Possible negative response to oral NAD+
My wife and I (~50) have started a NAD+ regime in addition to rest of the other life long regime (vegan, exercise, other suppls). We started with 250mg (sourced from Life Extension), and after reading research from Elysium Health we upped the dosage to 2x250mg in the morning.
We both experienced the usual effects, namely deep sleep/dreaming, but after some weeks my wife started to have negative effects. Started with her legs, a feeling she couldn't describe, but was something like 'restless leg' syndrome kind of thing it sounded like. Then she started to get more and more agitated, and while out shopping almost fainted on getting out of the car on at least two occasions. Suspecting the NAD+ she discontinued taking it and immediately went back to normal. I haven't had any negative effects, but she does tend to be more sensitive to foods/supplements/etc than is generally the case.
This isn't proof of anything, and we're considering having her start up again but at the 1x250mg dosage and seeing how it goes. Searching the web brings up precious little, there is a discussion forum where some people talk about this possibility due to 'over methylation'. Just a post by somebody so no backup on this, but I'm posting here to see if anybody has any thoughts on this.
If not already doing so, I would add magnesium and vitamin D3 to your regimen. My wife too seems to be sensitive. She gets mild headaches and feels tired soon after taking her supplements. Since I added carnosine and benfotiamine to her supplements, she seems to be doing a lot better. We take NAD, jiaogulan, PQQ, benfotiamine, carnosine, methylene blue, Ashwagandha, astragalus, Senolytic Activator, rapamycin, metformin, vinpocetine, pterostilbene, ubiquinol, Magtein, etc.
Dan, the more I've looked into increasing NAD+ levels, the more I've come to prefer NMN over nicotinamide riboside. It seems to be a lot more effective at actually raising NAD levels.
Having said that, I do still supplement with both since they work through different pathways and I want to cover all my bases.
One thing to note is that there is some concern about the potential for methylation issues here. I take a TMG (trimethylglycine) supplement to compensate. See https://chrismasterjohnphd.com/lite-videos/2018/07/26/careful-niacin-nicotinamide-riboside/ for more info.
Also, if you're taking Elysium, there's more than just NR in there. It may be one of the other ingredients (I think it also has pterostilbene in it?) causing you problems. I generally just go for straight-up NR. I get mine from LEF and I've had no problems with it.
Ive spent years researching anti-aging. It was by accident that I discovered how tightly woven energy production and the immune system actually are. Ill always feel negatively towards NR and NMN. Chromadex, Elysium, and Dr. David Sinclair are, in my opinion, fraudsters or close to it. There needs to be numberous peer reviewed studies published through the N.I.H. before I will consider either product to be more effective than niacinamide alone. Do we even know what the bioavailability of either product is? How long does it work in the body? How long does it need to work before we see a net positive change? What has been changed and for how long?
The people behind these companies have charged out here like theyve discovered the fountain of youth. I vehemently disagree with any such similarities.
From my own research - I've been working as a biochemist for 35 years - I'm aware of both positive and negative responses to oral NAD+. The negative responses seem to be mostly minor and resolve upon discontinuation of the supplement.
I started taking nicotinamide riboside (NR) in Oct. 2016 at my son's suggestion. (These days he's also a biochemist and works in CBD research). I was surprised to discover that after several weeks of consuming NR, I no longer needed as many beta blockers as before to control my atrial fibrillation. I later heard from a leading telomerase researcher that he had also gotten considerable relief of AFib from taking NR. Subsequently I fermented an oral NAD+ product with greatly enhanced bioavailability and have been taking it ever since in lieu of NR. Data from the cardiac clinic at roughly 6 month intervals show that my incidence of AFib decreased from 4.6% of the time to 1.7% to <1% to <0.1%, where it leveled off. A literature search revealed a probable mechanism: AFib is typically associated with mitochondrial dysfunction in cardiomyocytes, which can evidently be ameliorated with intake of NAD+. As a result I was able to decrease my consumption of medication from 7 pills a day (100 mg of beta blockers t.i.d. plus 120 mg of a calcium channel blocker) to just 2 pills (50 mg of beta blockers b.i.d.).
That's the positive news. There were other benefits as well. My NAD+ formula did a remarkable job of reducing painful inflammation in my hands, arms, and shoulders. I could also track the same results with blood tests showing decreasing levels of CRP and ESR (sed rate). Also, my son has been taking the product ever since and claims that for him it's been a more effective antidepressant than SAMe.
The downside of both NR and my formulation is that anything that functions as an antidepressant is potentially anxiogenic and can interfere with sleep. A friend of mine, a molecular biologist at Tufts Medical School, found that he couldn't tolerate a single 250 mg dose of NR because the resulting anxiety drove him up a wall. My girlfriend and several other people can't tolerate either NR or my formula because a single dose keeps them up all night. Fortunately this reaction seems to be relatively rare. I also noticed that any mild insomnia I initially experienced quickly disappeared as my body got used to the product. For several years I've been able to take substantial doses just before bed without adversely affecting sleep.
One other comment about negative effects: a friend of mine was consuming 125 mg sublingual NAD+ b.i.d. until a blood test revealed that she had developed leukopenia (deficiency of white blood cells). Her physician recommended that she stop taking all supplements and the condition spontaneously resolved. It seems likely that excessive intake of NAD+ was the culprit, especially in view of the following paper: https://www.ncbi.nlm.nih.gov/pubmed/31053044.
I have been taking a NAD booster with amazing results. I have been taking it for two years now. I had more dramatic results since taking a double dose. My hair has gotten thicker and even more energy now too, skin improvements as well. I also have my dog on it too and she is going great at 16. I think it has extended her life in my opinion. We both take a telomere supplement as well. I am excited as I am soon taking a senolytics product new to the market. It is being formulated now. They are having issues getting the last ingredient to make it. They said its hard to find someone that makes the ingredient needed in the concentration to be effective. Anyway very excited as I will be giving this to my dog too. Hopefully, she can make it to 18 years or beyond. She is a black lab.