Is metform safe to take for non-diabetics?

Is it confirmed already that it's safe to take for non-diabetics or are we still trying to figure this out (e.g. with clinical trials)?

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  • The assumption of many people is that it is safe for non diabetics because it is considered safe for millions of diabetics. Some disagree with that view. During my research, I haven’t found any human studies for the off label use of metformin as an anti-aging drug. There is a funded study which will start soon. Look at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943638/

    Life Extension has recommended metformin as an anti-aging drug since about 1995.  Dr. Sandra Kaufmann, MD, recommends it for non-diabetics in her book, The Kaufmann Protocol. David Sinclair (Harvard Antiaging researcher and author of the book Lifespan) who has tested metformin in mice studies, personally uses metformin as a non-diabetic (but it seems he doesn’t take it everyday).  I believe it is safe enough for me so I started taking metformin in October 2019. I bought it over the counter in Asia.

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  • "Is it safe" is not really the correct question to ask.  The better question is "do the benefits outweigh the risks?"  The answer depends on a lot of personal factors.

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