Intermittent doxycycline and life extension in mice

Mice given doxycycline, an antibiotic, intermittently lived about 30% longer.  Has anyone looked into this?  I just took a round of doxycycline due to an injury, but was wondering if this will make me live longer.  Supposedly there is some sort of regeneration in cells of tissues.  The mechanism of life extension could be mitohormesis.  Here is the study:


https://www.cell.com/fulltext/S0092-8674(16)31664-6

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  • Doxy also has some anti-cancer effects. It maybe a reasonable idea to take it  intermittently like a senolytic or an anti-cancer drug. One worry is nuking your gut microbiome. Repeated antibiotics are harmful when you're growing up. Not sure about anti-aging. 

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  • Can anyone convert this mouse dosage to human dosage?

    "Induction of OSKM was performed by administration of doxycycline (1 mg/ml) (Sigma) in the drinking water. The in vivo cyclic induction protocol consisted of 2 days of doxycycline administration followed by 5 days of doxycycline withdrawal. For lifespan experiments, cyclic doxycycline administration started at 8 weeks of age and continued until death."

    It doesn't say how much the mice drank in the study...

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    • Jimmy2 

      Without knowing how much they drank it is not possible (or at least very difficult/speculative) to estimate human equivalent dose (HED).

       

      Here is  a  paper about basic dose conversions between animals and humans.

       

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804402/

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