Antioxidants and Dasatinib regimen
In the protocol from the Faloon presentation it was recommended to stop antioxidants 1-2 weeks prior. What is the rationalization there?
It was also recommended to stop aspirin for a week but that makes some sense as dasatinib seems to sometimes cause problems with bleeding.
There is research showing that some senolytic substances works through ROS activated apoptosis. But here are also pathways to senolysis that are ROS independent.
In some research they have used N-acetylcysteine (an antioxidant) and the result has been that N acetyl cysteine in some cases have inhibited the actions of the senolytic substance. Or at least reduced it.
I think that is why they recommend to stay away from antioxidant supplements before a senolytic treatment.