Rapamycin and shingles, is there a connection
I have a question about the effects of rapamycin and whether it may play a part in my attack of shingles. I am 53 and have been self experimenting with 6mg a day augmented with grapefruit juice for 6 months. This is the first attack of shingles I had had and I wonder if I am inhibiting my immune system too much. I also take an anti TNF drug for a rheumatological condition. Any thoughts much appreciated?
If I'm reading your post the right way it does look like you are taking immunosuppressive doses, which is not good if you are looking for therapeutic/longevity results. For example, the Mayo Clinic lists Sirolimus (Rapamycin) to prevent kidney rejection, to be dosed at 2 mg a day for adults, after an initial first dose of 6 mg. Others are put on 5 mg a day after an initial large dose.
Grapefruit is compounding the problem by increasing one's serum level to ~350%, according to Cohen et al. "Phase I Studies of Sirolimus Alone or in Combination with Pharmacokinetic Modulators in Advanced Cancer Patients " (2012).
In the PEARL trial the cohorts are taking either 5mg once a week or 10mg once a week of rapamycin, for one year. That's a far cry from your 6mg per day.
Together with grapefruit the effective dose can go up to around 21 mg = 6 mg * 3.5 (grapefruit effect on effective dose). So it is very high dose and can probably create different side effects.
On this post you can see some common longevity dose regimes out there.