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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392256/
At the FDA, scientists are investigating many drugs that function through epigenetic mechanisms (although as spokes-woman Christine Parker notes, the agency bases its approvals on results of clinical trials, not consideration of the mechanism by which a drug works). One such drug, azacitidine, has been approved for use in the United States to treat myelodysplastic syndrome, a blood disease that can progress to leukemia. The drug turns on genes that had been shut off by methylation. The drug’s epigenetic function doesn’t make it a “miracle drug,” however. Trials indicate it benefits only 15% of those who take it, and a high percentage of people suffer serious side effects, including nausea (71%), anemia (70%), vomiting (54%), and fever (52%).
Ehrlich points out that azacitidine also has effects at the molecular level—such as inhibiting DNA replication and apoptosis—that may be part of its therapeutic benefits. The drug’s mixed results might also be explained in part by a study published in the October 2004 issue of Cancer Cell by Andrew Feinberg, director of the Johns Hopkins University Center for Epigenetics in Common Human Disease, and his colleagues. They found that each of two tested drugs, trichostatin A and 5-aza-2′-deoxycytidine (which is related to azacitidine), can turn on hundreds of genes while also turning off hundreds of others. If that finding holds in other studies, it suggests one key reason why it is so difficult to create a drug that doesn’t cause unintended side effects.
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https://www.activemotif.com/blog-reversing-epigenetic-age
Epigenetic Aging Reversal Clinical Trial Design
The treatment cocktail used in the clinical trial included recombinant human growth hormone (rhGH) to reverse or slow down the immunosenescence, and two other diabetes drugs, DHEA and metformin, to counter some unwanted side effects that could be caused by increased insulin production as a result of the rhGH treatment.
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Andrew P K Yap
TMG Trimethylglycine is known for its effects on methylation and Homocysteine levels.
Alpha-Ketoglutarate is another substance they some claim to have a profound effect and can reverse methylation to a younger state:
Rejuvant is selling variation of AKG. Calcium Alpha-Ketoglutarate
https://www.longevity.technology/rejuvant-shows-positive-early-results-in-humans/
There are other forms of Alpha-Ketoglutarate, Arginine Alpha-Ketoglutarate, Creatine Alpha-Ketoglutarate, Glutamine Alpha-Ketoglutarate, L-Leucine Alpha-Ketoglutarate, Taurine Alpha-Ketoglutarate,
I have almost only seen research done on Arginine Alpha-Ketoglutarate and Alpha-Ketoglutarate. And now Calcium AKG.
When it comes to the study with human growth hormone (HGH), Dhea and Metformin I read this nice discussion. It is hopeful but the duscussion ends with reluctance to implement the result in anti aging regimes, at least at this point.
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Staffan Olsson
Thanks to you I am now acquainted with:
TMG Trimethylglycine
and
Alpha-Ketoglutarate
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this study cut epigenetic age in half
https://joshmitteldorf.scienceblog.com/2020/05/11/age-reduction-breakthrough/
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From the scientists:
We have two separate products: one is a very powrrful anti aging molecule already tested on Harold with amazing effect (all his aging spots from his arms disappeared in a week). This product we wish to sell as a topical gel and transdermal patch. The gel will fall under cosmetic category with FDA so may be out early. Patch needs a FDA clearance so may take longer.
Apart from this is our flagship product code named Elixir which would be administered as injections or IV. The paper listed here by Josh is on Elixir results. I hope this clears the confusion. Good news for all of us anti-agers is that both the products should be affordable. -
Paul Beauchemin Paul Beauchemin I’ve read Josh’s post. Could be the beginning of the end to aging. The fact that Dr Horvath signed onto this study tells me this is a game changer.
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Larry
A link to the paper.
https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1
this is very exciting. The results are spectacular. Almost as fascinating as the famous C60 study.
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Do the the rats receiving the elixir treatment live longer?
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QUESTION:
While the ages estimated by epigenetic clocks often correlate very well with chronological age, it is not clear whether the DNA methylation profiles in the clocks directly contribute to the aging process.
Does anybody know of any study that answers this question, whether DNA methylation clocks contributes to the aging process? That is to say, you age because of the DNA methylation. If the answer is yes, then I suppose demethylation will result in aging reversal.
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The clock isn't a single thing, but a statistical analysis of epigenetic changes associated with aging. So when they say the clock was reversed, they mean the epigenetic changes were reversed. When these epigenetic changes are reverse to an extreme, the cell reverts back into a stem cell. So it's very literally reversing the age of the cell, possibly all the way to its inception, if not controlled.
