AB263 Navitoclax

This is very interesting 

https://www.adooq.com/abt-263-navitoclax.html

The 10ml dosing is in 1ml of DMSO, taken orally. 

We need to look at this further!

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    • BobM
    • BobM
    • 5 yrs ago
    • Reported - view

    Sorry: it’s ABT263

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    • cacarr
    • cacarr
    • 5 yrs ago
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    One would want to be extremely careful with Navitoclax as it could cause thrombocytopenia.

    Another exciting possible application of that compound is as a general anti-fibrotic. It induces apoptosis in persistent myofibroblasts, and has been shown to actually reverse fibrosis in a model of scleroderma:

    https://medicalxpress.com/news/2017-12-drug-apoptosis-myofibroblasts-fibrosis-scleroderma.html

    Diseases it might work against include scleroderma, Dupuytren's contracture, Peyronie's, etc ... and by far most important, Idiopathic Pulmonary Fibrosis, which is a maddeningly tricky disease to treat, and quite deadly.   

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