If you want to use HGH for thymus regeneration, the peptide Ipamorelin is a better option I believe

Ipamorelin is a peptide selective agonist of the ghrelin/growth hormone secretagogue receptor and a growth hormone secretagogue.

Ipamorelin does not cause increases in corisol and prolactin like other ghrps such as ghrp-2 and ghrp-6.

Higher doses of Ipamorelin 1mg + release much more HGH than lower doses.

You can take a larger dose every 6 hours. How much growth hormone is needed to regenerate the thymus? I dont know. Is more better?

The problem with using exogenous HGH is that is shut down your natural production of hgh and has other side effects like increased prolactin. Ipamorelin causes your the anterior pituitary gland to release its own stores of HGH and does not cause a down regulation of production or release long term.

With HGH usage or ipamorelin usage you can become more insulin resistant so this is something to look out for.

Perhaps doing a few cycles a year of ipamorelin would be a good strategy.

Using ipamorelin also makes your skin look nicer. I have been using it on and off for about 10 years now.


MH Rasmussen, B Soogaar, L YnddaI, L Groes, L Helmgaard, L Nordholm. Novo Nordisk A/S, Clinical Development, Bagsvaerd, Denmark.

In a randomized, double-blind, placebo-controlled, parallel group, dose-escalation, single-dose trial the pharmacokinetics and the growth hormone (GH) release of ipamorelin a novel pentapeptide GH secretagogue was investigated. Eight healthy male volunteers (6 active, 2 placebo) on each of five dose levels received trial product as a 15 min i.v. infusion. Dose level 1-5: 0.003, 0.01, 0.03, 0.06, 0.1 mg/kg, respectively.

A 10-h plasma profile of ipamorelin was determined for dose level 1-3 and a 24-h plasma profile was determined for dose level 4 and 5. A 10- h plasma profile of GH release was determined for all dose levels. No serious adverse events were reported and none of the subjects withdrew due to an adverse event.

Cmax and AUC for ipamorelin increased with increasing dose ranging from 30-809 nmol/l, and 68-1823 nmol*h/l, respectively. The elimination half-life ranged from 2.4 to 3.1 h for the three lowest dose levels and was 6.4 and 5.5 h for dose level 4 and 5.

At high dose Ipamorelin continues to remain active for 5 to more then 6 hours. This means a dose of about 4mgs will result in Ipamorelin in plasma exerting an effect for 5 or so hours.

Substantial GH release.

Although linearity between ipamorelin and GH with respect to AUC and Cmax was demonstrated, the maximum concentration of GH was reached in the 0.06 mg/kg dose level, indicating 0.06 mg/kg as the highest effective dose. In conclusion, ipamorelin is able to induce a massive GH release in healthy male subjects.

So the maximum effective Ipamorelin dose (sans GHRH) is  about 0.06 mg/kg

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    • Michael
    • Michael.1
    • 2 yrs ago
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    Typically, at 50+ years old, we're not producing any natural GH to speak of so, shutting it down isn't a concern.  Also, I'm pretty certain Dr. Fahy would have settled on a peptide rather than GH, if he thought it would better help accomplish his goals.

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    • Michael Agreed. Ipamorelin hasn't shown efficacy in increasing GH to youthful levels and is highly variable in large populations. 

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