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Re: Fisetin to Clear Senescent Cells
Here’s an interesting discussion on senolytics. Seems it could be harmful if taken without something to replace cells that are removed also interesting that UBX0101 failed in part because of very…
- Paul_Beauchemin
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin?
@Joe smith https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3765582/
- Paul_Beauchemin
- 4 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin?
@Joe smith https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594297/
- Paul_Beauchemin
- 4 yrs ago
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin?
@Peter H. Howe a brilliant personal attack!
- Paul_Beauchemin
- 4 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Glucosamine instead of Metformin and Rapamycin?
@Joe smith very strange. I take 10 mg a week and am an avid hiker and mountain biker. Ramamycin has no effect at all on my workouts
- Paul_Beauchemin
- 4 yrs ago
- AMPK Activation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Peter H. Howe Q.E.D. No evidence to support any of the claims is substantiated. My point has never been about whether or not fisetin will or won't be an effective anti-aging supplement.…
- Paul_Beauchemin
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Peter H. Howe so no effect on T nor age markers. The mind is quite powerful. I can use hypnosis to get you to double your chin ups! still skeptical about senolytics since no real life extension…
- Paul_Beauchemin
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Paul's self experiment II

My original thread was hi-jacked so starting another Still taking rapamycin. Experimented with GDF11 and will take blood tests in Jan to see if it has had an effect Looking into peptides.…
- Paul_Beauchemin
- 4 yrs ago
- 2replies
- 304
- 1
- Self-Experimentation
Re: Rapamycin Cost
@Fred Cloud look into growth hormone releasing peptides - less expensive and safer
- Paul_Beauchemin
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Fred Cloud Peptides seem like a very interesting area to explore. I don't know how to create a whole new category on the home page, but I hope a moderator can do it so a discussion can develop.…
- Paul_Beauchemin
- 4 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Fred Cloud this paper doesn't claim that taking a senolytic raises testosterone
- Paul_Beauchemin
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
so, if someone claims testosterone is increased via fisetin, take a blood test and show results. Guessing is for the artists, not the scientists
- Paul_Beauchemin
- 4 yrs ago
- 2
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
I'm skeptical that taking a round of fisetin helps doing more pushups. A senolytic is killing off a few senescent cells. Probably should reduce inflammation markers over time.…
- Paul_Beauchemin
- 4 yrs ago
- 2
- Senolytics Discussion
- Reported - view
Re: Would be nice if I could actually buy rapamycin
@Peter H. Howe i do take fish oil - about a gram a day when these labs were taken. I have doubled that since then as evidence seems to show a significant anti-inflammatory effect
- Paul_Beauchemin
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Dean W. yes, the mind is very powerful. I discount all the anecdotes about feeling stronger, more alert, more energy as purely placebo. Give me several blood tests that show an improvement before…
- Paul_Beauchemin
- 4 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Would be nice if I could actually buy rapamycin
@Ross Barker no changes in diet between these two lab tests Wouldn't take statins again - took for years and caused severe muscle pain. Think the science on their effect is pretty thin now
- Paul_Beauchemin
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Would be nice if I could actually buy rapamycin
@Ross Barker here are my labs rapamycin no rapamycin Cholestrerol, Total 241 256 Cholesterol/HDL raito 3.3 3.3 LDL 147 169 HDL 72 71 Triglyceride 109 81
- Paul_Beauchemin
- 4 yrs ago
- 4
- Rapamycin Discussion
- Reported - view
Re: How much autophagy with rapamycin
@Brin Chikovski not realistic - we are not being genetically modified when fasting or exercising
- Paul_Beauchemin
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"?
@Brin Chikovski reaction time: https://humanbenchmark.com/ grip strength: https://www.amazon.com/gp/product/B00A8K4L84/ref=ppx_yo_dt_b_search_asin_title?ie=UTF8&psc=1 PEF/FEV: https://www.amazon.…
- Paul_Beauchemin
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Would be nice if I could actually buy rapamycin
@Ross Barker bought 500
- Paul_Beauchemin
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Would be nice if I could actually buy rapamycin
@Bernie great price! Thought I was getting a deal from dropshipmd at $1.67/mg
- Paul_Beauchemin
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Tracking progress of my experiment
@Michael those attributes are mostly influenced by the placebo effect. Not useful for a scientific mind
- Paul_Beauchemin
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"?
@Ross Barker year and a half
- Paul_Beauchemin
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"?
Yes, I always discount stories about someone feeling better, claiming better mental acuity or improved mood. my personal testing regime life extension comprehension male panel every 6 months…
- Paul_Beauchemin
- 4 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: DNA Methylation Testing Recommendations Sought
@Peter H. Howe 53 vs 52.6
- Paul_Beauchemin
- 4 yrs ago
- Assessing Biological Age
- Reported - view

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