exercise to actively avoid muscle loss, so it's not too early. 

The biggest thing is to realize that you don't need to hit things as hard, but as you age, you may need to add more things to your regimen. The great news is that there will be more/better information as you age. Fisetin didn't become known as a senolytic until I was 38!

I would begin with a nicotinamide riboside supplement, as this begins to decline in your early 30s. I use Ellysium. I would make sure you get lots of colorful fruits and veggies in your diet. You can add some vitamin/polyphenol supplements if you think you are low or want a boost. Biotivia Pteromax was my favorite polyphenol supplement in my early 30s. I also took Mitoq, but don't currently. I have added Jarrow Broccomax for more sulphoraphane because its pretty cheap but effective, and I don't want to deal with growing and eating a ton of broccoli sprouts. I also supplement with omega-3 fish oil to make sure I get plenty as I don't eat a lot of salmon or trout.

As for senolytics, I would start with fisetin. It's showing to be effective, and easier to get than dasanitib. I currently do 20mg/kg for 2 consecutive days every 2 weeks because I notice fine lines creeping back at that point. In your early 30s, you would probably be fine doing it monthly. 

Also, look up "facerobics" on youtube. Even with all the anti-aging science, getting face muscles moving does a lot! Ironically, she does hers when she first wakes up in bed- guess what? Exercise without the immediate presence of protein induces apoptosis of senescent cells, but does not induce as much hypertrophy (muscle enlargement). So she is not only preventing sagging, but also getting rid of some senescent cells in her face as well! (And she doesn't even know it!) I would also look at other face programs to customize to a look you want, but hers is the most impressive I have seen for free on youtube, and even more impressive than a lot of other paid programs. You may want to try this out now, but it will come in most handy in your later 30s.

But just remember, while it's nice to look young, it's sometimes embarrassing to have college guys try to pick up on you at the university gym when you know you are old enough to be their mom! (My husband is a professor, and we work out on his lunch breaks.)