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Re: Are these issues related to rapamycin @Dr Sian Klerk Up to now, rapamycin and rapalogs are the most well studied mTOR inhibitors and they are now clinically used as cancer treatments. However,…
- Spasov
- Spasov
- 5 mths ago
- 1
- Self-Experimentation
- Reported - view
Re: An alternative criterion for evaluating a senolytic. @Michael Yes, although I don't feel any direct action. I continue because of the statistical studies on the relationship between its concentration in drinking water and average life expectancy.…
- Spasov
- Spasov
- 6 mths ago
- 1
- Self-Experimentation
- Reported - view
Re: My 80 year old father's proposed regimen. What do you think? Sorry for the ridiculous translation! Metformin and Rapamycin work great together. They each have side effects, some of which are eliminated when both drugs are used at the same time.
- Spasov
- Spasov
- 6 mths ago
- Self-Experimentation
- Reported - view
Re: My 80 year old father's proposed regimen. What do you think? Метформин понижава нивата на холестерола. По-нисък холестерол може да доведе до по-ниски нива на някои хормони. Този ефект е слаб и не се среща при много лица, защото това зависи от други фактори,…
- Spasov
- Spasov
- 6 mths ago
- Self-Experimentation
- Reported - view
Re: An alternative criterion for evaluating a senolytic. @Майкъл Да, въпреки че не чувствам никакви преки действия. Въпреки това го продължавам заради статистическите проучвания за връзката между концентрацията му в питейната вода и средната…
- Spasov
- Spasov
- 6 mths ago
- Self-Experimentation
- Reported - view
Re: Protocol which makes senescent cells start to function and hair to grow Това е много интересно :) Мога ли да ви помоля да споделите тук, моля? Благодарим ви!
- Spasov
- Spasov
- 9 mths ago
- Self-Experimentation
- Reported - view
Re: blood work According to traditional medical dogma, smoking is the worst enemy of mankind. But the story is full of examples of drastic changes in medical recommendations.…
- Spasov
- Spasov
- 11 mths ago
- 1
- Self-Experimentation
- Reported - view
Re: Self Administered Anesthetic Dental Injections I found it interesting ... when are such practices used and for what purpose?
- Spasov
- Spasov
- 11 mths ago
- Self-Experimentation
- Reported - view
Re: Longevity Achieved @Juan Daw He is now only 15 years old ... He will share when he grows up :)
- Spasov
- Spasov
- 11 mths ago
- 1
- Self-Experimentation
- Reported - view
Re: Testosterone Trials Testosterone improves many aspects of quality of life in men. From my personal experience, I can definitely say that nothing else has had a more serious positive impact on me.…
- Spasov
- Spasov
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin and muscle mass Chronic mTORC1 activation in old muscle, leads to muscle atrophy mainly due to inability to induce autophagy. Moreover, the hyperphosphorylation of mTOR might lead to resistance to anabolic stimuli…
- Spasov
- Spasov
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: Biohackers Perform First Plasma Dilution Experiment on Humans This technique is a human modification of the Conboys' mouse experiments. @CK I sincerely hope everything goes well with you! However, be careful and monitor your condition. Hyperbaric oxygen therapy provides short-term benefits.…
- Spasov
- Spasov
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Rapamycin - progress so far @Peter Jenkins If you have a friend in Turkey, he can send you Rapamune. I am from Bulgaria and here you can not do without a prescription, and they send it to me from there.…
- Spasov
- Spasov
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: 'Mandated Gov Vax or get fired' I'm one of them. Which one is the least toxic in the long run to our longevity path..? Thanks I think that administering covid vaccines before they were sufficiently tested was a mistake. This will compromise trust in real vaccines, and in years to come, this mistrust will take many victims.…
- Spasov
- Spasov
- 1 yr ago
- 1
- General Discussion
- Reported - view
Re: 'Mandated Gov Vax or get fired' I'm one of them. Which one is the least toxic in the long run to our longevity path..? Thanks Rapamycin seems to be a candidate for COVID-19 therapy . It is also likely that its effectiveness will not be reduced by the high rate of viral RNA mutation.
- Spasov
- Spasov
- 1 yr ago
- 1
- General Discussion
- Reported - view
Re: Rapamycin - progress so far Rapamycin can reduce body fat, but there are more suitable means for this purpose. I agree with Michael.
- Spasov
- Spasov
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Help: Drastic results on DNA biological age test This type of test cannot be relied on yet. Their scientific basis is correct, but the test may be completely compromised by the methodology and the performer.…
- Spasov
- Spasov
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: is pevonedistat an unknown novel anti-aging drug? The author mentions that there was another drug. I wonder what it was? Pevonedistat blocks DNA repair and I do not expect it to cause the effects described.
- Spasov
- Spasov
- 1 yr ago
- Senolytics Discussion
- Reported - view
Re: Azithromycin (Zithromax) as senolytic; a note of caution I tried this combination 3 days ago. I developed my own 7-day protocol, but unfortunately I had to interrupt it on the second day :( The cause was severe low back and chest pain,…
- Spasov
- Spasov
- 1 yr ago
- Senolytics Discussion
- Reported - view
Re: is pevonedistat an unknown novel anti-aging drug? Hello! Sharing this type of information is very valuable to the community. I have a theory that I call the microtumor theory of aging. I think that the new anti-tumor therapies are the way to the…
- Spasov
- Spasov
- 1 yr ago
- Senolytics Discussion
- Reported - view
Re: Anyone actually experience marked increased energy from NMN? It had no effect on me ... Maybe humans and mice are not exactly the same :)
- Spasov
- Spasov
- 1 yr ago
- 2
- Self-Experimentation
- Reported - view
Re: TRIIM study results are in @Fred Cloud Thanks Fred! 3 UI daily. I think GH is a very powerful but temporary doping. After I stopped it, my physical indicators returned to the previous state.…
- Spasov
- Spasov
- 1 yr ago
- Thymus Regeneration
- Reported - view
Re: TRIIM study results are in I used growth hormone for a year. There were many positive effects and they were completely measurable. But things didn't go well for me. I got a mitral valve prolapse .…
- Spasov
- Spasov
- 1 yr ago
- 1
- Thymus Regeneration
- Reported - view
Re: An alternative criterion for evaluating a senolytic. Hello Fred! Like you, I did not expect imatinib to be a senolytic. I started using it for rheumatic pains. I had read many articles about tyrosine kinase inhibitors and nowhere in them did I claim…
- Spasov
- Spasov
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: An alternative criterion for evaluating a senolytic. @JGC I completely agree with you and intend to do so soon. I'm sorry that I haven't done such a test so far and I won't have a base before / after.
- Spasov
- Spasov
- 1 yr ago
- Self-Experimentation
- Reported - view

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