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Re: How to increase the bioavailability of Fisetin
@wzis I believe the science, but I'm not convinced that the lab experiments with mice translate to similarly benefits for humans.
- Robert_Uomini
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@Joe F That was my theory, too, but so far, I haven't seen any effect. In my case, I used a syringe to inject the fisetin-oil mixture. I'll try again every week until my stash is used up.
- Robert_Uomini
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@wzis I really, really wanted to see some effect, but didn't (except for the drain on my wallet 😣). I dissolved 500 mg of fisetin in a little olive oil and took it daily for several months (added…
- Robert_Uomini
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Can snorting fisetin improve bioavailability and is it safe?
@JGC Thanks a lot for the link. I just watched the first 42 minutes and plan to continue to the Q&A later today, but I did notice that Kirkland mentioned that he advises us "amateurs" (not his word)…
- Robert_Uomini
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Has anyone tried taking fietin as a suppository?
@Staffan Olsson Did you notice any cognitive improvement, e.g., improvement in working memory? I wrote an Android app to test working memory (Krazy Keyboard, https://play.google.…
- Robert_Uomini
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Can snorting fisetin improve bioavailability and is it safe?
@JGC I'm using the same study and converted the 100mg/kg dosage for mice to a human dosage of 8.13 mg per kg of weight.
- Robert_Uomini
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Can snorting fisetin improve bioavailability and is it safe?
@Dan Nave In fact, i never did start snorting the stuff. I did, however, recently start taking it as a suppository. My capsules are 250 mg each, 98 per cent fisetin, so I'm taking two per day.
- Robert_Uomini
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Can snorting fisetin improve bioavailability and is it safe?
@JGC Where does your protocol come from? Mine comes from a mouse study that, when scaled up to human weight, calls for 500 mg per day for a month.
- Robert_Uomini
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Can snorting fisetin improve bioavailability and is it safe?
@JGC I had researched the bioavailability of fisetin when used with Piperine, but I found nothing, although I did see that bioavailability of certain other flavenoids, especially curcumin,…
- Robert_Uomini
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Can snorting fisetin improve bioavailability and is it safe?
@JGC I take 500 mg per day of fisetin. Since the stuff is so expensive here in France (I pay 84 euros for 60 250 mg capsules), taking more than that would cause me to use up my one-month supply in a…
- Robert_Uomini
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Can snorting fisetin improve bioavailability and is it safe?
I had researched the bioavailability of fisetin when used with Piperine, but I found nothing, although I did see that bioavailability of certain other flavenoids, especially curcumin, was increased.…
- Robert_Uomini
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Can snorting fisetin improve bioavailability and is it safe?
@Fred Cloud I don't understand how you're getting ANY results by taking fisetin orally, since it's well known that stomach acids and the GI tract in general prevent fisetin from entering the…
- Robert_Uomini
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Has anyone tried taking fietin as a suppository?

I would think that, by bypassing the GI tract, this would guarantee 100% absorption into the blood.
- Robert_Uomini
- 4 yrs ago
- 5replies
- 308
- Senolytics Discussion
Can snorting fisetin improve bioavailability and is it safe?

Title says it all. I suspect that since fisetin is hydrophobic, it won't dissolve in the body and would only serve to irritate the lungs, but I'm not a pulmonary expert.
- Robert_Uomini
- 4 yrs ago
- 16replies
- 252
- Senolytics Discussion
Re: How to increase the bioavailability of Fisetin
@Joe F The miracle fruit? That would really be a miracle!
- Robert_Uomini
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
Now that I think about it, since fisetin is fat soluble, it would make sense to dissolve it in, say, some olive oil and put that under the tongue. It would absorb faster than just using the dry…
- Robert_Uomini
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@Ajax Regarding the taste of fisetin when placed sublingually, if you take a miracle fruit tablet first and let it dissolve under the tongue, it seems to dial down the fisetin taste.…
- Robert_Uomini
- 4 yrs ago
- Self-Experimentation
- Reported - view

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