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FOXO4 is a gene part of the FOXO group - FOXO3 is a famous longevity gene. Before any experimenting I'd suggest consulting your genetic test to see how you come out on that (I've got CT). If you have one or more of the T variants (IIRC) that is strongly associated with longevity, from many studies. In practice this means that the T variant encodes an enzyme differently than the base version. I don't know what you mean by supplement, are people taking the enzyme directly?
If so, then armchair hypothesizing, if you already have a CT or TT then why would you mess with the enzyme? If you're CC, well maybe you could take it, but would it help? You're already producing the CC variant yourself, unclear to me if adding in the CT or TT version (if it's even available??) would do anything, not to mention possible side effects or efficacy.
Dubious of this one.