Weekly Rapamycin/Sirolimus Therapy and Diarrhea?

Sirolimus is used with other medications to prevent rejection of a kidney transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own.

I don't know anything about this drug but just looked it up.

Diarrhea is good because your body is trying to get rid of "poison", either something it deems poisonous or bacteria.   Because your immune system is weakened, then innate immunity has to kick in (I consider diarrhea a type of innate immunity).   If you think this drug is beneficial, maybe accept the side effect?

Or it could be simple as somehow this medication reduce your stomach acid production.    In this case the remedy could be (the night before) take an acid supplement pill and also use digestive enzymes with your meal.   Eat an easily digest meal.

Low acid production is part of growing old and your system is in a delicate balance.   The drug just push it beyond the threshold.

I’m experiencing either mild diarrhea or soft stool. I was blaming the coffee. the worst effect I’m experiencing is an acne outbreak on my face and scalp, but only limited to my head. I’m currently taking 6mg/week,but I’ll go lower, to 5mg/week and see what happens

I'm 61 and just started with a weekly dose of 3x2mg of Sirolimus for anti-aging purposes. Expensive stuff! So far, so good, no side effect whatsoever except for great hopes and some skepticism. I'll keep you posted.

I also experienced the "runs" from weekly dosing of Rapamycin/Sirolimus and even after lowering my dosage to only 2mg/week.  After reading a study on the use of 2 grams/day of ginger powder to alleviate colitis, I added 2 grams of ginger powder twice per day (4 grams/day total) for two weeks and found that now I can handle 6mg/week of Sirolimus WITHOUT the diarrhea problem and with a very noticeable improvement in my gut function. See the article here: https://www.sciencedirect.com/science/article/abs/pii/S0965229918310008?via%3Dihub

You can get a whole pound of organic ground ginger powder on Amazon for less than $10.